Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Cromakalim"”.
-
Functional cell biology and molecular pharmacology of ATP sensitive potassium channels.
… analogues whereas the K ATP COs typified by cromakalim are insensitive to L-arginine analogues. This sensitivity appears to be independent of nitric oxide synthase (NOS) action as the vasorelaxant and Rb efflux responses to pinacidil are insensitive to the NOS inhibitor L-N5-(1-iminoethyl) …
-
Studies on the role of the autonomic nervous system in airway hyperreactivity.
… to AH, in a guinea-pig model of asthma. Cromakalim, a potassium channel opening drug, attenuated vagally-mediated constriction in vitro in both normal and sensitized guinea-pig trachea, suggesting that the pre-junctional K+ - channels involved in modulating vagal tone are functioning …
-
Spontaneous tone in deoxycorticosterone acetate-salt hypertensive rats
… effect likely mediated by its COX metabolites. Cromakalim, a KATP channel opener, abolished spontaneous tone in a glibenclamide-sensitive fashion. In aortic cells from DOCA-salt hypertensive rats, ATP-dependent K+(KATP) channel currents were either absent or weak in response to challenges by …
-
Adrenergic-cholinergic interactions in the heart
… The potassium channel openers, pinacidil and cromakalim, did not have any inhibitory effect on the isoproterenol-induced positive inotropy but inhibited ina concentration-dependent manner the positive inotropic responses to phenylephrine. Uncoupling of muscarinic receptors from adenylate …