Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Cyano Group"”.
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Synthesis of nitrogen heterocycles via the intramolecular [4+2] cycloaddition of iminoacetonitriles
… with a high preference for an exo-orientated cyano group due to the a-amino nitrile anomeric effect. The substrates for these [4+2] cycloadditions are prepared from readily available alcohols via a Mitsunobu reaction with the previously unknown N-cyanomethyltriflamide (HN(Tf)CH₂CN) followed by …
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Regio- and Stereo- selective Methods for the Borylation of Substituted Alkynes
… due to the electron-withdrawing nature of the cyano group on the adjacent alkyne. In this dissertation, we developed a phosphine-catalyzed regio- and stereo-selective hydroboration of propiolonitriles to generate novel β-borylacrylonitriles in up to 89% yield and 97:3 (E)-selectivity. These …
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Surface -enhanced Raman spectroscopic studies of organonitriles on copper colloids
… metal assisted borohydride reduction of the cyano group to an amino group. SER spectra of the reduction products of the organonitriles in the presence of copper colloids are identical within experimental error. The nu(C≡N) signal was observed when a gold colloid was prepared by …
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The Development of 2,3-Diarylindenes as Integrated Fluorescent Estrogens
… to the 2-aryl ring. In the p-position, the nitro group produced a quasi-planar intramolecular charge transfer state, with emission from 490 nm in heptane to 672 nm in acetonitrile. In the m-position, a nitro group produces a twisted intramolecular charge transfer (TICT) state with emission up to …
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Synthesis of Biologically Relevant Sphingolipid Analogues
… such that future introduction of different aryl groups is straightforward. Throughout the synthetic coarse, we gained access to a number of structural analogues, which provided more insight into the structure-activity relationship of this class of compounds. Biological evaluation, both in vitro …
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Further Exploring the Structure Activity Relationship (SAR) of MMV008138 and MMV1803522
… compounds that have been studied in the Carlier Group. My research focused on the structural variation of each of these compounds, in the hope that greater potency could be realized. Chapter 2 describes my work on (1S,3R)-MMV008138, which inhibits the enzyme PfIspD in the methylerythritol …
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A study of the synthesis and reactions of new polynuclear aromatic acids and related compounds
… the experimental observations. The ketone, 2-(3-cyano-l-naphthylmethyl)benzophenone was prepared by the reaction of the corresponding chloro ketone with cuprous cyanide in N-methylpyrrolidone. 6-Cyano-7-phenylbenz[a]- anthracene was also produced in small quantity in this reaction as a …
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SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOACTIVE MOLECULES LINKED TO PHOTOREMOVABLE PROTECTING GROUPS FOR SPATIO-TEMPORAL CONTROL OF THEIR ACTIVITY THROUGH PHOTOACTIVATION
… therapy (PDT), and photoremovable protecting groups (PPGs) play important roles in pharmaceutical research. The focus of this doctoral research lies on PPGs: these are chromophores covalently linked to approved drugs or bioactive molecules at functional groups essential for their activity. The …