Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Crohn s Disease"”.
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IDENTIFICATION OF ADHERENT-INVASIVE ESCHERICHIA COLI (AIEC) VIRULENCE DETERMINANTS LEADING TO ACTIVATION OF PATHOGENIC TH17 CELLS IN CROHN¿S DISEASE.
Crohn’s disease (CD) is a chronic inflammatory bowel disease characterized by a relapsing-remitting clinical behaviour resulting from inappropriate and persistent activation of the gut mucosal immune system in genetically predisposed individuals. So far, the accepted dogma is that CD arises from …
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Indications and outcomes of abdominal surgery in patients with Crohn s Disease attending a tertiary hospital: a single centre study
Background: Crohn's disease is a chronic inflammatory and heterogenous condion affecting predominantly the small bowel. Despite optimal medical therapy, it is associated with lifethreatening complications related to inflammation or fibro-stenotic disease that often require surgery. The aim of this …
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DUAL TARGETING OF RFAP AND FIMH IMPAIRS AIEC INTRACELLULAR SURVIVAL AND LIMITS OMV-DEPENDENT IL-23/PTH17 AXIS ACTIVATION, OFFERING A NOVEL THERAPEUTIC STRATEGY FOR CROHN¿S DISEASE
Crohn’s disease (CD) is a chronic inflammatory disorder characterized by an aberrant inflammatory response against a dysbiotic gut microbiota. Especially, intestinal enrichment of the adherent-invasive Escherichia coli strain (AIEC), together with a dysregulated activation of the IL-23/pTh17 axis, …
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Intestinal permeability to polyethylene glycol 400 in patients with Crohn's disease
… factor in the pathogenesis of inflammatory bowel disease. The relevant literature was reviewed. Intestinal permeability to Polyethylene glycol 400 in patients with Crohn' s disease, their relatives and healthy controls was examined and the data compared with studies of small bowel permeability to …
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A molecular genetic analysis of Crohn’s disease susceptibility loci in psoriasis
… and association studies have identified a major disease susceptibility locus (PSORS1) and several genetic determinants of smaller effect. At least two of these (the IL12B and IL23R genes) have independently been associated with Crohn’’s disease (CD). Thus, the aim of this project was to …
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FOXP3, ICOS and ICOSL polymorphisms in an Italian population affected by systemic sclerosis
… this SNP and susceptibility to other autoimmune diseases in individuals of European ancestry. Autoimmune diseases studied included psoriasis, celiac disease, Crohn s disease, ulcerative colitis, multiple sclerosis, vitiligo, type-1 diabetes, rheumatoid arthritis, and ankylosing spondylitis. …
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L'infiammazione intestinale nell'animale sperimentale come modello per lo sviluppo di nuovi farmaci: ruolo della via tachichininergica nelle malattie infiammatorie intestinali
… increased in patients with inflammatory bowel disease, and similar changes were observed in experimental models of inflammation. The 2,4 Dinitrobenzene Sulphonic Acid (DNBS) model of colitis is useful to study innate immunity, non-specific inflammation and wound healing; it has been suggested …
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Antikörper gegen Saccharomyces cerevisiae bei Morbus Crohn
… gegen Saccharomyces cerevisiae bei Morbus Crohn - eine Familienstudie Einleitung: Antikörper gegen Saccharomyces cerevisiae (ASCA) stellen einen spezifischen und sensitiven Marker für Morbus Crohn (MC) dar. Die Ursache für die krankheitsspezifische Prävalenz dieser Antikörper ist ungeklärt. …
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Identification of novel genetic determinants in the high prevalence early-onset inflammatory bowel disease population in Scotland
Background & aims: The inflammatory bowel diseases (IBD), Crohn‟s disease (CD) and ulcerative colitis (UC), are common causes of chronic gastrointestinal morbidity, affecting up to 1 in 250 of the general population in Northern Europe. Up to 25% of IBD is diagnosed during childhood or adolescence. …
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The role of matrix metalloproteinases and their inhibitors in irinotecan-induced oral mucositis: an animal model.
… some pathophysiological aspects of several diseases including some diseases of the oral and gastrointestinal mucosae. These mucosal diseases include ulcerative colitis, Crohn‟s disease, recurrent aphthous stomatitis and oral lichen planus. However, as MMPs and TIMPs have not been well …
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Survival Of Mycobacterium Avium Subspecies Paratuberculosis In The Pol
… it is the known etiological agent of johne's disease in ruminants and implicated in the etiology of crohn's disease in humans. Map's ability to survive within macrophages enables it to disseminate throughout the rest of the host, possibly infecting other circulating blood leukocytes. In this …
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Expression And Characterization Of Mycobacterium Paratuberculosis 19kda With Posttranslational Modification
… were evaluated against T-lymphocytes from Crohn's disease patients and normal controls. T- proliferation assay included controls such as PHA and PPD from M. paratuberculosis. There was not a significant difference between the two forms of the protein (16/19 kDa) against T-cell response from …
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Differentialdiagnose der chronisch entzündlichen Darmerkrankungen Morbus Crohn und Colitis ulcerosa anhand der Autoantikörper pANCA, PAK und ASCA
Die Differentialdiagnose Morbus Crohn – Colitis ulcerosa kann gelegentlich Schwierigkeiten bereiten. Bislang gibt es keine serologischen Marker, die ausreichend spezifisch und sensitiv sind, um eine sichere Diagnosestellung dieser Erkrankungen zu ermöglichen. In der vorliegenden Studie wurde die …
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Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease
… such as indole-3-carbinol (I3C) and indirubin. Crohn's disease, a chronic inflammatory state of the gastrointestinal tract, affects millions worldwide; however, the exact cause is unknown and treatments do not cure the disease. The role of the AhR in mucosal immune responses is not well …
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Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease
… such as indole-3-carbinol (I3C) and indirubin. Crohn's disease, a chronic inflammatory state of the gastrointestinal tract, affects millions worldwide; however, the exact cause is unknown and treatments do not cure the disease. The role of the AhR in mucosal immune responses is not well …