Global ETD Search
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Showing 1 to 10 of 10 for “"Cullin-3"”.
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Mechanisms of Controlled Proteolysis during Drosophila Spermatogenesis: Coordinate Action of Apoptotic Caspases and the Ubiquitin-Proteasome System
… this system. We also isolated two members of a Cullin-3-based ubiquitin ligase complex, Cullin-3T and KLHL10. The mutations in cullin-3 were in a specialized intron that splices into a testis-specific isoform, the first characterization of a tissue-specific isoform of this gene. It was the first …
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Analysis of post-translational modifications of the blue light photoreceptor, phot1, by the CRL3NPH3 ubiquitin ligase complex
… interacting protein, can also interact with Cullin 3 (Cul3) as a substrate adapter in a Cul3-based E3 ubiquitin ligase designated CRL3NPH3. We have shown that the CRLNPH3 complex is necessary for the mono/multi- and polyubiquitination of phot1 under high fluence rate conditions in addition to …
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Single cell analysis of Keap1-Nrf2 dynamics
… a Keap1 dimer allowing its ubiquitination in a Cullin-3/Rbx1-dependent manner. In response to electrophiles and oxidants (termed inducers, which bind directly to Keap1) ubiquitination of Nrf2 is inhibited; consequently, Nrf2 accumulates and activates transcription. <br/>We have developed …
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Characterising the mechanism of DCUN1D1 activity in prostate cancer and identifying DCUN1D1 inhibitors for prostate cancer treatment
… modification of majority of the cullin family of proteins with NEDD8. This activity is known to enhance ubiquitination of the cullin RING E3 ligases, however, the extent of the impact of DCUN1D1's activity is underexplored. Studies performed previously in our lab demonstrated the …
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Characterising the mechanism of DCUN1D1 activity in prostate cancer and identifying DCUN1D1 inhibitors for prostate cancer treatment
… modification of majority of the cullin family of proteins with NEDD8. This activity is known to enhance ubiquitination of the cullin RING E3 ligases, however, the extent of the impact of DCUN1D1's activity is underexplored. Studies performed previously in our lab demonstrated the …
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Gitelman & Gordon: Mirror image syndromes reveal the roles of WNKs in blood pressure homeostasis and novel anti-hypertensive targets
… Mutations causing deletion of exon-9 in Cullin-3, which normally ubiquitylates WNKs for degradation, were recently discovered to cause the severest subtype of PHAII (PHA2E) with early onset salt-sensitive hypertension and hyperkalaemia. The reasons for this severity have remained elusive, …
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Vaccinia virus BTB-Kelch proteins
… and Kelch domains function as adapters for the cullin 3 (Cul3)-based E3 ubiquitylation system. VACV BBKs are not essential for viral replication, but they all affect the lesion size induced by infection in an intradermal murine model. Viruses lacking any one of these BBK proteins also induce …
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Dual regulation of transcription factor Nrf2 by Keap1 and the beta-TrCP/GSK-3 in cancer
… substrate adaptor protein that recruits of cullin-3 (Cul3) to Nrf2 via its Neh2 domain. Nrf2 is also negatively regulated by phosphorylation by glycogen synthase kinase-3 (GSK-3) causing β-transducin repeat-containing protein (β-TrCP) to ubiquitinate Nrf2 by Skp1-Cul1-F-box (SCF) ubiquitin …
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Regulation of transcription factors NRF2 and HSF1 in mediating cellular stress responses
… protein (KEAP1), a substrate adaptor for Cullin 3-based E3 ubiquitin ligase. Inducers of the pathway chemically modify specific cysteines within KEAP1, leading to loss of repressor function, NRF2 accumulation and enhanced transcription of genes encoding a large network of cytoprotective …
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Immunometabolism of methyl donors by dairy cattle during periods of negative nutrient balance and heat stress
… analysis. Heat stress increased the abundance of cullin 3, an inhibitor of nuclear factor erythroid 2 like 2, was downregulated by HS, suggesting a decrease in antioxidant responses with HS. The ratio phosphorylated (p):total mTOR tended to be greater with RPM supplementation, suggesting an …