Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Ctdna Detection"”.
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Improving earlier non-invasive diagnosis of high-grade serous ovarian cancer
… developing a diagnostic circulating tumour DNA (ctDNA) biomarker for high grade serous ovarian cancer (HGSOC), was to investigate low-cost high-throughput next generation sequencing assays in plasma samples collected from women with newly diagnosed OC. The secondary aim was to apply these methods …
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Detection of trace levels of circulating tumour DNA in early stage non-small cell lung cancer
… using analytes such as circulating tumour DNA (ctDNA), can detect and quantify cancer in a minimally invasive way and can provide information on tumour heterogeneity. Current limitations in the liquid biopsy field are centred around the general sensitivity of the present assays and the input and …
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Detection and monitoring of treatment resistance in metastatic cancer through non-invasive DNA methylation-based biomarkers
… on empowering plasma circulating tumor DNA (ctDNA) analysis, as a non-invasive approach for precision oncology, with applications ranging from early detection and minimal residual disease (MRD) assessment to dynamic monitoring of treatment response and molecular profiling in advanced disease. …
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Multi-Modality Plasma-Based Detection of Minimal Residual Disease in Triple-Negative Breast Cancer
… the analysis of “liquid biopsies” for early detection of minimal residual disease (MRD) on early-stage TNBC patients using next-generation sequencing. For the first part of this study, I focused on detecting circulating tumor DNA (ctDNA) from TNBC patients after neoadjuvant chemotherapy and …
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Monitoring trace levels of ctDNA using integration of variant reads
In patients with early-stage cancer, ctDNA detection rates can be low due to the presence of few or no copies of any individual mutation in each sample. Sensitivity may be increased by collecting larger plasma volumes, but this is not feasible in practice. Although cancers typically have thousands …
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Amplifying signals in the tumor microenvironment for drug development and diagnostics
… genomic profiling of circulating tumor DNA (ctDNA) molecules in liquid biopsies such as blood. Despite the promise offered by these innovative therapies and monitoring tools, their broad integration into clinical practice faces important challenges. Widespread adoption of emerging therapies …
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Resolving the evolution of Oesophageal Adenocarcinoma using spatial and temporal sampling
… tissue is through circulating tumour DNA (ctDNA). Liquid biopsy sampling also has been proven to be highly prognostic in multiple cancer types and recent advances in ctDNA detection have now provided a potential avenue for this sampling approach to utilised in OAC. Hypothesis Deciphering …
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Surface Plasmon Resonance Imaging Biosensors for Cancer Diagnosis: Detection of Circulating Tumor DNA
… biosensor for the rapid, simple and label-free detection of single point mutations in the KRAS gene, standard actionable cancer biomarkers for colorectal cancer, in human plasma samples. Initially, the SPRI assay included the immobilization of specific peptide nucleic acid (PNA) probes onto the …
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Assessment of the clinical validity of ctDNA Analysis for melanoma management
… are urgently required. Circulating tumour DNA (ctDNA) analysis has emerged as a potential “liquid biopsy” for melanoma. Plasma-derived ctDNA are short DNA fragments released into the bloodstream by apoptotic tumour cells. Studies have shown that ctDNA levels in blood correlate with tumour burden …
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Point-of-care biosensing for rapid and precise biomolecular diagnostics
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01