Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Cubilin"”.
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Vitamin B12 Bioconjugates In Pharmaceutical Design
… protein intrinsic factor (IF) and its receptor cubilin, and the expression and exploitation of IF/cubilin in pharmaceutical development.</p> <p>Q1: (Chapter 2) Does an 89Zr-B12 conjugate allow for improved background/noise ratio, relative to 99mTc and 64Cu B12 conjugates, in in vivo tumor …
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Toward a Cell-Based Assay for Cubam-Mediated Intrinsic Factor-Vitamin B12 Binding and Uptake
… the AMN expression plasmid and the mini Cubilin-EGFP fusion plasmid; and co-transfecting both plasmids into Ba/F3 cells to complete the model construction. Results: Yeast expression vectors and stable transformants for human, bovine, and platypus IF were successfully obtained, but no …
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Regulation of Human Renal Drug Transporters by Inflammatory Cytokines and Pregnancy-related Hormones in Primary Proximal Tubular Epithelial Cells
… MATE2-K, MRP2, PEPT2, and endocytic receptors (cubilin, megalin), while inducing OCTN1 and MRP1/3. TNF-α reproduced the effects of IL-1β but only on OAT1–3. Functional assays showed concordant IL-1β-driven decreases in OAT1–3, OAT4, and OCT2 activity and increased OCTN1 activity. Mechanistic …