Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Cyclin-Dependent Kinase 5"”.
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Reassessing the role of Cyclin-dependent kinase 5 in tumourigenesis
The discovery of Cyclin-dependent 5 (Cdk5) added a new member to the mammalian Cdks, appearing uncharacteristic of its family members despite strong sequence homology. In contrast to the mitotic Cdks, Cdk5 exerts no apparent role in cell cycle regulation therefore its potential role in cancer is …
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Regulation of synaptic function and plasticity by cyclin-dependent kinase 5
The neuronal serine/threonine kinase cyclin-dependent kinase 5 (Cdk5) is activated by its regulatory subunit, p35, to post-translationally modify substrates through phosphorylation. In this thesis, I provide several lines of evidence that Cdk5 plays a critical role in synaptic function and …
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Regulation of Excitatory Neurotransmission, Synaptic Plasticity, and Learning by Cyclin-Dependent Kinase 5
Cyclin-dependent kinase 5 has been implicated in many physiological and pathological processes in the central nervous system. To better understand Cyclin-dependent kinase 5's roles in the adult brain, we developed and studied several conditional Cyclin-dependent kinase 5 knockout model systems. …
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Design and Synthesis of Benzimidazoles as CDK5 Inhibitors and Progress toward the Total Synthesis of Tubulysin D
… of the Tup fragment was obtained.</p><p> Cyclin dependent kinase 5 (CDK5) is one of the kinases that can hyperphosphorylate tau. Selective inhibition of the CDK5/p25 complex may be a useful component for Alzheimer's disease therapy. Benzimidazole based analogs of the known non-selective …
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Mechanisms and consequences of regulating neurabin and spinophilin's interaction with the tumor suppressor protein p140CAP
… clinical therapeutics available. SRC terminal kinase (SRC) is a tumorigenic protein that is highly expressed in glioblastoma samples. SRC inhibitor kinase 1 (SRCIN1), also known as p140Cap is a negative regulator of SRC. Silencing SRCIN1 results in increased tumor invasion. Our lab has …
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Design and Synthesis of Novel Benzimidazoles and Aminothiazoles as Small Molecule Inhibitors of CDK5/p25
… of novel CDK5/p25 small molecule inhibitors. Cyclin dependent kinase 5 (CDK5) is a proline directed serine/threonine kinase which plays an important role in the pathology of Alzheimer's disease (AD). CDK5/p25 has been implicated in hyperphosphorylation of tau protein which forms …
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Regulation of Phosphorylation of PPARγ by CDK5 in Obesity
… shifting the risk-benefit ratio of these drugs. Cyclin dependent kinase-5 (CDK5) which requires a non-cyclin partner (p35) for activity was proposed to phosphorylate Ser273, while obesity promoted cleavage of p35 to p25 thereby enhancing CDK5 phosphorylation of PPAR? (Choi et al 2010). However …
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The Role of Cdk5 in the Regulation of Dopamine Neurotransmission, Neuronal Excitability, and Reward-Related Behavior
Cyclin-dependent kinase 5 (Cdk5) regulates dopamine neurotransmission and synaptic plasticity and has been implicated as a homeostatic target of chronic psychostimulant exposure. In order to investigate the role of Cdk5 in the modulation of signal transduction pathways that regulate motivation and …
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Molecular modeling and SAR studies of CDK5/p25 selective inhibitors
… senile plaques and neurofibrillary tangles. Cyclin dependent kinase 5 (CDK5) is a proline directed serine/threonine kinase, which expressed primarily in the central nervous system. In the biochemical process the CDK5-natural activator, p35 is cleaved by calpain to a shorter protein p25, which …
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Targeting protein kinases to manage or prevent Alzheimer’s disease
… One such strategy is to modulate protein kinases such as cyclin-dependent kinase 1 (CDK1), cyclin-dependent kinase 5 (CDK5), glycogen synthase kinase-3 (GSK-3α and GSK-3β), and the protein kinase RNA-like endoplasmic reticulum kinase (PERK). AD intervention by reduction of amyloid beta …
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Interplay between collapsin response mediator protein 2 (CRMP2) phosphorylation and sumoylation modulates NaV1.7 trafficking
… of CRMP2 on Nav1.7. Phosphorylation of CRMP2 by cyclin dependent kinase 5 (Cdk5) was necessary for maintaining Nav1.7 surface expression and current density whereas phosphorylation by Fyn kinase reduced CRMP2 SUMOylation and Nav1.7 current density. Binding to Nav1.7 was decreased following (i) …
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Protein Phosphatase Inhibitor-1 and Cdk5: Of Molecules and Memory
Protein phosphatase inhibitor-1 and cyclin-dependent kinase 5 (Cdk5) have been independently implicated in synaptic plasticity, learning, and memory. We began our studies with the identification, confirmation, and characterization of a novel Cdk5-dependent phosphorylation site (Ser6) on …
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The Regulation and Function of Drosophila Acinus
… basal autophagy is based on its starvation-independent activation of the Atg1 kinase.
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The Association Between Traumatic Brain Injury and Alzheimer's Disease: Mouse Models and Potential Mechanisms
… acute Alzheimer-related abnormalities and the independent relationship between amyloid-β and tau in the setting of brain trauma. We next used the 3xTg-AD TBI model to investigate mechanisms responsible for increased tau phosphorylation post brain trauma. We found that TBI resulted in abnormal …
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Regulation des mitochondrialen Zerfalls innerhalb der neuronalen Apoptose
… von Inhibitoren konnte CDK5 als eine Signalkinase identifiziert werden, welche die mitochondrialen Zerteilungsvorgänge während der neuronalen Apoptose reguliert. Als CDK5 Inhibitoren dienten dominant negative Mutanten, anti-CDK5 siRNS und Indolinon A. Durch Beeinflussung der mitochondriale …