Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Cutaneous Squamous Cell Carcinoma"”.
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Genomic Drivers of Cutaneous Squamous Cell Carcinoma Development
… estimated overall economic impact of $2 billion. Cutaneous Squamous Cell Carcinoma (cuSCC) comprises 15-20% of all skin cancers. cuSCC has the best-defined progression from a distinct precancerous lesion, the Actinic Keratosis (AK), to invasive cuSCC. Destructive therapies for AK treatment must be …
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Microrna Functions In Uv-Induced Cutaneous Squamous Cell Carcinoma
<p>Cutaneous squamous cell carcinoma (cuSCC) is the second most common skin cancer, for which long term UV exposure and chronic wounding are the dominant risk factors. Despite these clinically established connections, little is understood about the early molecular response of human skin to UV …
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Regulation and Targeting of Fyn in Human Cutaneous Squamous Cell Carcinoma
… in murine epidermis and is associated with cell-cell adhesion turnover and migration. Introduction of active H-Ras(G12V) into the HaCaT human keratinocyte cell line resulted in upregulation of FYN mRNA (200-fold) and protein, but did not increase the expression of other SFKs. We identified …
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Transforming Growth Factor-Beta Signalling in Human Cutaneous Squamous Cell Carcinoma
… the key pathological driving events in human cutaneous squamous cell carcinoma (cSCC) in order to identify novel therapeutic targets. Already the second most common form of human non-melanoma skin cancer, the incidence of cSCC has continued to rise at epidemic proportions over the past two …
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Understanding the adhesome network in primary and metastatic cutaneous squamous cell carcinoma
Understanding how cancer cells survive, invade and migrate is of fundamental importance to the development of approaches to inhibit invasion and metastasis in patients. Proteins recruited at adhesion complexes, known as the adhesome, are involved in multiple mechanisms which control cancer cell …
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Investigating DNA Methylation Changes in a Preclinical Murine Model of Cutaneous Squamous Cell Carcinoma
… human malignancy. They can be divided into basal cell carcinomas (BCC) and cutaneous squamous cell carcinomas (cSCC), with the latter being responsible for the majority of NMSC deaths. Incidence rates for NMSC are rising due to increased exposure to UV radiation, caused by active sun-seeking …
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Investigating The Roles of Tap63 and Tap73 In Cutaneous Squamous Cell Carcinoma and Lung Adenocarcinoma
… and TAp73 in the development and progression of cutaneous squamous cell carcinoma (cuSCC) and lung adenocarcinoma (LUAC). I have found that TAp63-null (TAp63-/-) mice exhibit increased susceptibility to UVR-induced cuSCC. To identify TAp63-regulated transcriptional programs relevant to the …
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Flower Isoforms Increase Expression in Response to Cellular Stress and Modulate S100 Expression in Cutaneous Squamous Cell Carcinoma Cells
The second most common cancer in humans, cutaneous squamous cell carcinoma (cSCC), affects more than 1 million patients a year in the United States. cSCC arise from keratinocytes of the epidermis or hair follicles. Current treatments are limited, especially for pre-cancerous lesions. Homeostasis …
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Characterization of the expression of angiogenic factors in the feline placenta during development and in feline cutaneous squamous cell carcinoma
… in placental tissue in both fetal and maternal cells of the placenta, suggesting stimulatory interactions between different cell types to promote growth and angiogenesis. Gene expression analysis of placenta revealed upregulation of the pro-angiogenic factor VEGF-A in mid-pregnancy, followed by …
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The Role of Tau in Epidermal Stratification and Differentiation and its Implications in Skin Cancer
… demonstrated to have a more diverse role within cells. Tau is a microtubule associated protein, well studied for its pathological role in Alzheimer’s disease. Recent studies have provided evidence that tau is also expressed in the epidermal compartment of the skin. However, the precise roles of …
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Identification of OATP1B3 as a potential therapeutic target in Recessive Dystrophic Epidermolysis Bullosa Associated Squamous Cell Carcinoma
… are predisposed to developing aggressive cutaneous Squamous Cell Carcinoma (SCC). Unlike SCC in the general population, the primary cause of RDEB associated SCC is not UV-radiation. SCC in RDEB patients has poor prognosis due to a high frequency of recurrence and metastasis. 70% of all …
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Design of Peptide Ligands for 14-3-3ε, and Exploring the Role of Residue Types in Ligand Recognition by 14-3-3 Proteins
… are implicated in various malignancies. In cutaneous squamous cell carcinoma (cSCC), overexpression of the 14-3-3ε isoform is associated with suppression of apoptosis. Like 14-3-3ε, the protein phosphatase cell division cycle 25 A (CDC25A) is over expressed and mislocalized from nucleus to …
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Men and Women are Not Just From Different Planets: The Role of Sex-Based Differences in the Prevention of Non-Melanoma Skin Cancer
… all other cancers. While the risk of developing cutaneous squamous cell carcinoma, the more deadly type of non-melanoma skin cancer, is three times greater in men than women, the mechanisms that contribute to this disparity are unclear. Our previous studies showed that after equivalent, chronic …
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Targeting mutant p53 in cSCCs
Cutaneous squamous cell carcinoma (cSCC) is a type of non-melanoma skin cancer that is the 4th most common cancer registration in Scotland after BCC, lung and breast cancer. Over 30,000 cSCC incidences are reported each year in the United Kingdom. In addition, around 1 in 4 skin cancer deaths in …