Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 100 for “"Crohn’s disease"”.
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A molecular genetic analysis of Crohn’s disease susceptibility loci in psoriasis
… and association studies have identified a major disease susceptibility locus (PSORS1) and several genetic determinants of smaller effect. At least two of these (the IL12B and IL23R genes) have independently been associated with Crohn’’s disease (CD). Thus, the aim of this project was to …
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Key Genotypes and the Response to Nutrient Supplementation in Crohn’s Disease
Background New Zealand has high rates of Crohn’s disease (CD) at 26/10. Having gene variants associated with low levels of betacarotene, vitamin D and Omega-3 polyunsaturated fatty acids can impede the immune response. Not known is the prevalence of these variants in a New Zealand CD population. …
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Rare Variant Association Studies In Crohn’S Disease and Colorectal Cancer: Methods and Applications
… factors account for a substantial portion of Crohn’s disease and colorectal cancer (CRC) risk. Patients with Crohn’s disease, a condition that causes chronic inflammation of the gastrointestinal tract, are at increased risk of colorectal cancer morbidity and mortality. Genome-wide association …
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Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn’s Disease
The inflammatory bowel diseases (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract. Their aetiology is not fully understood but is thought to be a combination of the effect of environmental factors in a genetically …
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Use of transgenic mice to study the role of autophagy protein ATG16L1 in Crohn’s Disease
Crohn’s disease (CD) is a chronic inflammatory bowel disorder that primarily affects the ileum and colon. CD aetiology is complex, with the current most widely accepted hypothesis being that disease onset is triggered by environmental factors that alter the intestinal microbiota and abnormally …
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Microbial, immunological, phenotypic and genetic markers of risk: aspects of Crohn’s disease that are shared by unaffected siblings
Crohn’s disease (CD) is an incurable intestinal disorder in which an immune response driven by commensal gut microbiota leads to chronic inflammation. Why this occurs in specific individuals is unclear; however, a genetic predisposition is fundamental and relatives of patients with CD are at …
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Comparison of Health-related Knowledge and Quality of Life in Outpatients with the Crohn’s Disease and Ulcerative Colitis
… 하였다. 연구 도구는 질병 관련 지식은 Eaden 등(1999)이 개발한 The Crohn's and Colitis Knowledge(CCKNOW) Score를 연구자가 번역과 역번역한 한국판 도구로 측정하였다. 건강 관련 삶의 질은 Irvine, Zhou와 Thompson(1996)의 Short Inflammatory Bowel Disease Questionnaire (SIBDQ)를 대한장연구학회(2003)가 번안한 한국판 도구로 측정하였다. 본 연구의 주요 결과는 다음과 같다. 1. 본 연구에 참여한 크론병과 궤양성 …
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The effects of bile acid sequestrants on the microbiome in the diagnosis and management of bile acid diarrhoea and post-operative Crohn’s disease
… conditions such as post-cholecystectomy and Crohn’s disease, where it is found in over 90% of patients following a terminal ileal resection. A major limitation to recognising and acknowledging this disease is the lack of available diagnostic modalities. The treatment for this condition is …
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Evolution of Surgery Risk in Crohn's Disease
While many individuals with Crohn’s disease require surgery for management, the risks of surgery are not well characterized in population-based studies. Advances in medical management may have influenced the risk of surgery over time. However, studies have not adequately evaluated the effect of …
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The Impact of Study Methodology on Studying Genetic and Environmental Risk Factors for the Inflammatory Bowel Diseases
Inflammatory bowel disease (IBD), comprised of Crohn’s disease and ulcerative colitis, results from a complex interaction between genetic and environmental factors. NOD2 and cigarette smoking are two of the most commonly replicated genetic and environmental risk factors, respectively, for Crohn’s …
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Microbial Manipulation as a Therapy in Crohn's Disease
Crohn’s disease is a chronic relapsing inflammatory disease of the gastrointestinal tract. Its global incidence and prevalence rates have risen over the last two generations; its burden reflects this rising. Physical, social and psychological morbidity result in reduced quality of life and …
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Iterative reconstruction as a novel method of radiation dose reduction at computed tomography in patients with Crohn's disease
… levels of radiation dose to patients with Crohn’s disease from medical imaging and the notable shift towards CT imaging making these patients an at risk group, provided context for this work. CT delivers some of the highest doses of ionising radiation in diagnostic radiology. Once a medical …
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Mass spectrometry-based protein profiling strategies for biomarker discovery in liver and inflammatory bowel diseases
… and applied to liver and inflammatory bowel diseases (IBDs) for the discovery of new biomarkers. The first of them, based on bulk solid-phase extraction combined with matrix-assisted laser desorption/ionization - Time of Flight mass spectrometry (MALDI-TOF MS) and chemometric analysis of …
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Markers and outcome measures in chronic immune mediated artrhritis: from association studies to prediction models.
… Three association studies of carriage of Crohn’s disease associated CARD15 polymorphisms are shown. We first investigated the association between carriage of CARD15 polymorphisms and SpA related symptoms in Crohn’s disease. Inversely, the association between gut inflammation in SpA and …
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Geographic Differences in the Risk of Surgery in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
Crohn’s disease (CD) and ulcerative colitis (UC), collectively known as the inflammatory bowel diseases (IBD), are chronic immune mediated conditions. The pathophysiology of these disease is not well understood but genetic predisposition, dietary and microbiome-related factors, and environment …
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Visualization and quantification of autophagy in primary gastrointestinal epithelia cell cultures.
… protein Atg16L1, and NOD2 as risk alleles for Crohn’s disease. Atg16L1 is essential for the formation of autophagosomes and autophagosome formation is stimulated following recognition of bacterial cell wall peptide muramyl dipeptide (MDP) by NOD2. Crohn’s disease results from an autoimmune …
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