Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Cross-presentation"”.
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Cross-Presentation Is A Source of Tumor Antigens For Multiple Myeloma Immunotherapy
<p>Cross-presentation is an essential bridge between the innate and adaptive arms of the immune system where antigen presenting cells (APCs) prime cytotoxic T cell responses. We have recently identified cross-presentation as a mechanism by which solid tumors present exogenous antigens. We therefore …
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Investigating The Role of Quaking In Antigen Uptake and Cross-Presentation By Dendritic Cells
… cells (APC) due to their superior capability of cross-presenting exogenous antigens to CD8<sup>+</sup> T cell for strong adaptive immune responses. They internalize foreign antigens by phagocytosis, endocytosis or macropinocytosis, which are then processed in endosomal compartments and loaded …
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Anti-Nucleic Acid Antibody-Mediated Cross Presentation of An Antigen and Its CD8+ T Cell Activation
Cross-presentation is important for initiating cytotoxic T lymphocyte (CTL) responses against tumors. Delivery of exogenous antigens to the cross-presentation pathway in dendritic cells using a number of different carriers has been attempted to further understand the mechanisms underlying …
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Characterizing The Source of Neutrophil Elastase and Proteinase 3 Cross-Presentation In B-Cell Acute Lymphoblastic Leukemia
… leukemia. Our lab reported that NE and P3 are cross-presented by antigen presenting cells (APCs) and solid tumors, a mechanism whereby exogenous antigens are endocytosed and presented on HLA class I molecules, inducing a cytotoxic T lymphocyte (CTL)-mediated immune response. Therefore, …
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Characterization of endocytic escape pathway and its role in adaptive immunity
… against viruses and tumors, in a process termed cross-presentation. During cross-presentation, dendritic cells present exogenous antigens on MHC class I, and the predominant molecular model for it is one where exogenous antigens are first released from endosomes into the cytosol, and further …
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Yeast-based vaccine approaches to cancer immunotherapy
… for cancer immunotherapy development. Effective cross-presentation of antigen delivered to dendritic cells is necessary for successful induction of cellular immunity. Using a yeast vaccine model, we investigated the phagosome-to-cytosol pathway of cross-presentation. We demonstrate that the rate …
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The role of a pore-forming protein, Mpeg1, in cytosolic import
Cross-presentation is a process by which professional antigen presenting cells acquire exogenous antigens and present them on their surface on MHC class I molecules. This process is key for the initiation of CD8+ T cell responses. Two main pathways for cross-presentation have been described, …
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Processing of Exogenous Hen Egg-White Lysozyme for Presentation on Major Histocompatibility Complex Class I and II Molecules
… complex: MHC) class II system for processing and presentation to CD4+ T cells. Experiments conducted by Michael Bevan in the 1970s demonstrated that exogenous antigen can also enter the MHC class I system and cross-prime CD8+ T cells; the process by which antigen presentation occurs in this …
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Mechanisms of Molecular Chaperone Surface Binding and Endocytosis: Insights into the Molecular Basis for GRP94 Immune Function
… ligands could inhibit GRP94-mediated peptide cross-presentation, suggesting that CD91 played a critical role in this process. While these studies implied that CD91 could function as a GRP94 endocytic receptor, later works suggested that CD91 may not recognize GRP94 at the cell surface. These …
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Batf3-Deficient Mice: Susceptibility to Toxoplasma gondii and Responses to IL-12 Treatment in vivo
… cells are important <italic>in vivo</italic> for cross-presentation of antigens derived from intracellular pathogens and tumors. Additionally, stimulation of IL-12 production by CD8α<super>+</super> DCs has suggested a role for these cells in response to <italic>Toxoplasma gondii</italic> …
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Deciphering the regulation of perforin-2-mediated endocytic escape in dendritic cells
… prime naïve CD8+ T cells in a process known as cross-presentation. Unlike most cell types, cross-presenting DCs have leaky endocytic compartments from where internalised proteins can escape into the cytosol for proteasome-mediated generation of MHC-I-binding peptides. Prior to my project, the …
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Atr-Mediated Cd47 and Pd-L1 Upregulation Restricts Radiotherapy-Induced Immune Priming and Abscopal Responses In Colorectal Cancer
… cells to phagocytose them thereby preventing TAA cross-presentation and innate immune activation. This post-irradiation CD47 and PD-L1 upregulation can be observed across various human solid tumor cells. Concordantly, rectal cancer patients with poor responses to neoadjuvant radiotherapy exhibited …
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Regulation of type I interferons in murine dendritic cells
… are critical for recognition of danger signals, presentation of antigens and control of a spectrum of innate and adaptive immune responses. Type I interferons (IFNs), as important danger signals, activate cDCs through the canonical type I IFN receptor signaling. Type I IFNs are the first line of …
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Engineering novel antibody-based molecules to probe the role of the immunoglobulin hinge and generate a potential cancer vaccine
… B3Z, to investigate the induction of antigen cross presentation. Unfortunately, SIINFEKL incorporated Fc fusion protein was unable to activate B3Z T cells. Further investigation showed that BMDC seems to have a low expression of FcRn receptor, which is crucial for inducing an effective antigen …
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Role of Multiple Toll-Like Receptor Activation in Regulating Cytotoxic T Cell Priming to Lympocytic Choriomeningitis Virus Infections
… to examine if NO can influence MHC-I antigen presentation during viral infections. The data in this section of the thesis provides evidence that combined TLR engagement can alter the presentation of certain CD8+ epitopes due to NO-induced inhibition in proteasome activity. Taken together, the …
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The role of tapasin and its isoforms in antigen presentation and tumor immunity
… 1”) plays a critical role in MHC-I antigen presentation by facilitating peptide loading onto MHC-I molecules in the endoplasmic reticulum (ER). This thesis examines the expression, localization and function of two novel, alternatively-spliced isoforms of human tapasin that lack exon 7 …
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Dendritic Cells Mediate the Dual Effects of IFN alpha/beta in HCV Immunity
… CD8+ T cell priming. Using a human in vitro cross-presentation system, we found that IFNα/β acts on immature DCs (iDCs) to inhibit CD8+ T cell activation by cross-presentation. Further analysis revealed that STAT1-dependent inhibition of CD40-induced IL-12 was responsible for this block. In …
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Immune modulating functions by soypeptide lunasin in cancer immunotherapy
… reaction (MLR). In addition, lunasin enhanced cross-presentation of soluble antigens by mouse CD11c+DCs and CD8α+DCs, resulting in effective priming of antigen-specific IFNγ producing CD8+ T cells. Immunization with etoposide-treated B-lymphoma cells and lunasin provided nearly 100% protection …
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Receptor-Mediated Antigen Delivery by Α<Sub>2</Sub>-Macroglobulin: Effect on Cytotoxic T Lymphocyte Immunity and Implications for Vaccine Development
… for rapid internalization, processing, and presentation. When employed as an Ag delivery vehicle, α<sub>2</sub>M* amplifies major histocompatibility complex (MHC) class II presentation as demonstrated by increased antibody (Ab) titers. Recent evidence, however, suggests that …
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