Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"Cryptococcus"”.
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Macrophage – cryptococcus interactions during cryptococcosis
The human fungal pathogens Cryptococcus neoformans and C. gattii cause life-threatening infections of the central nervous system. One of the major characteristics of cryptococcal disease is the ability of the pathogen to parasitise upon phagocytic effector cells. Cryptococcus can survive and …
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Intracellular parasitism of macrophages by Cryptococcus
The pathogenic fungi Cryptococcus neoformans and Cryptococcus gattii are two of the main causes of life-threatening meningoencephalitis in immunocompromised and immunocompetent individuals respectively. Following inhalation, cryptococci are engulfed by phagocytic cells in the lung and previous …
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Cryptococcus neoformans e Cryptococcus gattii: quimiotipagem e correlação com criptococose em hospitais públicos de João Pessoa - PB.
… and cosmopolitan, caused by infection with Cryptococcus neoformans (opportunistic) and C . gattii (primary pathogen), whose CNS involvement occurs in a slick. The objecti ve was to verify the diagnosis of infection, species identification, clinical forms, risk factors, geographic …
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Identification and Characterization of a Xylosylphosphotransferase of Cryptococcus neoformans
Cryptococcus neoformans is an environmental yeast and an opportunistic pathogen capable of causing a meningoencephalitis in human hosts. The organism produces an extensive polysaccharide capsule that is unique among pathogenic fungi and absolutely required for its virulence. Work in the Doering …
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Unraveling the genetic determinants of virulence in Cryptococcus neoformans
Cryptococcus neoformans is a fungal pathogen that causes meningitis, primarily in patients who are immunocompromised. It is most common in populations with advanced HIV disease in low- and middle-income countries, especially in sub–Saharan Africa, South America, and southeast Asia. Even with …
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Cell surface analysis of the basidiomycete yeast cryptococcus neoformans
… surface properties of the basidiomycete yeast Cryptococcus neoformans were investigated with a combination of novel and well proven approaches. Non-specific cell adhesion forces, as well as exposed carbohydrate and protein moieties potentially associated with specific cellular interaction, were …
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The emergence of cryptococcus gattii in British Columbia : veterinary aspects
A series of presumed or confirmed Cryptococcus gattii cases diagnosed between 1999 and 2003 was compiled through review of records from veterinary laboratories and human diagnostic services. There was a continual increase in the annual number of animal, but not human, cases diagnosed; no …
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Pathogen-Specific Adaptations to Conserved Signaling Pathways in Cryptococcus neoformans
<p>Cryptococcus neoformans is an opportunistic fungal pathogen that causes significant disease worldwide. Even though this fungus has not evolved specifically to cause human disease, it has a remarkable ability to adapt to many different environments within its infected host. C. neoformans adapts …
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Sex in Cryptococcus: Signaling, Mating-type Locus Evolution and Gene Silencing
… locus (MAT). In the basidiomycetous yeast Cryptococcus neoformans, the pathogen that causes cryptococcal meningitis and cryptococcosis, sex has been associated with virulence. To further understand how sex is genetically regulated in C. neoformans, we focused our studies on the evolution of …
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Niveles de anticuerpos totales y específicos contra proteínas de Cryptococcus neoformans y Cryptococcus gattii en sueros de adultos y niños colombianos con y sin diagnóstico de Criptococosis
Introducción: Cryptococcus neoformans y Cryptococcus gattii causan criptococosis, una micosis potencialmente mortal que mundialmente afecta principalmente a adultos inmunocomprometidos. Objetivo: Contrastar anticuerpos totales y específicos contra antígenos proteicos de C. neoformans y C. gattii en …
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Comparative structural analysis of cytochrome P450 family CYP51 in the genus Cryptococcus
Cytochrome P450 monooxygenase CYP51 (sterol 14α-demethylase) is a well-known target of the azole drug fluconazole for treating cryptococcosis, a life-threatening fungal infection in immune-compromised patients in poor countries. Studies indicate that mutations in CYP51 confer fluconazole resistance …
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Studies on growth and filtration of the antagonistic biocontrol yeast Cryptococcus albidus
A high filtration resistance has been found to hinder the dewatering of the antagonistic biocontrol yeast Crytococcus albidus. Throught literature a hypothesis was developed that the extracellular polysaccharide produced by C. albidus is the major cause of hindrance to the filtration process. …
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Optimising the growth of Cryptococcus species SS1, a potential probiotic for farmed abalone
… a reliable and good quality source of abalone. Cryptococcus species SS1 was isolated from the gut of the South African abalone, Haliotis midae, and has been identified as a potential probiotic for farmed abalone. The implementation of strain SS1 as a probiotic for aquacultured abalone required …
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Optimising the growth of Cryptococcus species SS1, a potential probiotic for farmed abalone
… a reliable and good quality source of abalone. Cryptococcus species SS1 was isolated from the gut of the South African abalone, Haliotis midae, and has been identified as a potential probiotic for farmed abalone. The implementation of strain SS1 as a probiotic for aquacultured abalone required …
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Genome-wide Analyses of Recombination and the Genetic Architecture of Virulence Traits in Cryptococcus
<p>Fungi of the basidiomycete genus Cryptococcus cause disease in an estimated quarter of a million people, annually. Cryptococcus neoformans and Cryptococcus deneoformans are the two most prevalent disease causing species within the Cryptococcus clade, with isolates of these species exhibiting …
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Disconnecting a Role for DNA Repair in the Pathogenicity of the Human pathogen Cryptococcus neoformans
… due to Cryptococcosis. A basic understanding of Cryptococcus virulence mechanisms and survival strategies is required to combat the infections and develop therapies through translational research. Considering the evidence of a role of DNA repair in pathogenesis, I investigated DNA repair …
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Roles of RNA interference and DNA mismatch repair in maintaining genomic integrity in Cryptococcus pathogens
… dissertation begins by introducing pathogenic Cryptococcus species, their ability to mediate disease in humans, and various aspects of their genomes and life cycles. Following the introduction to Cryptococcus, factors known to mediate genomic instability in fungi are described. In Chapter 2, …
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The Effects of Host-like Environmental Signals and Gene Expression on Capsule Growth in Cryptococcus neoformans
<p><em>Cryptococcus neoformans</em> is a fungal pathogen that causes cryptococcosis, a disease that kills almost 200,000 people worldwide each year. A unique feature of this deadly yeast is its polysaccharide capsule, which is known to be associated with its virulence. Here, we systematically …
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