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Showing 1 to 20 of 78 for “"Cross-Coupling Reaction"”.
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Development of organosilicon cross-coupling reaction
Use of palladium catalyzed cross-couplings have found widespread use in the pharmaceutical industry and there is a significant ongoing effort to either improve or devise new synthetic strategies to help build complex biologically active compounds. This is a study for advancing the use of silanols …
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Mechanistic studies on palladium-catalyzed C-N cross-coupling reaction
… on the palladium catalyzed C-N bond-forming reaction were carried out to generate a more complete understanding of the catalytic cycle. To understand this reaction, several kinetic studies employing simple aryl halide and amine coupling partners were performed to elucidate unknown reaction …
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Studies on the Silanol-Based Cross-Coupling Reaction: (1) Development of Methods for the Synthesis of Aryl and Heteroaryldimethysilanols, (2) Expansion of the Substrate Scope of the Cross-Coupling Reaction and (3) Investigations on the Transmetalation of Organosilanols to Transition Metals
… been designed, synthesized and subjected to the cross-coupling reaction. A clear preference for formation of the cross-coupling products was observed in these investigations.
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[3+2]-Cycloadditions of Azomethine Imines and Ynolates and Progress Towards a Radical Three-Component Cross-Coupling Reaction
… second chapter describes attempts to render the reaction asymmetric, which proved to be difficult. Future ideas to improve yields and to render the reaction asymmetric are also described. The last chapter involves progress towards a novel three-component, enantioselective radical cross-coupling …
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A Stereospecific Pd-Catalyzed Suzuki Cross-Coupling Reaction and a Statistical Study of the Ligand's Role in Stereoselection
… development of palladium-catalyzed carbon-carbon cross-coupling reactions has profoundly influenced the manner through which we approach the synthesis of complex organic molecules. Among established cross-coupling reactions, which include Kumada, Negishi, and Stille reactions, the Suzuki …
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Transmetalation from boronic esters to arylpalladium complexes without prior hydrolysis – mechanistic studies and preparative applications in the anhydrous, Suzuki-Miyaura cross-coupling reaction
… the development of transition-metal catalyzed, cross-coupling reactions has fundamentally changed the way chemists think about C–C bond formation. Within the class of transition-metal catalyzed, cross coupling reactions, the Suzuki-Miyaura reaction has emerged as the most popular method because …
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Transition metal-catalyzed cross-coupling reactions of functionalized organometallic reagents
In summary, reaction conditions have been found for a versatile nickel-catalyzed crosscoupling reaction in the presence of an electron deficient styrene promoter, allowing for the first time: · effective coupling of readily available functionalized alkylzinc halides and benzylic zinc bromides with …
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Palladium catalyzed cross-coupling reactions of allyl- and vinylsilanes
Palladium-catalyzed cross-coupling of γ-substituted allylic silanolates with aryl bromides was investigated. It was discovered that γ-selectivity is heavily influenced by the substituents at silicon. It is proposed that undergoing an activated pathway significantly lowers the selectivity of the …
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Ligand design principles for perfecting stereoretention in Suzuki-Miyaura cross-coupling of unactivated CSP3 boronic acids
… challenge in building block assembly is finding reactions to forge carbon-carbon bonds between a range of structurally diverse building blocks. Iteration of metal-mediated cross-coupling reactions represents a promising direction, and such an approach has already been automated and used to make …
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Palladium-Catalyzed Cross -Coupling Reactions of Organosilanolates: Methods Development and Application in the Total Synthesis of (+)-Papulacandin D
… silyl substituents were differentiated in the cross-coupling reaction through the initial use of base-promoted reaction conditions where only one silyl group was reactive with a range of aryl halides. The second silyl substituent then reacted under fluoride-promoted reaction conditions to …
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The synthesis and applications of a biaryl-based asymmetric phosphine ligand
… ligand to the asymmetric Suzuki-Miyaura cross-coupling reaction was also investigated. This phosphine ligand has yielded promising results in the asymmetric Suzuki-coupling of hindered boronic acids with the electron-rich aryl bromide, 1-bromo-2- methoxynaphthalene, to synthesize biaryls …
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The selective palladium-catalysed decarboxylative coupling of nucleophiles in the presence of propargylic electrophiles
… chemo- and regioselective decarboxylative coupling of 1,3-dicarbonyl compounds and nitrogen nucleophiles in the presence of propargylic electrophiles. The first part of this thesis focuses on the palladium-catalysed cross-coupling reaction involving two 1,3-dicarbonyl compounds in a regio- …
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The Development of Sequential Silylcarbocyclization Silicon-Based Cross -Coupling Reactions and Their Application in the Total Synthesis of Isodomoic Acid H
… with a palladium-catalyzed, silicon-based cross-coupling reaction has been developed. 1,6-Enynes reacted with benzyldimethylsilane in the presence of rhodium catalysts to afford five-membered rings bearing a (Z)-alkylidenylbenzylsilyl group. A variety of substitution patterns and heteroatom …
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The Development of Sequential Silylcarbocyclization Silicon-Based Cross-Coupling Reactions and Their Application in the Total Synthesis of Isodomoic Acid H
… with a palladium-catalyzed, silicon-based cross-coupling reaction has been developed. 1,6-Enynes reacted with benzyldimethylsilane in the presence of rhodium catalysts to afford five-membered rings bearing a (Z)-alkylidenylbenzylsilyl group. A variety of substitution patterns and heteroatom …
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The 1,3-Diazabiphenylene system. synthesis, chemistry, and incorporation into a linearly extended purine analogue
… via a heteroaromatic cross coupling reaction, is discussed.
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Computational study on the origins of asymmetric induction in Pd-catalyzed cross-coupling reactions and suggestions for improvements thereupon
… of asymmetric induction in the Suzuki-Miyaura cross coupling reaction are investigated computationally with density functional theory. Monophosphine-bound palladium complexes are analyzed in the context of oxidative addition to aryl halides, and ligands are explored in terms of steric and …
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One-Pot Synthesis of meta-Substituted Phenols via Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling and Oxidation
… both steps of the synthesis, which includes a cross-coupling reaction between -chlorocyclohexenones with boronic acids, followed by aerobic oxidation of the resulting enone. This method is also suitable for the synthesis of meta- and ortho-disubstituted phenols, which have so far been …
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Synthetic Strategies Towards Pi-Extended Dithienophospholes Available for Click Chemistry
… the dithienophosphole scaffold first, then cross-coupling onto the 2,6-positions, then modifying the acetylene to be able to perform click chemistry saw many difficulties. An alternative route was explored where the cross-coupling reaction with a brominated bithiophene was performed first, …
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