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Showing 1 to 3 of 3 for “"CwlD"”.
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Analysis of the Roles of the cwlD Operon Products during Sporulation in Bacillus subtilis
CwlD has sequence similarities to N-acetyl muramoyl-L-alanine amidases, a class of enzymes known to cleave the bond between the peptide side chain and the N-acetyl muramic acid residue in cortex peptidoglycan formation during sporulation. A major difference between vegetative peptidoglycan and …
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Investigating the Roles of CwlD and GerS in <i>Clostridioides difficile</i> Spore Cortex Modification
… and germination. This work examines the enzyme CwlD, which facilitates the transformation of N-acetylmuramic acid (NAM) into muramic-δlactam (MAL)—a change crucial for adequate cortex production and germination. The lipoprotein GerS is essential for CwlD function in C. difficile; however, no …
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Investigating the enzyme activity of a <i>Clostridioides difficile</i> amidase complex
… the endospore cortex is forming, the enzymes CwlD and PdaA convert N-acetylmuramic acid (NAM) into muramic--lactam (MAL). MAL serves as a recognition element for germination-specific lytic enzymes that degrade cortex peptidoglycan layers during germination. Without the MAL residues the …