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Showing 1 to 2 of 2 for “"Cullin ligase"”.
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Origins and composition of the cullin-RING E3 ligases in trypanosomes
… E2s and eventually their recruitment to an E3 ligase that will transfer it to the substrate. Cullin-RING is a prominent family of E3 ligases responsible for ubiquitylation of up to 20% of the human proteome. In contrast with the rest of the class, cullin-RINGs perform their function as …
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In vitro reconstitution of the ubiquitylation and disassembly of the eukaryotic replisome
… in the disassembly of CMG were known, viz the E3 ligase SCFDia2 and segregase Cdc48, very little was known about the mechanism of CMG disassembly. In the process of learning more about the disassembly of the replicative helicase from chromatin, I reconstituted the ubiquitylation of CMG and …