Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Cross-Seeding"”.
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The Molecular Interaction Between Type Ii Diabetes and Alzheimer’S Disease Through Cross-Seeding of Protein Misfolding
… and accumulation of these proteins follows a seeding-nucleation model where misfolded soluble oligomers act as nuclei to propagate misfolding by recruiting other native proteins. Cross-seeding occurs when oligomers composed by one protein seed the aggregation of a different protein. Our …
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Cross-Seeding Potential of Misfolded Amyloid-Beta Strains On Tau Protein: Examining The Puzzle Pieces of Alzheimer'S Disease
<p>Alzheimer’s disease (AD) is a neurodegenerative disorder that will progressively impair cognitive function. AD is the leading source of dementia, and affects one third of the senior citizens in the United States. Aging is the primary risk factor for AD and due to the expected rise in human …
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Probing the conformational dynamics of amyloid oligomers in biologically relevant microenvironments
… for their propensity to form fibrillar cross-β structures, are both physiologically functional and implicated in the development of diseases, such as Alzheimer's disease (AD). It is generally accepted that metastable oligomers are the principal cytotoxic species, which permeabilize …
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Pathogenesis of Neurodegenerative Diseases via Templated Recruitment
… To test whether fibrillar α-syn can directly cross-seed tau into pathological aggregates, we utilized our recently developed synucleinopathy models in primary neurons and transgenic mice involving delivery of α-syn pffs. Intriguingly, we discovered two distinct strains of α-syn fibrils …
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Getting Insight into the Molecular Determinants of Foldopathies
… (metal ions and oxidative reactive species) and cross-seeding among amyloidogenic proteins. Since the protein aggregation is a common pathological pathway, the biochemical events that may affect this process are investigated, either singularly or in combination. The proteins alpha synuclein and …
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Factors modifying the aggregation of atrophin-1 acting in cis and in trans
… neuroblastoma N2a cells. Furthermore, our novel cross-seeding approach which allows for monitoring of the architecture of the aggregate core directly in the cell revealed an evolution of the aggregate core of the polyQ-expanded ATN1 from one composed of the sequences flanking the polyQ domain at …