Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Cyclic-di-nucleotide"”.
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Regulatory Mechanisms in Innate Immunity
… in IRF5 have been closely related to autoimmune diseases. However, the mechanism by which IRF5 is activated is not well understood. In the first part of this dissertation, I presented evidence that the kinase IKK2 phosphorylates IRF5 on Serine 445, leading to its dimerization and nuclear …
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Toward the Rational Design of Better Antivirals: The Development of cGAMP as an HIV-1 Anti-Retroviral and the Genetic Surveillance of WNV Evolution
… hurdle viruses must overcome to cause severe disease in humans. Understanding the consequences of viral evolution can give insights to mechanisms of viral pathogenesis as well as the development of novel therapeutics. Here I studied two clinically important viruses: Human Immunodeficiency …
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Synthesis of Non-Natural Cyclic Di-Nucleotides for the Investigation of Bacterial Signaling Pathways
… the ability to communicate, albeit in more discreet, yet no less complex ways. Bacteria rely on an incredibly diverse signaling system of triggers and responses in order to survive and to thrive. While we perceive language with our eyes and ears, bacteria employ a system of small molecules …