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Showing 1 to 3 of 3 for “"Cyclin E2"”.
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Genregulation des Zellzyklusmediators Cyclin E2 in humanen und murinen Hepatomzellen
Cyclins E1 and E2 are required for transition of quiescent cells into cell cycle progression. Recent data show that both E-Cyclins have a regulatory effect on each other. Especially the overexpression of Cyclin E2 in liver leads to inhibition of Cyclin E1 and reduces cell proliferation of …
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Cell cycle regulation in the liver : differential functions of E-type cyclins E1 and E2 for G1/S-phase transition and endoreplication in mice
E-type cyclins are important regulators for driving quiescent cells into the cell cycle. The aim of the present study was to investigate the relevance of cyclin E1 and E2 for directing quiescent hepatic cells into the cell cycle in vivo. In the partial hepatectomy (PH) model it was shown that …
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Combined Inhibition of Ddr1 and Cdk4/6 Induces Synergistic Effects In Er-Positive, Her2-Negative Breast Cancer With Pik3Ca/Akt1 Mutations
… metastatic breast cancer are often treated with cyclin-dependent kinase (CDK4/6) inhibitors such as palbociclib in combination with endocrine therapy. Although this is a very effective regimen, disease progression ultimately occurs in most patients. Further, the modulators of palbociclib …