Global ETD Search
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Showing 1 to 4 of 4 for “"Csm6"”.
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Recovering from Dormancy: Fixation of CSM6-Inducing Spacers in the Bacterial Population
… defense requires the additional activity of Csm6, a non-specific RNase which cleaves both invader and host RNA in the cell. Csm6 activity results in mass RNA degradation which triggers dormancy in the infected cell. How dormancy protects from infection and whether it can be relieved is not …
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Accessory Nucleases Provide Robust Antiparasite Immunity for Type III CRISPR-Cas Systems
… loci typically contain an ancillary RNase, csm6 or csx1. Upon target transcription, the Cas10-Csm complex recognises a viral transcript containing a target, which activates DNase activity of Cas10, leading to the destruction of the invader. In addition, it was recently discovered that the …
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Investigation of Diverse CARF Effectors in Type III CRISPR - Cas Immunity
… the role of canonical CARF effector, Csm6, in mediating immunity against mutant targets. The first proteins I characterized are closely related homologs Chp1 and Chp2 (CRISPR-associated HAD phosphatase). These proteins were first identified in a deep search bioinformatics study.1I …
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CPISPR-CAS: From a Prokaryotic Immune System to a Gene Editing Tool
… first identified a new CRISPR-associated RNase, Csm6. The transcriptional requirement for DNA cleavage created a challenge for host bacteria. When the target was located in a late-expressed phage gene, the phage infection cycle can proceed unchecked until the target was transcribed, resulting in …