Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Cross-linker"”.
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On the Interactions of Augmin with Microtubules and the Mechanics of the Cross-Linker PRC1
… interaction level with microtubules; second, the cross-linker PRC1's frictional response resisting motion between two microtubule filaments was analyzed to determine the dependence of the frictional force on the binding conditions of the cross-linker. For the augmin complexes studied sub-second …
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Synthesizing Self-Healing and Recyclable Silicones Using the Diels-Alder Reaction as a Cross-Linker: Investigation of Various Dienes and Dienophile Systems
… the elastomer systems correlated well with the cross-link densities of individual elastomers (elastomers were elongated between 0.3 cm and 2.54 cm). Furthermore, the hardness of the elastomers also correlated with the cross-link density of the elastomer (Shore 00 values ranged from 32 to 8 ). …
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Dynamic viscoelasticity of actin networks cross-linked with wild-type and mutant [alpha]-actinin-4
The actin cross-linker [alpha]-actinin-4 has been found indispensable for the structural and functional integrity of podocytes; deficiency or alteration of this protein due to mutations disturbs the cytoskeleton and results in kidney disease. This thesis presents rheological studies of in vitro …
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Synthesis and antibacterial assessment of water-soluble hydrophobic chitosan derivatives bearing quaternary ammonium functionality
… and an aliphatic, flexible (glutaraldehyde) cross-linkers and their quaternized derivatives exhibited antibacterial activity at low levels of cross-linking. Additionally, gels with rigid cross-linker exhibited enhanced activity compared to the flexible cross-linker. The onset of gelation for …
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Multifunctional Chemical Cross-linkers for Drug Carriers and Molecular Probes
… Broadly, bioconjugation is the use of a chemical cross-linker to covalently attach non-natural reporters, chemical handles, drug cargo, or targeting ligands to biologics to augment their innate properties and functions. Many bioconjugation strategies attach a single non-natural component to the …
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N-Vinylcaprolactam based Bulk and Microgels: Synthesis, Structural Formation and Characterization by Dynamic Light Scattering
… was used as a cross-linker of VCL in solution by radical polymerization. The network formation was investigated by dynamic light scattering. It was shown, that monitoring of the light scattered intensity in all cases is quite sensitive to detect the gelation …
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Polyurethane foams containing renewable castor oil replacement
… replacement. At the same time, the influence of cross-linker contents and isocyanate index on flexible foam was studied. Considering the low reaction rate of castor oil during the synthesis of polyurethane, a specific "heated mold" method was applied. Density, compression force deflection (CFD), …
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A Novel IN SITU Gel for Sustained Drug Delivery and Targeting
… such a gel was found to be quick. Effects of cross-linking on the in vitro drug release from such a system were then investigated. Glutaraldehyde and DL-glyceraldehyde were employed as the cross-linkers. The effect of amount of cross-linking, its type, and reaction time (the elapsed time after …
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Development of novel polymeric nanoparticles with tailored architectures and functionalities/
… to create the brush-arms, and second, cross-linking the arms with a bis-norbornene cross-linker to afford star polymers via the "arm-first" star polymer method. Functionality can be installed into the macromonomer (MM) or crosslinker preand post-polymerization. We took advantage of the …
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Development of a Biaxial Testing System for Research of Soft Tissue Biomechanics using Laboratory Models
… curing temperature, mix ratio of elastomer and cross linker, and addition of curing reagents (n=10 / group) to adjust its tensile strength. However, the lowest ultimate stress that Sylgard 184 could achieve was 15.5 ± 2.3 MPa. Sylgard 170 was the following elastomer to be tested, starting with …
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Synthesis and application of biomaterials containing the 1,3,5-triazaadamantane moiety or functionalized alginate
… small molecule guests. Water soluble TAA cross-linkers were used to make degradable hydrogels by performing photo initiated polymerization and in situ cross-linking with hydrophilic monomers. Hydrogel degradation rates depended on the cross-linker used with degradation times varying from …
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Expansion microscopy : improving imaging through uniform tissue expansion
… probes, to be anchored by a small molecule cross-linker to the gel, so that the method may be carried out entirely with commercial components and standard antibodies.
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Chromatin Structure of Schizosaccharomyces Pombe: From the Lowest to the Highest Orders of Folding
… Equivalent results are obtained using a psoralen crosslinking method for measuring the repeat length in viable spheroplasts. That result, together with other control experiments, rules out many possible artifacts. The measured value of 156 $\pm$ 2 bp is smaller than the length of DNA found in the …
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Synthesis and Characterization of Crystalline Assemblies of Functionalized Hydrogel Nanoparticles
… were made from methacrylated or degradable cross-linker attached HPC. These nanoparticles could be stabilized at room temperature by residual methacrylate or degradable groups are present both within and on the exterior of HPC nanoparticles. Controlled release studies have been performed on …
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Porphyrin Cross-Linkers for Generating Soluble Molecularly Imprinted Polymers from Polyethyleneimine
… porphyrins can be used as an efficient polymer cross-linker, which provides a unique quadruplex DNA binding site in the polymer network. Unfortunately, the high cationic charge density found on PEI has been found to elicit potential dilemmas in the utility of this method. Attempts have been made …
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Biocompatible polymeric nanoparticles for drug/DNA delivery using biologically friendly polymerisation processes
… 2 explores the synthesis of well-defined cross-linked star polymer model networks (CSPMNs) equipped with both acid-labile and non-degradable cores to study potential drug release in acidic conditions. The synthesis of the neutral star polymer precursors to the CSPMNs are also documented. …
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ΙΔΙΟΤΗΤΕΣ ΤΩΝ ΘΕΣΕΩΝ ΔΕΣΜΕΥΣΗΣ L-ΓΛΟΥΤΑΜΙΚΟΥ L-ΑΣΠΑΡΤΙΚΟΥ ΚΑΙ ΚΑΙΝΙΚΟΥ ΟΞΕΟΣ ΕΓΚΕΦΑΛΟΥ ΠΤΗΝΩΝ. "ΣΥΜΒΟΛΗ ΣΤΗΝ ΑΠΟΜΟΝΩΣΗ ΚΑΙ ΧΑΡΑΚΤΗΡΙΣΜΟ ΤΩΝ ΘΕΣΕΩΝ ΔΕΣΜΕΥΣΗΣ L-ΓΛΟΥΤΑΜΙΚΟΥ ΟΞΕΟΣ"
… OF L- [3H]GLUTAMATEBINDING. THE PHOTOAFFINITY CROSS-LINKER HSAB, WAS USED TO ATTACH L-[3H]GLUTAMATE IRREVERSIBLY TO CHICK BRAIN MEMBRANES. ELECTROPHORETIC ANALYSIS WITH SDS-PAGE REVEALED A MAJOR RADIOACTIVE PROTEIN BAND WITH AN APPARENT MR OF 45600 DA. PHOTOLABELING WAS INHIBITED BY QUISQUALIC …
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Synthesis of poly(NIPAM-co-vmbpy) microspheres and transition metal monomers for metallopolymeric material construction
… synthesized for copolymerization with NIPAM and cross-linker methylene-bis-acrylamide in order to attain metallopolymer microspheres with a high percentage of metal incorporation. Synthesis of 4-vinyl-4'-methyl-2,2'-bipyridine (vmbpy) was optimized from literature procedures for usage in the …
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Fabrication and light scattering study of multi-responsive nanostructured hydrogels and water-soluble polymers.
… HPC chains at 23 0C using divinyl sulfone as a cross-linker. The volume phase transition of the resultant HPC microgels has been studied as a function of temperature at various salt concentrations. A theoretical model based on Flory-Huggins free energy consideration has been used to explain the …
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Mass spectrometric indentification of formaldehyde-induced modifications of peptides and proteins under in vivo protein cross-linking conditions
Formaldehyde cross-linking has been used to study protein-protein interactions in cells. Its short spacer arm, ability to permeate through cell membrane and the reversibility of the cross-linking reaction makes this a desirable cross-linker for in vivo studies. Although it has been widely used as a …
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