Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Cross-regulation"”.
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Cross-regulation and interaction between eukaryotic gene regulatory processes
Regulation of genes is fundamental to all living processes and can be exerted at many sequential steps. We studied several eukaryotic gene regulatory mechanisms with an emphasis on understanding the interplay between regulatory processes on a genome-wide scale. Gene splicing involves the joining of …
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Analysis and design of multiple-output forward converter with weighted voltage control
… Five methods of stacking secondaries to improve cross-regulation are presented, and the improvement of cross-regulation is quantified. A small-signal model of the multiple-output converters with coupled output filter inductors and weighted voltage control is established. The small-signal …
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Dynamics of Cell Fate Decision Making Between Sporulation and Competence in Bacillus Subtilis
… activities of Spo0A and ComK, along with other cross-regulatory genes, simultaneously in single B. subtilis cells. I found that, surprisingly, sporulation and competence progressed independently in the same cell without cross-regulation up to the final decision point. This finding was confirmed …
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Single-inductor, multiple-output buck converter with parallel source transient recovery
… can supply heavy loads while not suffering from cross-regulation problems. The parallel current source circuitry at each output will greatly dampen any voltage spikes that may occur due to sudden load changes, thus improving transient performance. While the entire converter could not be nicely …
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Genetic and Biochemical Studies of YqjH and YqjI: Cross-talk between Iron Homeostasis and Nickel Homeostasis in Escherichia Coli
… systems for individual metals. However, the cross-regulation between different metals is not well-understood. In our study, we focus on the cross-regulation of iron and nickel in bacteria by studying the yqjH-yqjI gene pair in Escherichia coli (E. coli).</p> <p>In E. coli, the yqjH gene …
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Regulation of human sex-linked homologs DDX3X and DDX3Y and phenotypic consequences
… phenotypes, necessitating the study of their regulation. In this thesis, we show that DDX3X is extraordinarily dosage-sensitive, and that perturbation of either DDX3X or DDX3Y expression is buffered -- by negative cross-regulation of DDX3X and DDX3Y in 46,XY cells, and by negative …
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Regulation of elements of the thyroid hormone and corticosteroid systems by stress, hormone treatment, and atrazine during ontogeny of red drum (Sciaenops ocellatus)
… (soGR) hormone receptors and assessed the regulation of these mRNAs by exogenous triiodothyronine (T3) and cortisol. soTR[alpha], soTR[beta] and soGR were expressed in all stages of red drum examined. soTR[alpha] levels increased during the time when surging TH levels have been reported. …
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The Paradoxical Roles of Cell Death Pathways in Immune Cells
… elimination of primed T cells. Understanding the regulation of cell death within immune cells is of vital importance to understanding the immune system and developing therapies against various immune-disorders. In this thesis I have investigated the regulation of cell death and its functional role …
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Multiple regulatory layers in the establishment of Rbfox2 splicing networks
… network and discover determinants of Rbfox2 regulation in mouse embryonic stem cells. We uncovered fundamental principles in the mechanistic aspects of Rbfox-dependent splicing and in the systems-level regulation of interconnected splicing networks. Using high-resolution iCLIP and RNAseq, we …
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Multi-Channel Constant Current (MC3) LED Driver for Indoor LED Luminaries
… and controlled; other strings' currents are cross regulated. Firstly, a PWM half bridge topology is chosen to implement the proposed single-stage MC3 LED driver concept. In order to analyze the current cross regulation, a general model is derived. The circuit has been simulated under various …
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The Role of Glutathione Synthetase in Trypanothione Biosynthesis in Trypanosoma brucei
… decipher whether it has any role in the regulation of these pathways, and assess if it is essential for growth. To determine whether the putative TbGS gene was correctly identified through sequence homology, I cloned and expressed the T. brucei gene (TbGS) in Escherichia coli, and …
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Four-Output Isolated Power Supply for the Application of IGBT Gate Drive
This thesis focuses on the design issues of the multiple-output boost full-bridge converter, which is constructed by cascading the boost regulator with the inductor-less full-bridge converter. The design of the boost regulator has been proposed briefly with component selection and compensator …
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Nutritional Control of L1 Arrest and Recovery in Caenorhabditis elegans by Insulin-like Peptides and Signaling
… genes, with variable dynamics suggesting complex regulation. We identified 13 candidate agonists and 8 candidate antagonists based on expression in response to nutrient availability. We selected ten candidate agonists (daf-28, ins-3, ins-4, ins-5, ins-6, ins-7, ins-9, ins-26, ins-33 and ins-35) …
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Investigation of the TNF superfamily of ligands as potential therapeutic targets in inflammatory bowel diseases
… gene modules that suggested both cytokines can cross regulate components of each other’s receptor-mediated signalling pathways. We confirmed these results through wet-lab experiments and propose the activation of a positive feedback loop when cells are treated with both IFN-γ and TNF-α, leading …
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Exploring a Nuclear Insulin Receptor Signalling Pathway in Drosophila Neural Stem Cells
… the complexity of insulin signalling and its dysregulation across an array of chronic human diseases, this nuclear pathway constitutes an exciting avenue for basic and translational science. Characterising the nuclear actions of InR might offer a more complete understanding of the longer‐term …