Global ETD Search
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Showing 1 to 6 of 6 for “"Cx40"”.
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Cardiovascular Characterization of Cx40/Panx1 Single and Double Knockout Mice
… this possibility we crossed Panx1 null mice with Cx40 knockout mice and characterized the first global connexin/pannexin double knockout mouse. Intriguingly, the combined ablation of both Cx40 and Panx1 caused decreased prenatal and newborn survival, but did not affect the fertility or lifespan of …
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Mutations in Connexin43 and Connexin40 Associated with Human Atrial Fibrillation; Physiology and Mechanism
… cardiac connexin genes, GJA1 (Cx43) and GJA5 (Cx40), have been identified by our group in a cohort of patients with lone AF. To characterize trafficking of a novel somatic frameshift Cx43 mutant and three novel Cx40 mutants, fluorescently tagged connexins were visualized in HeLa cells using …
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Function Study of Atrial Fibrillation-Linked Connexin Mutants and Heterotypic Docking Compatibility of Cardiac Connexins
… potentials in the heart. Many autosomal dominant Cx40 mutations have been linked to atrial fibrillation (AF) and have showed GJ impairments. However, others such as L221I and V85I showed apparently no GJ impairments. Cells expressing L221I or V85I alone showed increased propidium iodide uptake, …
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The Ultrastructural and Abnormal Calcium Handling in Pulmonary Vein Sleeve Cells, Atrial and Ventricular Myocytes During Ageing
… atrial and ventricular myocytes, express RyR2, Cx40, and Cx43. Whilst RyR2 and Cx43 expressions did not change with age, Cx40 expression was found to deteriorate during ageing. Additionally, EM studies showed significant alterations in mitochondria which increased in size and numbers during …
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FATE OF Cx43 IN CARDIAC AND EPIDERMAL TISSUES HARBOURING A DISEASE-LINKED Cx43 MUTANT
… protein. Compensation via the up-regulation of Cx40 or Cx45 was not observed in the heart and there was a concurrent 75% down-regulation of Cx26 in the skin. Immunohistochemistry revealed a trafficking defect, with a population of Cx43 retained in the Golgi apparatus. Despite the decrease in …
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Single channel studies on the modulation of connexin hemichannels by Cx43 targeting peptides and cytoplasmic Ca2+ in the context of heart disease
… hemichannels without blocking gap junctions or Cx40/pannexin-1 hemichannels. As exemplified by surface plasmon resonance, the selective effect on hemichannels is due to direct binding of Gap19 to the end of CT thereby preventing intramolecular CT-CL interactions which are essential for Cx43 …