Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 150 for “"Cyclin dependent kinase"”.
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Cyclin-Dependent Kinase regulation and function during meiosis
… to occur. Oscillations in the activity of Cyclin- Dependent Kinases (CDKs) drive virtually every event in the mitotic cell cycle, including events such as cell cycle entry, DNA replication, and chromosome segregation. While much is known about the activity of CDKs, the regulation of CDK …
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Leishmania CRK3:CYC6 cyclin-dependent kinase as a drug target
… is coordinated with its cell cycle. There are 11 cyclin dependent kinases (CDKs) and 11 cyclins present in the Leishmania genome reflecting the complexity of cell cycle control in this parasite, perhaps due to the requirement for synchronisation with the life cycle. Leishmania mexicana CRK3, a …
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Reassessing the role of Cyclin-dependent kinase 5 in tumourigenesis
The discovery of Cyclin-dependent 5 (Cdk5) added a new member to the mammalian Cdks, appearing uncharacteristic of its family members despite strong sequence homology. In contrast to the mitotic Cdks, Cdk5 exerts no apparent role in cell cycle regulation therefore its potential role in cancer is …
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Regulation of the cyclin-dependent kinase inhibitor p21 by TBX3
… evidence suggest that TBX3 may repress the cyclin-dependent kinase inhibitor p21WAF1, which has a role in a myriad of processes including cell cycle arrest, senescence, apoptosis, differentiation and DNA replication and repair. The current study therefore aimed to explore this possibility …
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Role of Cyclin-Dependent Kinase Inhibitors in Estrogen Regulation of Adipogenesis
Adipose tissue is responsive to steroid hormones like estrogen. Loss of estrogen receptor a (ERalpha) caused a 100% increase in adipose tissue, indicating the importance of ERalpha signaling. ERalpha knockout mice (alphaERKO) mice have intact ERbeta signaling. Removal of ERbeta/estrogen signaling …
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Regulation of synaptic function and plasticity by cyclin-dependent kinase 5
The neuronal serine/threonine kinase cyclin-dependent kinase 5 (Cdk5) is activated by its regulatory subunit, p35, to post-translationally modify substrates through phosphorylation. In this thesis, I provide several lines of evidence that Cdk5 plays a critical role in synaptic function and …
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Regulation of Excitatory Neurotransmission, Synaptic Plasticity, and Learning by Cyclin-Dependent Kinase 5
Cyclin-dependent kinase 5 has been implicated in many physiological and pathological processes in the central nervous system. To better understand Cyclin-dependent kinase 5's roles in the adult brain, we developed and studied several conditional Cyclin-dependent kinase 5 knockout model systems. …
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Regulation of Ciz1 by Cyclin A-Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation
… process, regulated by the activities of cyclin dependent kinases. Phosphorylation of target proteins regulates key transitions in the cell cycle contributing to accurate DNA replication and cell division. Here we evaluate the regulation of the protein Ciz1 by cyclin A-CDK2. Ciz1 promotes …
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Targeting transcription-regulating cyclin dependent kinase 12 for the treatment of breast cancer
Cyclin-dependent Kinase 12 (CDK12) with its binding partner Cyclin K regulates transcription through phosphorylation of RNA Polymerase II (RNA Pol II) at serine 2. Previous work showed that inhibition of CDK12 leads to decreased expression of DNA damage response (DDR) genes and sensitizes cancer …
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Synthesis of the small peptide analogues of cyclin dependent kinase (CDK4) for cancer treatment
Cyclin-dependent kinases (CDKs) are a group of enzymes that are involved in cell cycle progression regulation. The CDKs activate host proteins through phosphorylation on serine or threonine using adenosine triphosphate as a phosphate donor. Especially, cyclindependent kinase 4 (CDK4) has attracted …
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Functional characterization of the cyclin-dependent kinase inhibitor p21 by gene targeting in the mouse
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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SCF SKP2B - AND KPC1-DEPENDENT DEGRADATION OF CYCLIN-DEPENDENT KINASE INHIBITOR KRP1 AND CELL CYCLE REGULATION IN ARABIDOPSIS THALIANA
In animals and fungi, cyclin-dependent kinase inhibitors play a key role in cell cycle regulation by inhibiting the activities of cyclin-dependent kinase/cyclin complexes. However, little is known about the role of this group of proteins in plant cell cycle regulation. To gain insight into the …
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Multiple Levels of Regulation of Cyclin-dependent Kinase Inhibitor 1A (p21/WAF-1) by the <i>DDX5 </i>Gene
… helicases, exhibits both ATPase and RNA helicase dependent/independent activities. To date the p68 protein has been implicated in most parts of RNA metabolism including ribosome biogenesis, transcription, RNA decay, miRNA processing and pre-mRNA processing. Alterations in both expression and …
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Impact of Cyclin-Dependent Kinase 4 and 6 Inhibitors on Chemotherapy Utilization and Overall Survival in Women with HR+/HER2– Metastatic Breast Cancer in the United States
… lines. In this study, we explored the impact of cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor therapy class, introduced in 2015, on early chemotherapy utilization in an older population of patients with HR+/HER2– MBC in the United States (US). Methods: Using an interrupted time series …
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The role of anchorage in cell cycle control
… known as anoikis, due to activation of anchorage-dependent checkpoint mechanisms. Transformed cells alleviate these checkpoints, via activation of oncogenes and/or inactivation of tumour suppressors. In contrast, detachment of normal cells halts cell-cycle progression in G1, because of …
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P27 Expression in Endothelin-1 Stimulated Mitogenesis
… mitogenic activity is mediated through the cyclin dependent kinase inhibitor p27. BCEC were isolated from bovine eyes and grown in DMEM-10% serum in a 5% C02, 37° C incubator. Confluent cultures of BCEC were incubated for 24 hours with lOOnM Endothelin-1, luM BQ123 and BQ123 +100nM …
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Regulation of the Anaphase-Promoting Complex Examined at the Single Cell Level
… cycle transitions are driven by oscillations of cyclin-cyclin dependent kinase (CDK) activity and associated cyclin degradation, mediated by ubiquitylation by the anaphase-promoting complex (APC). In this work, I analyzed the regulation of the APC by its activator Cdh1 in budding yeast in single …
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The role of p27 phosphorylation in mediating atRA sensitivity of ovarian carcinoma cells
… including the retinoblastoma family of proteins, cyclin dependent kinases (Cdks), and cyclin dependent kinase inhibitors. P27, a cyclin dependent kinase inhibitor regulating G1 checkpoint has been shown to have elevated levels in response to atRA treatment. In these studies we investigated the …
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Mechanisms of Transcriptional Control by the Mediator Complex Subunit Cdk8
… bridge between RNAPII and transcription factors. Cyclin-dependent kinase 8 (Cdk8) is the only enzymatic subunit in the entire Mediator complex, and it resides in a dissociable module with CycC, Med12, and Med13. Cdk8 regulates transcription by phosphorylating transcription factors in response to …
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