Global ETD Search
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Showing 1 to 20 of 39 for “"Cryptococcus neoformans"”.
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Identification and Characterization of a Xylosylphosphotransferase of Cryptococcus neoformans
Cryptococcus neoformans is an environmental yeast and an opportunistic pathogen capable of causing a meningoencephalitis in human hosts. The organism produces an extensive polysaccharide capsule that is unique among pathogenic fungi and absolutely required for its virulence. Work in the Doering …
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Unraveling the genetic determinants of virulence in Cryptococcus neoformans
Cryptococcus neoformans is a fungal pathogen that causes meningitis, primarily in patients who are immunocompromised. It is most common in populations with advanced HIV disease in low- and middle-income countries, especially in sub–Saharan Africa, South America, and southeast Asia. Even with …
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Cell surface analysis of the basidiomycete yeast cryptococcus neoformans
… surface properties of the basidiomycete yeast Cryptococcus neoformans were investigated with a combination of novel and well proven approaches. Non-specific cell adhesion forces, as well as exposed carbohydrate and protein moieties potentially associated with specific cellular interaction, were …
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Pathogen-Specific Adaptations to Conserved Signaling Pathways in Cryptococcus neoformans
<p>Cryptococcus neoformans is an opportunistic fungal pathogen that causes significant disease worldwide. Even though this fungus has not evolved specifically to cause human disease, it has a remarkable ability to adapt to many different environments within its infected host. C. neoformans adapts …
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Disconnecting a Role for DNA Repair in the Pathogenicity of the Human pathogen Cryptococcus neoformans
C. neoformans is an opportunistic fungal pathogen causing fatal meningitis and lung infections. Worldwide every year around 625,000 deaths occur due to Cryptococcosis. A basic understanding of Cryptococcus virulence mechanisms and survival strategies is required to combat the infections and develop …
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The Effects of Host-like Environmental Signals and Gene Expression on Capsule Growth in Cryptococcus neoformans
<p><em>Cryptococcus neoformans</em> is a fungal pathogen that causes cryptococcosis, a disease that kills almost 200,000 people worldwide each year. A unique feature of this deadly yeast is its polysaccharide capsule, which is known to be associated with its virulence. Here, we systematically …
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Structural studies of the capsular polysaccharides from some strains of Klebsiella and Cryptococcus neoformans micro-organisms
… polysaccharides from two strains of c1yptococcus neoformans have been investigated and shovm to be chemically equivalent. The evidence obtained from partial acid hydrolysis, methylation analysis and Smith-degradation studies performed on one of these polysaccharides is consistent with a structure …
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Cryptococcus neoformans e Cryptococcus gattii: quimiotipagem e correlação com criptococose em hospitais públicos de João Pessoa - PB.
… and cosmopolitan, caused by infection with Cryptococcus neoformans (opportunistic) and C . gattii (primary pathogen), whose CNS involvement occurs in a slick. The objecti ve was to verify the diagnosis of infection, species identification, clinical forms, risk factors, geographic …
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Structure-Guided Development of Antifungal Protein Farnesyltransferase Inhibitors and DNA Polymerase Engineering
… two major classes of eukaryotic pathogens. Fungi Cryptococcus neoformans, Candida albicans, and protozoa Plasmodium falciparum are important pathogens from these classes. Although the therapeutics treating infections caused by these species are available, the options of front-line drugs are …
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Niveles de anticuerpos totales y específicos contra proteínas de Cryptococcus neoformans y Cryptococcus gattii en sueros de adultos y niños colombianos con y sin diagnóstico de Criptococosis
Introducción: Cryptococcus neoformans y Cryptococcus gattii causan criptococosis, una micosis potencialmente mortal que mundialmente afecta principalmente a adultos inmunocomprometidos. Objetivo: Contrastar anticuerpos totales y específicos contra antígenos proteicos de C. neoformans y C. gattii en …
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Analysis of clnical features of cryptococcosis and antifungal susceptibility of clinical isolates in Korea
… in immunosuppressed pateint is caused by Cryptococcus neoformans/C. gattii. Cryptococcus neoformans/C. gattii has four subtypes (VNI, VNII, VNIII, VNIV for C. neoformans, VGI, VGII, VGIII, VGIV for C.gattii). Each subtypes shows different geographic distributions and antifungal …
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Practical Approaches to Biological Network Discovery
… network biology in the pathogenic fungus Cryptococcus neoformans. Finally I propose a novel computational method for mapping out transcriptional networks that unifies two orthogonal strategies for network inference. I apply this method to map out the transcriptional network of …
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Molecular Biophysics of Mammalian and Fungal Macromolecular Assemblies
… belonging to the virulent fungal species <em>Cryptococcus neoformans</em>, of which the goal was to obtain biochemical and biophysical insight into the macromolecular complexes involved in human infections, while also potentially contributing towards an eventual method of curing said …
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Macrophage – cryptococcus interactions during cryptococcosis
The human fungal pathogens Cryptococcus neoformans and C. gattii cause life-threatening infections of the central nervous system. One of the major characteristics of cryptococcal disease is the ability of the pathogen to parasitise upon phagocytic effector cells. Cryptococcus can survive and …
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Host-pathogen interactions in the innate immune response of the nematode Caenorhabditis elegans
… to another, the fatal fungal human pathogen Cryptococcus neoformans. We find that this susceptibility trade-off is mediated by the reciprocal activity of two immune genes: the lysozyme lys-7 and the tyrosine kinase abl-1. We suggest that ABL-1 controls two different DAF-16-dependent pathways …
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Immunological evaluation of HIV-negative invasive fungal disease at Groote Schuur Hospital, Cape Town, South Africa
… excluded; with five cases (4 with disseminated Cryptococcus neoformans and 1 with cerebral aspergillosis) undergoing detailed immune work-up. A case of idiopathic CD4 lymphopenia was diagnosed; but all other cases had no evidence of neutrophil or a cell-mediated immune defect; including …
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Novel approaches to the control of infectious diseases
… = 4.0 µg/mL and 9.0 µg/mL, respectively) and Cryptococcus neoformans (IC50 = 4.0 µg/mL and 9.0 µg/mL, respectively). A moderate antimalarial activity against CQ-resistant and CQ-sensitive strains of Plasmodium falciparum was observed, as well. It was also established that 8 possesses anti-HCV …
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Use of Comparative Genomics for Non-coding Rna Prediction and Investigation of Dna Introgression in Yeast
… to identify a non-reciprocal transfer event from Cryptococcus neoformans var. grubii to var. neoformans ~2 million years ago involving a 14 gene (~40 kb) region. The majority of clinical and environmental var. neoformans strains from around the world contain this sequence obtained from var. …
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