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Showing 1 to 5 of 5 for “"Cucurbitacins"”.
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Design, Synthesis, and Biological Screening of Novel Cucurbitacin/ Estrone Analogs Towards Treatment of Melanoma
<p>Cucurbitacins are highly oxygenated tetracyclic triterpene natural products. They are known for their broad spectrum biological activities. Cucurbitacins showed potential activity towards different cancer cell lines with lack of investigation of their activity towards treatment of melanoma. …
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Behavior and Ecology of New and Old World Luperini Beetles (Coleoptera: Chrysomelidae)
… The similar response and adaptation to cucurbitacins by these beetles suggests a common evolutionary origin of these two groups. However, the apparent lack of a common response to Cucurbita blossom volatiles suggests recent evolutionary pathways became substantially different as their …
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I. Isolation and Characterization of Bioactive Compounds From Suriname and Madagascar flora. II. A Synthetic Approach to Lucilactaene
… new cardenolide glycosides, and three known cucurbitacins were isolated from Octolepis aff. dioica (Thymelaeaceae). In addition to these structural studies, a synthetic approach to lucilactaene, a cell cycle inhibitor was developed.
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Investigation onto the Mechanism Behind the Hepatoprotective Effect of Cucurbitacin Compounds
… would be a powerful alternative for treatment. Cucurbitacins (Cucs) are natural triterpenoids known for their potent anticancer and antiinflammatory activities. Recent studies showed that Cucs protect the HepG2 cell line against CCl4 induced toxicity. The mechanism behind this cytoprotection is …
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Design, Synthesis and Biological Screening of Novel Cucsinspired Estrone Analogues Towards Treatment of Hepatocellular Carcinoma
<p>Cucurbitacins (CUCS) are natural products with highly oxygenated tetracyclic triterpenes produced mostly by Cucurbitaceae family plant. They are known for their therapeutic efficiency with different biological activities, such as anti-inflammatory, hepatoprotective and anti-cancer. …