Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Cu homeostasis"”.
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THE REGULATION OF THE INTESTINAL COPPER EXPORTER IS COORDINATED WITH SYSTEMIC COPPER HOMEOSTASIS
Copper (Cu) plays key catalytic and regulatory roles in biochemical reactions essential for normal growth, development, and health. Defects in Cu metabolism cause Menkes and Wilson’s disease, myeloneuropathy, and cardiovascular disease and are associated with other pathophysiological states. …
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Functional Characterization of Metallothioneins in Arabidopsis and Barley
… binding proteins that can bind metals such as Cu, Zn, and Cd but the functions of MTs in plants are largely unknown. To understand the function of MTs in Arabidopsis, T-DNA insertion mutants lacking 4 MT genes including <em>MT1a, MT2a, MT2b</em> and <em>MT3</em> were developed. The quadruple …
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HSP70 as a Target for Correction of Wilson Disease Causing ATP7B Mutants
Copper (Cu) is an essential micronutrient, which operates as a cofactor of enzymes regulating a wide range of critical physiological processes. However, Cu overload compromises the redox balance in cells and tissues causing serious toxicity. Removal of excess Cu from the body is driven be …
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Storing copper in Streptomyces lividans: structural and biochemical properties of a copper storage protein
Copper (Cu) is essential to the growth and the morphological development of Streptomyces lividans. Understanding how Cu regulates the key development switches in this Gram-positive bacterium has been an area of extensive research. In particular, how Cu homeostasis and regulation are controlled and …
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Characterization of Cu-rich aggregates in neurogenic niches of the rodent brain by X-ray fluorescence microscopy
… neurotransmitter synthesis to ATP production. As Cu is typically present in micromolar concentrations and has a spatially capricious distribution in the brain, determining concentrations has historically been challenging. X-ray fluorescence microscopy (XRF) offers excellent spatial resolution …
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Therapeutic targeting of the ATP7A copper transporter in cancer
[EMBARGOED UNTIL 12/01/2026] Copper (Cu) is an essential micronutrient involved in numerous biochemical processes, including energy production, iron metabolism, cell proliferation, cuproenzyme activity, and collagen crosslinking. Because Cu cannot be synthesized or metabolized by the body, it must …