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Showing 1 to 11 of 11 for “"Cyclic amines"”.
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New chiral molybdenum metathesis catalysts : application to the enantioselective preparation of cyclic amines
… desymmetrization of unsaturated prochiral amines to afford tetrahydropyridines (2.68a-e). The selectivity of this transformation was sensitive to the olefin substitution pattern of the prochiral amine. However, this novel method was also applicable for the formation seven-(2.84), and …
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Palladium-Catalysed Functionalisation of Csp3–H Bonds Directed by Aliphatic Amines
… on medicinally-relevant aliphatic amines are valuable in the diversification of molecules designed as pharmaceutical agents. This thesis describes two Csp3–H functionalisation reactions, using native amines (secondary and tertiary) to direct C–H activation. Chapter 2 describes a …
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1,3-Aminoalkohole als Bausteine in der asymmetrischen Synthese von Azetidinen, Azetidincarbonsäuren und Piperidin-3-olen
Four-membered cyclic amines – the azetidines – are an original class of compounds with limited occurrence in nature. Nevertheless enantiopure azetidines and in particular derivatives of the azetidine-2-carboxylic acid are used in medicine, crop protection and asymmetric catalysis. Despite these …
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Palladium-mediated C–H Functionalization of Aliphatic Amines via High Valent Palladium(IV) Intermediates
… C–H functionalization of unprotected aliphatic amines, in which the amine nitrogen coordinates to the Pd centre to promote cyclometalation to the key palladacycle intermediate. Specifically, research focused on the design and optimization of novel oxidants that would provide mild and general …
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The development of directing group enabled hydroamination strategies to access to 1,2-, 1,3-, and 1,4- diamines with high levels of regio-, chemo-, and stereoselectivity
… reaction of olefins, as olefins and amines are both readily accessible. This reaction has the potential to be entirely atom-economical, as well as modular. Another advantage, and concomitant challenge, that comes with this strategy, is the ability to form multiple isomers: there are …
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Synthesis and Characterization of Poly(2-Ethyl-2-Oxazoline) Functional Prepolymers and Block Copolymers
… all cases, termination reactions with aliphatic cyclic amines were quantitative. Mono- and diamine functional PEtOx oligomers with controlled molecular weight and excellent end-group functionality may be used as prepolymers for incorporation into multiblock and graft copolymer and crosslinked …
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Development of Deactivation-Resistant Catalysts for Pd-Catalyzed C–N Cross-Coupling Reactions
… reactions between a variety of primary amines and aryl halides, was developed; in many cases, these reactions can be carried out at room temperature. The reaction development was guided by the idea that the productivity of catalysts employing BrettPhos-like ligands is limited by their …