Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 444 for “"Cyclin"”.
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Charakterisierung von Cyclin L2 : ein neuer Vertreter der Cyclin-Familie
… the protein function of DYRK1A remains unclear. Cyclin L2, a recently identified substrates of DYRK1A, combines the unique combination of cyclin domain and arginine-serine-rich domain (rs-domain). These rs-domains comprise a hallmark for splicing factors. The intention of this thesis was to …
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Functional Analysis Of A Highly Conserved Cyclin, Cyclin Y, In Drosophila Melanogaster
<p>Cyclin Y is a highly conserved member of the Cyclin superfamily of proteins. In Drosophila the Cyclin Y gene (CycY) is required for progression through several stages of development but the specific pathways that Cyclin Y belongs to and that account for its requirement are not known. Studies in …
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Determination Of The Essential Functions Of A Conserved Cyclin, Cyclin Y, In Drosophila
… encodes a member of a highly conserved family of cyclins, the Y type cyclins, which have not been functionally characterized in any organism. Here I report the generation and phenotypic characterization of a null mutant of <i>CG14939</i>, which we rename <i>Cyclin Y</i> (<i>CycY</i>). I show that …
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Regulation of Ciz1 by Cyclin A-Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation
… process, regulated by the activities of cyclin dependent kinases. Phosphorylation of target proteins regulates key transitions in the cell cycle contributing to accurate DNA replication and cell division. Here we evaluate the regulation of the protein Ciz1 by cyclin A-CDK2. Ciz1 promotes …
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Targeting Cyclin T1 in Cancer
[Restricted]
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Peak Mitotic Cyclin Permits Mitotic Exit
… mitosis, and cytokinesis are all regulated by Cyclin-dependent kinase (Cdk). Cyclin/Cdk complexes promote replication origin firing and mitotic entry, and conversely, inhibit pre-replication origin loading and exit from mitosis. Cyclin synthesis and degradation, Cdk phosphorylation and Cdk …
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Meiotic regulation of cyclin-dependent kinases
During meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain together. Determining how this unusual chromosome segregation behavior is …
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Analysis of cyclin dependent kinases in Leishmania
… this study aimed to further explore the role of cyclin dependent kinases and cyclins in the protozoan parasite Leishmania major. Cdks in kinetoplastids, CRKs, are the key regulators that allow cells to progress through different cell cycle phases and promote parasite proliferation during …
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Cyclin-Dependent Kinase regulation and function during meiosis
… to occur. Oscillations in the activity of Cyclin- Dependent Kinases (CDKs) drive virtually every event in the mitotic cell cycle, including events such as cell cycle entry, DNA replication, and chromosome segregation. While much is known about the activity of CDKs, the regulation of CDK …
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Cell Cycle Control by Cyclin-CDKS in Chlamydomonas Reinhardtii
… and fungi in which the activities of various cyclin-dependent kinases (CDKs) and the anaphase promoting complex (APC) drive the events of the cell cycle at the appropriate time and in the appropriate order. While this model has been extremely useful for understanding cell division in these …
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Genregulation des Zellzyklusmediators Cyclin E2 in humanen und murinen Hepatomzellen
Cyclins E1 and E2 are required for transition of quiescent cells into cell cycle progression. Recent data show that both E-Cyclins have a regulatory effect on each other. Especially the overexpression of Cyclin E2 in liver leads to inhibition of Cyclin E1 and reduces cell proliferation of …
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Regulation of Cyclin G2 Degradation in Human Ovarian Cancer Cells
… is governed by temporal expression of canonical cyclin molecules, which then bind to and activate CDKs. Cyclin G2, an unconventional cyclin, negatively regulates cell cycle and its levels are lowered in various types of cancer. Our lab has previously reported that cyclin G2 is an unstable …
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Leishmania CRK3:CYC6 cyclin-dependent kinase as a drug target
… is coordinated with its cell cycle. There are 11 cyclin dependent kinases (CDKs) and 11 cyclins present in the Leishmania genome reflecting the complexity of cell cycle control in this parasite, perhaps due to the requirement for synchronisation with the life cycle. Leishmania mexicana CRK3, a …
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Reassessing the role of Cyclin-dependent kinase 5 in tumourigenesis
The discovery of Cyclin-dependent 5 (Cdk5) added a new member to the mammalian Cdks, appearing uncharacteristic of its family members despite strong sequence homology. In contrast to the mitotic Cdks, Cdk5 exerts no apparent role in cell cycle regulation therefore its potential role in cancer is …
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Regulation of the cyclin-dependent kinase inhibitor p21 by TBX3
… evidence suggest that TBX3 may repress the cyclin-dependent kinase inhibitor p21WAF1, which has a role in a myriad of processes including cell cycle arrest, senescence, apoptosis, differentiation and DNA replication and repair. The current study therefore aimed to explore this possibility …
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Targeting Cyclin Dependent Kinases 4/6 Activity in Pancreatic Ductal Adenocarcinoma
Pages vi-xiii are incorrectly numbered as pages v-xii.
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