Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Cxcr1"”.
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BIOLOGICAL AND TRANSDUCTIONAL EFFECTS OF ALLOSTERIC ANTAGONISTS ON THE ACTIVITY OF CHEMOATTRACTANT RECEPTORS
… expressed on the surface of neutrophils, CXCR1 and CXCR2.It is thought that targeting both receptors may be necessary for optimal inhibition of PMN influx in several inflammation disorders such as post-ischemia reperfusion injury, pulmonary fibrosis, sepsis, psoriasis among other. DF 2156A …
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Investigating the Role of Chemokines in Neutrophil Recruitment and Resolution During Inflammation
… trafficking of two chemokine receptors, Cxcr1 and Cxcr2, which were previously shown to mediate clustering and dispersal of neutrophils, respectively. I demonstrate that Cxcr1 recognises Cxcl8a and is rapidly internalised, whereas Cxcr2 recognises Cxcl8b and traffics in a manner …
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The role of chemokine receptor trafficking in regulating neutrophil migration to inflammatory sites
… signals through two G-protein coupled receptors, Cxcr1 and Cxcr2. Through new in vivo biosensors, I show that Cxcr1 and Cxcr2 exhibit differential trafficking in response to endogenous gradients. Cxcr1 is extensively internalised whilst Cxcr2 is sustained on the cell membrane. Live-imaging of …
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The structural basis of chemokine binding affinity and receptor selectivity: Role of receptor N-terminal domain
… MGSA monomers and dimers with their receptors CXCR1 and CXCR2. CXCR1 is specific and binds IL-8 alone with high affinity, whereas CXCR2 is promiscuous and binds both ligands with high affinity. The receptor structures are not known, and also due to the intrinsic difficulties of working with …
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Behavioral alterations in rat offspring following maternal immune activation and CXC chemokine receptor antagonism
… a chemokine receptor antagonist that binds CXCR1 and CXCR2 with high affinity. PolyI:C treatment significantly increased maternal levels of the chemokine CXCL1, the rodent analogue of IL-8 that binds CXCR1 and CXCR2. The offspring of polyI:C-treated dams showed impaired associative …
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Inflammation and neutrophil recruitment in ageing subjects and patients with chronic obstructive pulmonary disease
… migrating, and had reduced surface expression of CXCR1 and CXCR2. Inhibitory studies suggested that CXCR2 was the predominant receptor in migration to biological samples. Treating COPD cells with a PI3 Kinase inhibitor differentially altered their migration, reducing speed but increasing accuracy, …
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Increased Inflammatory Gene Expression in Masseter Muscle of an Orthognathic Surgery Subject with Obstructive Sleep Apnea
… and chemokine genes CCL2, CCL3, CCL3L3, CCL4 and CXCR1 were +2.0 to +12.1 fold greater (p < 0.05). Likewise, TNF expression differed significantly in the muscle of the OSA subject (+2.2 fold greater; p < 0.001). By quantitative RT-PCR, TNF expression was significantly greater in malocclusion …
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Diverse roles of cyclooxygenase in the central nervous system and the periphery
… chemoattractant molecules, CCL2, CCR1, CCR5 and CXCR1, and CD11b induction. On immunohistochemical analysis, CFA increased infiltration of CD11b-positive cells in the synovium which was co-localized with COX-2. After three days, neutrophils, myeloperoxidase (MPO)-positive cells filled the …
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Modelling fitness and stability of G protein-coupled receptor variants
… However, I did not observe a similar effect for CXCR1. I concluded that rare variants which reduce CXCR2 function are likely to be associated with neutrophil count in humans. Overall, I have shown that single-amino acid variants in GPCRs can be characterised effectively using interpretable …