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Showing 1 to 11 of 11 for “"Cucurbitacin"”.
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Investigation onto the Mechanism Behind the Hepatoprotective Effect of Cucurbitacin Compounds
… would be a powerful alternative for treatment. Cucurbitacins (Cucs) are natural triterpenoids known for their potent anticancer and antiinflammatory activities. Recent studies showed that Cucs protect the HepG2 cell line against CCl4 induced toxicity. The mechanism behind this cytoprotection is …
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Design, Synthesis, and Biological Screening of Novel Cucurbitacin/ Estrone Analogs Towards Treatment of Melanoma
<p>Cucurbitacins are highly oxygenated tetracyclic triterpene natural products. They are known for their broad spectrum biological activities. Cucurbitacins showed potential activity towards different cancer cell lines with lack of investigation of their activity towards treatment of melanoma. …
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Disposition of Cucurbitacin as a Factor in Host Plant Selection by Diabroticite Beetles and Electrophoretic Analysis of the Coevolved Genus Cucurbita
… array of metabolites when fed radio-labeled cucurbitacin B. All species excreted the bulk of the cucurbitacin (67.17-94.59% total dpm); permanently sequestered a small proportion of a cucurbitacin D conjugate in the hemolymph (0.98-2.76%); and apportioned the remainder between the gut, the …
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Managing bacterial wilt, caused by Erwinia tracheiphila, on muskmelon with early control of striped cucumber beetle ( Acalymma vittatum (F)), and through varietal selection
… tolerance to BW in both 2015 and 2016. We found cucurbitacin A in leaves of ‘Athena’ and ‘RML9818’, and cucurbitacin B only in leaves and stems of ‘Dream Dew’ and ‘RML9818’. All cultivars had cucurbitacin I in both leaves and stems. In leaves the highest level of cucurbitacin I was found in …
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Pengaruh pemberian buah pare (Momordica charantia L.) terhadap proses spermatogenesis mencit (Mus musculus)
… Bahan aktif yang terkandung didalamnya cucurbitacin termasuk golongan glikosida triterpenoid. Adanya kandungan cucurbitacin ini diduga dapat menurunkan jumlah sel-sel spermatogenik dalam tubulus seminiferus testis mencit (Mus musculus) Penelitian ini merupakan penelitian eksperimental …
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Chemical and molecular analysis of Libyan desert plants used in camel feed
… addition, flavonoids, isoflavonoid derivatives, cucurbitacin, and cucurbitacin glycosides were isolated from these plants. Isolated compounds produced in adequate quantities were screened in vitro for cytotoxic activity against human cancer cell lines: A375 (malignant melanoma), PANC-1 …
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Functional and ecological investigations in Cucurbita: factors mediating fruit infections and insect interactions
… liquid chromatography to quantify cucurbitacin B levels. Both flower availability and cultivar identity strongly influence beetle abundance. Although flowers provide essential feeding sites, inherent cultivar traits significantly modify attraction. These findings demonstrate …
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THERAPEUTIC POTENTIAL OF TARGETING THE FLNA-REGULATED WEE1 KINASE PATHWAY IN ADRENOCORTICAL CARCINOMAS.
… as well as that of the CDK1-cyclin B1 inhibitor Cucurbitacin E, on cell proliferation, viability, and apoptosis; lastly, 3) the combinatorial effect of Plogosertib and Dinaciclib on ACC cells proliferation. Experiments were carried out in four human ACC cell lines, including H295R, MUC-1, TVBF-7 …
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Design, Synthesis and Biological Screening of Novel Cucsinspired Estrone Analogues Towards Treatment of Hepatocellular Carcinoma
<p>Cucurbitacins (CUCS) are natural products with highly oxygenated tetracyclic triterpenes produced mostly by Cucurbitaceae family plant. They are known for their therapeutic efficiency with different biological activities, such as anti-inflammatory, hepatoprotective and anti-cancer. …
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Über die Arc-catFISH-Methode als neues Werkzeug zur Charakterisierung der Geschmacksverarbeitung im Hirnstamm der Maus
… Cycloheximid, Chininhydrochlorid und Cucurbitacin I reagierten. Diese Neurone sind vermutlich an der Steuerung von Abwehrreflexen beteiligt und könnten so die Grundlage für divergentes Verhalten gegenüber verschiedenen Bitterstoffen bilden.
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Effect of Comorbidities on HIV-1 Pathogenesis in Monocytic Cells
… of chemodietary agents like curcumin and Cucurbitacin-D. The present study therefore, illustrates that comorbidities such as smoking and HPV coinfection contribute to HIV-1 replication and pathogenesis in monocytic cells via a CYP-mediated oxidative stress pathway. The study also provides …