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Showing 1 to 20 of 429 for “"Cyclin"”.

  1. Functional Analysis Of A Highly Conserved Cyclin, Cyclin Y, In Drosophila Melanogaster

    Gerges, Nermin2015

    <p>Cyclin Y is a highly conserved member of the Cyclin superfamily of proteins. In Drosophila the Cyclin Y gene (CycY) is required for progression through several stages of development but the specific pathways that Cyclin Y belongs to and that account for its requirement are not known. Studies in …

    wayne-thes Repository record

  2. Determination Of The Essential Functions Of A Conserved Cyclin, Cyclin Y, In Drosophila

    Liu, Dongmei2010

    … encodes a member of a highly conserved family of cyclins, the Y type cyclins, which have not been functionally characterized in any organism. Here I report the generation and phenotypic characterization of a null mutant of <i>CG14939</i>, which we rename <i>Cyclin Y</i> (<i>CycY</i>). I show that …

    wayne-thes Repository record

  3. Regulation of Ciz1 by Cyclin A-Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation

    Baxter, Diana, Copeland, NikkiLancaster University2016

    … process, regulated by the activities of cyclin dependent kinases. Phosphorylation of target proteins regulates key transitions in the cell cycle contributing to accurate DNA replication and cell division. Here we evaluate the regulation of the protein Ciz1 by cyclin A-CDK2. Ciz1 promotes …

    lancaster Repository record

  4. Targeting Cyclin T1 in Cancer

    Blenkarn, LauraUniversity of Cambridge2025

    [Restricted]

    cambridge Repository record

  5. Peak Mitotic Cyclin Permits Mitotic Exit

    Drapkin, Benjamin

    … mitosis, and cytokinesis are all regulated by Cyclin-dependent kinase (Cdk). Cyclin/Cdk complexes promote replication origin firing and mitotic entry, and conversely, inhibit pre-replication origin loading and exit from mitosis. Cyclin synthesis and degradation, Cdk phosphorylation and Cdk …

    rockefeller Repository record

  6. Meiotic regulation of cyclin-dependent kinases

    Miller, Matthew P., Ph. D. (Matthew Paul). Massachusetts Institute of TechnologyMassachusetts Institute of Technology2013

    During meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain together. Determining how this unusual chromosome segregation behavior is …

    mit Repository record

  7. Analysis of cyclin dependent kinases in Leishmania

    Gomes, Felipe CampeloUniversity of Glasgow2007

    … this study aimed to further explore the role of cyclin dependent kinases and cyclins in the protozoan parasite Leishmania major. Cdks in kinetoplastids, CRKs, are the key regulators that allow cells to progress through different cell cycle phases and promote parasite proliferation during …

    glasgow Repository record

  8. Cyclin-dependent kinase inhibitors of Arabidopsis thaliana

    Verkest, AurineGhent University. Faculty of Sciences2006

    ghent Repository record

  9. Cyclin-Dependent Kinase regulation and function during meiosis

    Carlile, Thomas M. (Thomas Marshal), JrMassachusetts Institute of Technology2010

    … to occur. Oscillations in the activity of Cyclin- Dependent Kinases (CDKs) drive virtually every event in the mitotic cell cycle, including events such as cell cycle entry, DNA replication, and chromosome segregation. While much is known about the activity of CDKs, the regulation of CDK …

    mit Repository record

  10. Cell Cycle Control by Cyclin-CDKS in Chlamydomonas Reinhardtii

    Atkins, Kenneth C

    … and fungi in which the activities of various cyclin-dependent kinases (CDKs) and the anaphase promoting complex (APC) drive the events of the cell cycle at the appropriate time and in the appropriate order. While this model has been extremely useful for understanding cell division in these …

    rockefeller Repository record

  11. Cyclin-dependent kinases and nuclear functions in Arabidopsis thaliana

    Alexiou, Konstantinos GUniversity of East Anglia2011

    east-anglia Repository record

  12. Regulation of Cyclin G2 Degradation in Human Ovarian Cancer Cells

    Khazai, Shahin2017

    … is governed by temporal expression of canonical cyclin molecules, which then bind to and activate CDKs. Cyclin G2, an unconventional cyclin, negatively regulates cell cycle and its levels are lowered in various types of cancer. Our lab has previously reported that cyclin G2 is an unstable …

    york Repository record

  13. Leishmania CRK3:CYC6 cyclin-dependent kinase as a drug target

    Walker, Roderick G.University of Glasgow2008

    … is coordinated with its cell cycle. There are 11 cyclin dependent kinases (CDKs) and 11 cyclins present in the Leishmania genome reflecting the complexity of cell cycle control in this parasite, perhaps due to the requirement for synchronisation with the life cycle. Leishmania mexicana CRK3, a …

    glasgow Repository record

  14. Reassessing the role of Cyclin-dependent kinase 5 in tumourigenesis

    Grant, Nicola JoanUniversity of Dundee2014

    The discovery of Cyclin-dependent 5 (Cdk5) added a new member to the mammalian Cdks, appearing uncharacteristic of its family members despite strong sequence homology. In contrast to the mitotic Cdks, Cdk5 exerts no apparent role in cell cycle regulation therefore its potential role in cancer is …

    dundee Repository record

  15. Regulation of the cyclin-dependent kinase inhibitor p21 by TBX3

    Hare, ShannaghDepartment of Human Biology2013

    … evidence suggest that TBX3 may repress the cyclin-dependent kinase inhibitor p21WAF1, which has a role in a myriad of processes including cell cycle arrest, senescence, apoptosis, differentiation and DNA replication and repair. The current study therefore aimed to explore this possibility …

    cape-town Repository record

  16. Targeting Cyclin Dependent Kinases 4/6 Activity in Pancreatic Ductal Adenocarcinoma

    Franco, Jorge2018

    Pages vi-xiii are incorrectly numbered as pages v-xii.

    utswmed Repository record

  17. Cytoplasmic Cyclin E Mediates Resistance to Aromatase Inhibitors In Breast Cancer

    Doostan, Iman2018

    … of such resistance is not completely understood. Cyclin E is deregulated in breast cancer through generation of low molecular weight isoforms that renders patients to a poor survival. Herein, we show that HR+ patients with LMW-E expressing tumors show diminished early response to neo-adjuvant AIs …

    uthsc Repository record

  18. Role of Cyclin-Dependent Kinase Inhibitors in Estrogen Regulation of Adipogenesis

    Naaz, AfiaUniversity of Illinois at Urbana-Champaign2015

    Adipose tissue is responsive to steroid hormones like estrogen. Loss of estrogen receptor a (ERalpha) caused a 100% increase in adipose tissue, indicating the importance of ERalpha signaling. ERalpha knockout mice (alphaERKO) mice have intact ERbeta signaling. Removal of ERbeta/estrogen signaling …

    uiuc Repository record

  19. Regulation of synaptic function and plasticity by cyclin-dependent kinase 5

    Su, Susan C. (Susan Chih-Chieh)Massachusetts Institute of Technology2013

    The neuronal serine/threonine kinase cyclin-dependent kinase 5 (Cdk5) is activated by its regulatory subunit, p35, to post-translationally modify substrates through phosphorylation. In this thesis, I provide several lines of evidence that Cdk5 plays a critical role in synaptic function and …

    mit Repository record

  20. The Role and Regulation of Cyclin G2 in Human Ovarian Cancer Cells

    Bernaudo, Stephanie2015

    … Cell division is under direct regulation of the cyclin family. Typical cyclins will accumulate periodically to activate cyclin-dependent kinases (CDKs) leading to the unidirectional flow of the cell cycle, whereas the unconventional G-type cyclins (cyclin G1, G2, and I) act to oppose cell cycle …

    york Repository record

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