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Showing 1 to 14 of 14 for “"Ctr1"”.
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Characterization of Drosophila Ctr1a: New Roles for Ctr1 Proteins and Copper in Physiology and Cell Signaling Pathways
… in normal growth, development and physiology. Ctr1 proteins are members of a highly conserved family of copper importers responsible for copper uptake across the plasma membrane. Mice lacking Ctr1 die during embryogenesis from widespread developmental defects, demonstrating the need for …
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Expression and cellular localization of Copper transporter 2 (Ctr2) in Mus musculus
… eukaryotes express two members of this family Ctr1 and Ctr2. Numerous structural and functional studies are available for Ctr1, the only high affinity Cu(I) transporter thus far identified. Ctr1 holigotrimers mediate cellular copper uptake and this protein was demonstrated to be essential for …
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Enhancing Cisplatin Delivery and Anti-tumor Efficacy Using Hyperthermia
… with the role of copper transport protein 1 (Ctr1) in this process. In addition, cisplatin was encapsulated within temperature-sensitive liposomes, which were used in combination with hyperthermia for targeted drug delivery. These studies demonstrated that the combination of cisplatin and …
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The Expression of Copper Transporters in Rat Dorsal Root Ganglion Neurons and its role in Oxaliplatin Neurotoxicity
… of neurons intensely expressing either ATP7A or CTR1, but not both or ATP7B. Neurons expressing the copper influx transporter, CTR1, were more susceptible to oxaliplatin-induced neurotoxicity compared to neurons expressing the copper efflux transporter ATP7A. Based on the abovementioned findings, …
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Inhibition of Cysteine Protease by Platinum (II) Diamine Complexes
… enters the cell through copper transporter CTR1 by passive diffusion and bind to DNA and proteins. Cisplatin is found to inhibit several enzymes targeting cysteine, histidine and methionine residues, which are expected to be responsible for its anticancer activity. A better understanding of …
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The molecular basis for the initiation of fruit development and parthenocarpy
… Constitutive ethylene responses, conferred by ctr1-1, enhanced cellular expansion in fwf and also the autonomous silique development in fis-2, which develops autonomous endosperm. ats ctr1-1 and ino ctr1-1 double mutants were also found to be parthenocarpic. This indicates that ethylene …
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Characterization of a single TRAM domain RNA-binding protein from the Antarctic methanogen Methanococcoides burtonii
… Mbur_0604 and Mbur_1445 are referred to as ctr1 (Ctr1), ctr2 (Ctr2) and ctr3 (Ctr3), respectively. The thesis reports the first experimental studies to assess evolutionary, biophysical and structural properties and unique characteristics related to nucleic acid binding, including specific …
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Investigations into the effects of berry flavonoids on nutrient transport processes in Caco-2 enterocytes
… of genes that coordinate copper uptake (CTR1, HAH1, ATP7A and ATP7B). However, copper uptake was increased by both acute (15 min) and chronic (16 h) berry extract treatment.<br/>Thus overall, there is a clear effect of flavonoids on the pathways of glucose, iron and copper and a possible …
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Application of copper isotope abundance measurements to study copper trafficking in vivo
… with changes in copper transporters. Both CTR1, a protein responsible for copper import, and ATP7A, a protein responsible for copper efflux, were significantly down-regulated in antibiotic-treated mice.
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Isolierung und Charakterisierung von Kupferhomeostase-Faktoren aus Trametes versicolor und deren Einfluss auf die Laccase-Expression
… der S. cerevisiae Deletionsmutanten ∆ctr1 bzw. ∆cup5 mit einer T. versicolor cDNA-Bank isoliert werden. Die aus den beiden Genen abgeleiteten Proteinsequenzen zeigen strukturelle Homologien zu den Proteinen aus der Ctr-Familie und weisen ein in dieser Familie konserviertes MxxxM-Motiv …
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Leveraging copper chelators as targeted therapy for BRAFV600E mutant thyroid cancer
… model. Genetic reduction of the Cu transporter CTR1 in developing tumors also trended towards a survival advantage in mice with BrafV600E-mutant PTC. Finally, TM also enhanced the antineoplastic activity of standard of care clinical BBRAF inhibitor drugs. These results support the clinical …
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Therapeutic targeting of the ATP7A copper transporter in cancer
… and export. The high-affinity Cu transporter 1 (CTR1) mediates cellular Cu uptake, while the P1B-type ATPase ATP7A facilitates Cu transport from the cytosol into the lumen of vesicles or the trans-Golgi network (TGN), where it metalates cuproenzymes such as the lysyl oxidase (LOX) family and …
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Copper at the Interface of Chemistry and Biology: New Insights into hCtr1 Function and the Role of Histidine in Human Cellular Copper Acquisition
… of the human high-affinity copper transporter (hCtr1) contains essential Cu-binding methionine-rich MXXM and MXM (Mets) motifs that are important for copper acquisition and transport. The hCtr1 extracellular domain also contains potential copper binding histidine (His) clusters, including a …
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The Impact of Host Factors on Retroviral Evolution and the Identification of a Novel Receptor That Was Used by an Ancient Primate Retrovirus
<p>The resurrection of inactive endogenous retroviruses allows us to learn about interactions between extinct pathogens and their hosts that occurred millions of years ago. Two of these paleoviruses, chimpanzee endogenous retrovirus 1 and 2 (CERV1 and CERV2), are relatives of modern murine leukemia …