Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Cyclic nucleotide phosphodiesterase"”.
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Studies on the Mechanism of Action of Calmodulin
… interactions of CaM with Ca('2+)+CaM sensitive cyclic nucleotide phosphodiesterase (PDE) and with troponin I. Because CaM has been found to behave in a similar manner in most, if not all, of the systems in which it is a participant, information gathered with these systems may be of general …
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Going With The Flow: Selective phosphodiesterase 4D7 (PDE4D7) regulation of vascular endothelial cell responses to fluid shear stress
… exchange protein activated by cAMP (EPAC1) and cyclic nucleotide phosphodiesterase 4D (PDE4D) populate a multi-protein signalling complex along with VE- cadherin. These proteins function together to regulate VEC barrier function, cell morphology and gene expression of in response to FSS. Now, we …
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Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells
… might limit these problems. Since the cyclic nucleotide phosphodiesterase, PDE1C, a dual cAMP/cGMP hydrolyzing PDE, is exclusively expressed by synthetic VSMCs and regulates their synthetic, migratory and proliferative actions, it may represent a valid synthetic VSMC specific …
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Purification of Calmodulin and Quantification of Its Levels in Mammary Tissue and Isolated Cells During Pregnancy and Lactation (Acini, Secretory, Myoepithelial)
… stimulation of the activity of bovine brain cyclic nucleotide phosphodiesterase (PDE) in a calcium dependent manner. This report details a method for the assay of biologically active calmodulin from lactating mammary tissue based on stimulation of PDE. The present study also reports the …
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Investigating the Role of Phosphodiesterase 1C in Vascular Smooth Muscle Cell Migration and Invasion
… and others have identified the critical role of cyclic nucleotide phosphodiesterase 1C (PDE1C) in HASMC migration, proliferation, and extracellular matrix adhesion. Here, we directly tested the hypothesis that cAMP signaling, and specifically PDE1C, influences the ability of activated/synthetic …
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STUDIES ON A CALCIUM-DEPENDENT ACTIVATOR PROTEIN, STRUCTURALLY AND FUNCTIONALLY HOMOLOGOUS TO CALMODULIN, FROM THE WATER MOLD ACHLYA AMBISEXUALIS RAPER.
A Ca('2+)-dependent activator of bovine cyclic nucleotide phosphodiesterase (PDE) from the oomycetous water mold Achlya ambisexualis was purified and characterized; it is an electrophoretically homogeneous protein (pI 4.3), migrates slightly faster than bovine calmodulin (CaM) and shows a …
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Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs
… is scarce with regard to the regulation of cyclic nucleotide phosphodiesterase 3B (PDE3B) in pancreatic β-cells. We show that PDE3B is activated in response to glucose, insulin and forskolin, which is coupled to a decrease, no apparent change or an increase in total phosphorylation of the …
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The Arf GTPase exchange factor Sec7p interaction network:
… Arf-GEF Sec7p: the lipid kinase Pik1p and the cyclic nucleotide phosphodiesterase Cpd1p. In addition, our studies on the function of Sec7p revealed additional feature of this protein and it’s relationship to the other yeast Golgi Arf-GEFs. Arf proteins and their regulators play an important …