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Showing 1 to 20 of 134 for “"Cross-Coupling Reactions"”.
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Cross-coupling reactions of unactivated alkyl halides
… development of palladium- or nickel-catalyzed cross-coupling reactions using unactivated alkyl electrophiles (e.g., halides and sulfonates). Although aryl and alkenyl electrophiles have been commonly used in such processes, the utility of alkyl substrates has been underdeveloped, and merits …
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METAL-CATALYSED CROSS-COUPLING REACTIONS OF NITROGEN HETEROCYCLES
… imidazole and pyrrole. The products of these reactions then undergo palladium-catalysed C-C cross-couplings with aryl or heteroarylboronic acids under Suzuki-Miyaura conditions to provide a rapid entry to tris(hetero)aryl scaffolds comprising two or three N-heterocyclic rings. The sequential …
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Palladium catalyzed cross-coupling reactions of allyl- and vinylsilanes
Palladium-catalyzed cross-coupling of γ-substituted allylic silanolates with aryl bromides was investigated. It was discovered that γ-selectivity is heavily influenced by the substituents at silicon. It is proposed that undergoing an activated pathway significantly lowers the selectivity of the …
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Transition metal-catalyzed cross-coupling reactions of functionalized organometallic reagents
… have been found for a versatile nickel-catalyzed crosscoupling reaction in the presence of an electron deficient styrene promoter, allowing for the first time: · effective coupling of readily available functionalized alkylzinc halides and benzylic zinc bromides with functionalized alkyl iodides in …
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Photoredox C–C Cross-Coupling Reactions using Boronic Acid Derivatives
… derivatives and subsequently engage them in C–C cross-coupling reactions. In the first chapter, an introduction to photoredox catalysis and organoboron reagents is provided, as well as a discussion on the key mechanistic aspects of photoredox catalysed C–C cross-coupling reactions. The second …
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Development and application of transition metal-catalyzed cross-coupling reactions
Chapter 1. PALLADIUM-CATALYZED REGIOSELECTIVE HYDRODEBROMINATION OF DIBROMOINDOLES A novel approach to the selective preparation of 4-bromoindoles has been developed via a Pd-catalyzed reaction. A variety of 4,6-dibromoindoles, which are prepared via Cu-catalyzed chemoselective C-N bond-forming …
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Palladium-catalyzed C-N and C-O cross-coupling reactions
… its dialkyl- or diarylbiaryl analogues. The C-N coupling was efficient for a wide range of (hetero)aryl chlorides and bromides under mild conditions. Chapter 2: This chapter relates the development of the Pd-catalyzed C-O coupling of primary alkyl alcohols. The reaction of primary aliphatic …
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Nickel-catalyzed cross-coupling reactions involving secondary and tertiary alkyl nucleophiles
… introduction of transition metal-catalyzed cross-coupling reactions has been given. These transition metal-catalyzed C-C bond forming reactions have been used extensively in organic synthesis. Among them, C(sp2)-C(sp2) bond forming reactions have been widely studied over decades. More …
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DEVELOPMENT OF BASE METAL-CATALYZED HYDROGEN TRANSFER AND CROSS-COUPLING REACTIONS
… is focused on (i) the use of iron catalysts for reactions involving hydrogen transfer and (ii) the development of nickel-catalysed C-heteroatom coupling reactions following the ‘metallaphotoredox’ approach exploiting readily available organic photocatalysts. Thanks to their attractive features, …
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Palladium-Catalyzed Alkenylsilanol Cross -Coupling Reactions: Method Development and Mechanistic Analysis
… as the turnover-limiting step for these cross-coupling reactions.
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Mechanistic Elucidation of M-PR2NRʹ2 Catalysts for Hydrofunctionalization and Cross Coupling Reactions
… transformations. Alkyne hydrofunctionalization reactions, including hydroamination and hydroalkoxylation, were previously catalyzed with [Ru(Cp/Cp*)(PR2NRʹ2)(MeCN)]PF6 catalysts. However, validation of the proposed mechanistic pathway for these complexes has not yet been realized. Investigation …
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Development and Applications of Pd Catalysts for C-N Cross-Coupling Reactions
… excellent reactivity and efficiency in the coupling of a variety of amides and anilines with aryl chlorides. Chapter 2 A new class of one-component Pd precatalysts bearing biarylphosphine ligands is described. These precatalysts are air- and thermally-stable, are easily-activated under …
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Development of novel transition metal-catalyzed cross-coupling reactions and applications thereof
Chapter 1 The first example of Pd(0)/(II) catalyzed fluorination of aryl bromides is reported herein. Based on these data, an analogous method was developed for the fluorination of aryl triflates. The reaction proceeds under mild conditions and represents the first report of reductive elimination …
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Development of Cobalt and Nickel N-Heterocyclic Carbene Complexes for Cross-Coupling Reactions
Cross-coupling, which relies on the use of transition metals, is among the most utilized chemical means of establishing carbon-carbon or carbon-heteteroatom bonds between appropriately functionalized sp, sp2, or sp3 centres. However, most cross-coupling reactions rely on the use of palladium to …
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Development of transition metal-catalyzed C-S and C-C cross-coupling reactions
… carbon-carbon and carbon-heteroatom bond forming reactions are important and fundamental transformations in synthetic organic chemistry. These reactions have been widely used for a variety of cross-coupling reactions of aryl halides in the processes of C?C, C?N and C?S bond forming reactions. In …
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Synthesis of Biologically Active Tropolones and Stereochemically Rich Compounds via Cross-Coupling Reactions
… troponoid-benzenoid compounds, through cross-coupling reactions, paves the way for entry into a whole new ligand class and asymmetric catalysis in contrast to the abundant benzenoid based privileged ligands.</p> <p>The Biscoe lab studies asymmetric C–C bond formation utilizing …
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Development of Deactivation-Resistant Catalysts for Pd-Catalyzed C–N Cross-Coupling Reactions
Chapter 1: Introduction to Pd-Catalyzed C–N Cross-Coupling: Rational Biarylphosphine Ligand Design Enhances the Reactivity of Difficult Substrates Transition-metal-catalyzed C−N cross-coupling reactions are an important class of transformations with applications in a variety of fields, and Pd-based …
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Palladium- and nickel-catalyzed C-N cross-coupling reactions featuring soluble organic bases
… Enables the Use of a Common Soluble Base in C-N Coupling Due to the low intrinsic acidity of amines, palladium-catalyzed C-N cross-coupling plagued continuously by the necessity to employ strong, inorganic, or insoluble bases. To surmount the many Due to the low intrinsic acidity of amines, …
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Preparative and mechanistic aspects of palladium-catalyzed cross-coupling reactions of alkali-metal arylsilanolates
… of a large number of arylsilanols undergo smooth cross-coupling with a wide range of aromatic bromides and chlorides. The critical feature for the success of these coupling reactions and their considerable scope is the use of bis(tri-tert-butylphosphine)palladium. Additionally, these studies have …
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