Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Cryptococcal meningitis"”.
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Cryptococcal Meningitis in The Tropics: Defining the Problem and Refining the Management
… of adjunctive dexamethasone in HIV-associated cryptococcal meningitis, in 6 countries in Southeast Asia and Africa. This trial, which demonstrated harm from dexamethasone, is presented in detail in Chapter 6. To contextualize the trial, and to get a better sense of the burden of cryptococcal …
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The Epidemiology, Outcomes, and Prevention of HIV-associated Meningitis in Southern Africa
… in the world, including the first comprehensive meningitis national incidence estimates in a high HIV prevalence country and temporal trends over 16 years with national scale-up of ART. Linking cerebrospinal fluid (CSF) laboratory records of patients evaluated with meningitis to HIV and vital …
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Cognitive outcomes in adults with HIV-associated Tuberculous Meningitis
Tuberculous meningitis (TBM) is a common cause of meningitis in adults in South Africa (1-3), second only to cryptococcal meningitis in studies of microbiologically confirmed meningitis, and accounting for 28% of cases in one (1). Conventional diagnostic tests for TBM are, however, relatively …
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The neuroimmune response to cryptococcal infection
Cryptococcal meningitis (CM) is a fatal fungal infection of the brain that is responsible for up to 20% of all AIDS-related deaths globally, 75% of which are from Sub-Saharan Africa. CM is characterised by debilitating neurological damage often resulting in death or serious longterm sequelae even …
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Characterisation of the Virulence and Determinants of Virulence of <i>C. Neoformans</i> var.<i>grubii</i> Genotypes from HIV Infected and Uninfected Patients in Vietnam
… is the main cause of life-threatening cryptococcal meningitis worldwide, especially in individuals with underlying immunosuppressive conditions such as HIV infection. In contrast to its sister species <i>C. gattii</i> which is now considered a primary human pathogen, <i>C. …
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Development and evaluation of amphotericin B Loaded iron oxide nanoparticles for targeted drug delivery to systemic fungal infections
… invasive fungal infections (IFIs) such as cryptococcal meningitis was designed, developed, characterized, and evaluated. To address the development processes, first, iron oxide nanoparticles (IONP) (34-40 nm) coated with bovine serum albumin (BSA), loaded and targeted with amphotericin B …
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Survival of South-African HIV infected patients
… ); intermediate for oesophageal candidiasis, cryptococcal meningitis, kaposi sarcoma and pneumocystis carinii pneumonia (45%) ; and poorest for the HIV wasting syndrome, AIDS-dementia complex and performance status 4 (20%). Despite the overall poor prognosis associated with the acquired …
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Sex in Cryptococcus: Signaling, Mating-type Locus Evolution and Gene Silencing
… neoformans, the pathogen that causes cryptococcal meningitis and cryptococcosis, sex has been associated with virulence. To further understand how sex is genetically regulated in C. neoformans, we focused our studies on the evolution of the MAT locus and molecular dissection of the …
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Unraveling the genetic determinants of virulence in Cryptococcus neoformans
… neoformans is a fungal pathogen that causes meningitis, primarily in patients who are immunocompromised. It is most common in populations with advanced HIV disease in low- and middle-income countries, especially in sub–Saharan Africa, South America, and southeast Asia. Even with improvements …