Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Cyclin T1"”.
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Targeting Cyclin T1 in Cancer
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Recombinant Expression, Purification, and Characterization of an HIV-1 Tat-Human Cyclin T1 Chimera
… of HIV-1 Tat with the host protein human Cyclin T1. Interaction with hCycT1 remodels Tat protein contributing a single cysteine residue that is critical to the formation of the second of two zinc fingers (Zn2). Here we suggest that it is the presence of this critical cysteine residue and …
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Myc and Cyclin T1 co-expression as a therapeutic strategy for cardiac repair following myocardial infarction
… of ischaemic damage. Overexpression of Ccnt1 creates a permissive molecular environment for Myc-driven cell cycle reactivation in organs with limited regenerative capacity, such as the adult mammalian heart. The overarching goal of this study is to elucidate whether the co-expression of Myc …
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In vitro-Selektion am lentiviralen Transaktivator-Protein aus HIV-1
… mit dem zellulären Kofaktor Cyclin T1 konnte die Affinität und Spezifität der Bindung von HIV-Tat an HIV-TAR-RNA gesteigert werden. Somit konnte zum ersten Mal der in vitro und in vivo dokumentierte Einfluss eines Kofaktors in einem Phagen-Display-System reproduziert werden. …
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Strukturelle Untersuchung des Antiterminationskomplexes von EIAV
… des Proteins bei der Wechselwirkung mit TAR-RNA, Cyclin T1 und dem Inhibitor TF53 auf der Basis einzelner Aminosäuren direkt in einem 15N-1H-HSQC-Spektrum beobachtet werden. Es konnte gezeigt werden, dass das EIAV-Tat-Protein ohne die Beteiligung weiterer Bindungspartner an die TAR-RNA bindet. Bei …
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HETEROGENEITY OF LATENCY ESTABLISHMENT IN DIFFERENT HUMAN CD4+ T CELL SUBSETS STIMULATED WITH INTERLEUKIN-15
… elongation factor b (P-TEFb) components Cyclin T1 and phospho/Cyclin-dependent kinase 9 (P/CDK9). When we analyzed the cellular distribution of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcription factor, which is important for HIV expression, we …
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Investigating coordination between stress-induced translational and transcriptional attenuation
… that SITA is inhibited by overexpression of the cyclin in the positive transcription elongation factor b (P-TEFb) complex, cyclin T1 (CCNT1), during acute heat shock (HS) and oxidative stress in cellulo. In identical conditions, CCNT1 overexpression has been shown to regulate the rate of ISR …