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Showing 1 to 20 of 89 for “"Cross-link"”.
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The Heme-Lysine Cross-Link of Cytochrome P460: Effects on Catalysis and Mechanism of Formation
… post-translational modification in the form of a cross-link from the peptide backbone onto the porphyrin macrocycle itself. HAO uses a Tyr residue from a neighboring subunit to bind to the porphyrin macrocycle twice, whereas cyt P460 uses a lysine residue to bind to the γ meso carbon once. In cyt …
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Molecular Dynamics Simulations and Cross-Link Analysis of the Rotary Molecular Motor Fo of ATP Synthase
Submitted by Meng Tao (mengtao2@illinois.edu) on 2012-10-23T18:32:04Z No. of bitstreams: 1 Kanchanawarin_Chalermpol.pdf: 331004154 bytes, checksum: 79e6ed6e3fe4628353c529ad121de6ec (MD5)
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Incorporation of cross-link range measurements in the orbit determination process to increase satellite constellation autonomy
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1988.
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Effects of cross-link and myosin motor concentrations on active muscle gel contraction time and extent
… concentration of myosin motors and alpha-actinin crosslinks.
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Molecular Dynamics Simulations and Cross-Link Analysis of the Rotary Molecular Motor F(o) of ATP Synthase
… of ATP in F1 to the proton translocation across Fo which is driven by the electrochemical proton gradient across the membrane. F1 consists of three different subunits in the stoichiometry a1b2c10. So far, only the structure of the c-subunit and a partial structure of the b-subunit have been …
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Exploring the Roles of Heme Type and Histidine -Tyrosine Cross -Link in Heme-Copper Oxidases Using a Myoglobin Model
… may introduce new features such as the Tyr-His cross-linking structure in HCO to the model by direct incorporation of unnatural amino acid(s) into the protein sequence. These strategies demonstrate the power of combining the strength of biological, chemical and modern analytical techniques to …
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Cell-seeded type II collagen scaffolds for articular cartilage tissue engineering
… this thesis were to evaluate effects of scaffold cross-link density and bioreactor culture environment on chondrogenesis in cell-seeded type II collagen scaffolds in vitro, and to begin to test effects of implant compositional maturity (viz. glycosaminoglycan, GAG, content) on chondral defect …
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Nitrate Selective Electrodes Containing Immobilised Ion Exchangers
… astingt echniqueg ave rise to a relatively low cross-link density, two sided response and poor thickness control. The developmenot f a hot pressingt echniquer esolveda ll thesep roblemsa nd would readily suit large scale manufacturing. In this work poly (acrylonitrilebutadiene)( NBr) was …
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The Effects of Electron Radiation on the Glass Transition Temperature of a Polyetherimide
… occurred for a dose of 100 MGy. The cross-link and chain scission densities in the irradiated PEI were determined using infrared spectroscopy. The cross-link density increased with dose for all doses investigated. The chain scission density increased with dose for doses up to 75 MGy, …
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Physical analysis of collagen-GAG composite scaffolds for nucleus pulposus tissue regeneration
… to determine final composition. Chemically cross-linked scaffolds were analyzed to determine pore size and cross-link density. It was determined that every material type contained large enough pore size (275 gm) to seed nucleus pulposus cells and mesenchymal stem cells. The addition of CS to …
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Structural and functional consequences of platinum anticancer drug binding to free and nucleosomal DNA
… to those of a cisplatin-1,2- d(GpG) intrastrand cross-link in double-stranded DNA. The global geometry of cDPCPdamaged DNA is quite different from that of DNA containing a cisplatin 1,2-d(GpG) cross-link. The latter platinated duplex is bent by ~40* toward the major groove at the site of the …
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Comparison of phenanthriplatin, a novel monofunctional platinum based anticancer drug candidate, with cisplatin, a classic bifunctional anticancer drug
… cisdiammineplatinum( Il)-DNA intrastrand d(GpG) cross-link or a cisdiamminephenanthridinechloroplatinum( Il)-DNA dG adduct. Comparison of the repair efficiencies of the two adducts reveals that the diamminephenanthridinechloroplatinum(lI)-DNA dG lesion eludes the nucleotide excision repair …
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Automated data acquisition and analysis for high-resolution Fourier transform mass spectrometry of proteins and peptides
… to membrane proteins, MS analysis of a putative cross-link in the active site of the C-type heme-copper oxygen reductase from Vibrio cholera was performed. Though the sequences in the region differed, other members of the HCO superfamily contained a similar cross-link (confirmed by mass …
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Object-oriented software development in structural engineering
… structural analysis preprocessor called "Cross Link" is developed by the author to demonstrate the application of the object paradigm. Cross Link is intended to provide a unified, easy to use, graphical preprocessing environment that can be used as a front end for any type of finite …
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Cross linked sulphonated poly (ether ether ketone) for the development of polymer electrolyte membrane fuel cell
… of mechanically stable and highly durable cross linked sulphonated PEEK for fuel cell application. The formation of cross linking was confirmed by solvent extraction using the well known Charlsby–Pinner equation. The DSC results indicated that the cross links retard the crystallization, but …
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3-D Computational Investigation of Viscoelastic Biofilms using GPUs
… The EPS consists mostly of bio-polymers, which cross link into a network that behave viscoelastically under deformation. We propose a single-fluid multi-component phase field model of biofilms that captures this behavior, then use numerical simulations on GPUs to investigate the biofilm’s growth …
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Disulfide Cross -Linking in Protein Microspheres
… that disulfide bonds are the covalent cross-link between protein molecules. Mass spectrometry has shown that inter-protein disulfide bonding is not random. The disulfide bonds that do form reflect the electrostatic surfaces of the proteins as they approach each other during …
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Metalloprotein engineering with unnatural amino acids: application in functional heme-copper oxidase and azurin
… forms a post-translational modified His-Tyr cross-link with one of the three histidines at CuB site. Due to the fact that HCO is a large membrane protein with multiple metal cofactors, it is difficult to study and there are many unsolved questions. In particular, since His-Tyr cross-link …
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The synthesis and development of novel, easily processable poly (n-isopropylacrylamide)-based hyrdogels.
… hydrogel liquid (PCPH) spontaneously forms a cross-linked hydrogel that does not re-liquefy upon re-heating, but instead, possesses all of the highly utilisable stimuli-responsive properties typical of PNIPAM-based nanocomposite hydrogels synthesised in situ. This novel methodology …
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STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF THE BACTERIAL FLAGELLAR MOTOR HOOK COMPLEX AND THE MS:C-RING INTERFACE
… characterization of the lysinoalanine (LA) cross-link formation reaction catalyzed by Td FlgE. Therein, I present the structures of all three protomeric states along the LA cross-linking formation pathway, including wild type (WT), the dehydroalanine (DHA) intermediate and the LA …
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