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Showing 1 to 20 of 49 for “"CuAAC"”.
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Conjugation of Anti-HER2 Monoclonal Antibody onto a PLGA-PEG Nanoparticle Using CuAAC Click Chemistry
<p>Methods for attaching targeting ligands to drug delivery vehicles have been under investigation for decades. Antibodies are considered to be the strongest of ligands available in terms of targeting strength and selectivity. The goal of this work is to create an actively targeting and …
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Bioorthogonal Reactions: Synthesis and Evaluation of Different Ligands in Copper Catalyzed Azide-Alkyne1,3-Dipolar Cycloaddition (CuAAC)
… CatalyzedAzide-Alkyne1,3-Dipolar Cycloaddition (CuAAC) reaction has unique features that qualify it to be one of the best click reactions. Its applications have been shown in different aspects and for multiple purposes. The oxidative degradation of biological systems (labile proteins and live …
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Approaches to Asymmetric Click Chemistry
CuAAC 'click' is an invaluable synthetic tool, with asymmetric examples are beginning to emerge. However no rugged asymmetric CuAAC system has to date been discovered. This project aims to develop and utilize asymmetric CuAAC reactions in the synthesis of natural product mimicking macrocycles and …
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A Novel Click Chemistry-Based Method to Detect Hypoxic Tumour Cells and Characterise Their Gene Expression
… copper(I)-catalysed alkyne-azide cycloaddition (CuAAC) with azides. Labelling of hypoxic cells with fluorophore azides, after exposure to SN33267, was optimised in vitro by simultaneously improving hypoxia-selectivity and preserving the integrity of cellular RNA. With the optimised protocol, the …
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Development and investigation of novel chemoselective processes in Pd and Cu catalysis
… of rate independent chemoselectivity in the CuAAC reaction. Chemoselectivity in the CuAAC reaction has chiefly been demonstrated through the use of either activated or deactivated azides, whereas alkyne chemoselectivity is less well developed. Recent work from the Watson and Burley groups …
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Functionalization of Peptide Nucleic Acids via post-synthetic click chemistry
… by copper-catalyzed azide-alkyne cycloaddition (CuAAC) produced the functional MBs. Two pyrene-based quencher-free PNA molecular beacons, a stemless MB and one possessing a stem-loop structure, both targeting a portion of the cystic fibrosis gene, were successfully synthesized by this method. …
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Synthesis of 4-Azidocoumarins and Their Use in Copper-Catalyzed Azide-Alkyne Cycloaddition reactions
… a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. CuAAC reactions of the azides were optimized by screening of various copper catalysts 6 and copper tetrakis acetonitrile hexafluorophosphate ([Cu(CH3CN)4]PF6) gave the best results in the experiments performed. Once the reaction …
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Automated Synthesis of Duplex-Forming Recognition-Encoded Oligomers
… the copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction to trap the species present. LCMS was used to identify the macrocyclic self-complementary duplex as a major product. This trapping approach, as well as <sup>31</sup>P NMR denaturation and Förster resonance energy transfer, were used …
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SALICYLALDEHYDE-TAGGED PEPTIDES FOR THE REVERSIBLE-COVALENT ENGAGEMENT OF PROTEIN LYSINE RESIDUES
… copper-catalyzed azide- alkyne cycloaddition (CuAAC). This second strategy enabled efficient installation of SA moieties onto pre-assembled peptides specific for two protein targets, namely SHP2 and NEMO. Moreover, using human serum albumin as model target, the CuAAC protocol was instrumental …
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Pyrrolo[2,3-d]pyrimidine-based π-conjugated fluorophores with 1,2,3-triazole and ethynyl linkers: synthesis and photophysical properties /
… were prepared by CuAAC reaction. It was demonstrated that in the CuAAC reaction of 2,4-diazidopyrrolo[2,3-d]pyrimidine along with 1,4-disubstituted 1,2,3-triazoles some amounts of 1,5-disubstituted isomers were formed. The synthesized …
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Pirolo[2,3-d]pirimidino π-konjuguotų fluoroforų, turinčių 1,2,3-triazolo ir etinil jungtukus, sintezė ir fotofizikinės savybės /
… were prepared by CuAAC reaction. It was demonstrated that in the CuAAC reaction of 2,4-diazidopyrrolo[2,3-d]pyrimidine along with 1,4-disubstituted 1,2,3-triazoles some amounts of 1,5-disubstituted isomers were formed. The synthesized …
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Design and Synthesis of a Macrocyclic Phospholipid
… Copper-mediated azide-alkyne coupling (CuAAC) using 1,5-diazido-3-oxapentane(bis-azide) afforded a dicarboxylicacid with a hydrophobic chain of sufficient length to span a 35 Å bilayer membrane. The carboxylic acids were each esterified with an equivalent of 10-undecyn-1-ol. After …
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Synthesis of oligonucleotide analogues for use in DNA nanostructures
… azide-alkyne 1,3-dipolar<br/>cycloadition (CuAAC), the best known example of click chemistry, has proven to be of<br/>remarkably broad utility in synthetic chemistry and in nucleic acid chemistry in<br/>particular. CuAAC was exploited for the synthesis of a very stable double …
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A New Approach to Drug Delivery: Non- Peptidic, High Load Macrocyclic Alternatives to Cell Penetrating Peptides
… The copper catalysed alkyne-azide cycloaddition (CuAAC) reaction is also introduced as a tool for functionalising calixarenes. The phenomenon of cell penetration is of interest where a molecule has an intracellular target, for example gene therapy, delivery of cytotoxic agents or cellular imaging. …
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Micro- and millifluidic platforms for imaging agent synthesis
… Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), was utilized to address the concern regarding site-specific attachment of BFCs to BMs. CuAAC, like other “click reactions”, yields products with few side reactions under mild reaction conditions which is key when working with biomolecules. …
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Hydrogen Bond Template-Directed Synthesis of Recognition-Encoded Melamine Oligomers
… A copper-catalysed alkyne-azide cycloaddition (CuAAC) reaction between two REMO 3-mers, bearing 4-nitrophenol recognition units, an alkyne and an azide, was found to be templated by a complementary REMO 6-mer phosphine oxide template. The effective molarity for the intramolecular reaction that …
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Investigations into the Manipulation of 1,2,3-Triazoles and Towards an Asymmetric ‘Click’ Reaction of Meso Bis-Alkynes
… the copper-catalysed azide-alkyne cycloaddition (CuAAC), its mechanistic studies and recent applications. Chapter two contains the results and discussion of the project and begins with the application of the CuAAC reaction to produce a simple 1,4-disubstituted 1,2,3-triazole from its two coupling …
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Molecular and Polymeric Materials Based On Asymmetrically Substituted BF2 3-Cyanoformazanates
… complexes and their incorporation into polymers. CuAAC chemistry was used to synthesize two additional asymmetric BF2 complexes and a side product that was identified as a symmetric dimer. Spectroscopic and electrochemical properties of these compounds are described. Incorporation of an asymmetric …
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Glycoprotein mimetic materials - synthetic methods and study of viral inhibition properties
… copper()-catalyzed alkyne-azide cycloaddition (CuAAC). The tyrosine enrichment required to prepare elastin-like-polypeptides (ELP) proteins for diazo coupling reactions prevented protein expression at 96 pentapeptide repeats and above, but maintained yields comparable to other work at 48 repeats …
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Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular macromolecules
… simple version of the copper-catalyzed analogue (CuAAC). These advances have enabled the rapid synthesis of a library of oligomers with systematic variations in triazole connectivity, allowing us to probe the consequences of sequential connectivity on material properties. In our investigation, we …
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