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Showing 1 to 20 of 20 for “"Crohn's disease (CD)"”.
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Predicting poor outcome Crohn's disease at the time of first diagnosis
Over time, the majority of patients with Crohn's disease (CD) will develop irreversible gastrointestinal (GIT) damage, notably strictures or fistulas, impacting negatively on quality of life and resulting in hospitilisation and surgery. Early and aggressive drug therapy with immunomodulators (IMMs) …
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Interplay between Cannabinoids, SOCS3, and Autophagy Process in the Intestinal Epithelium with the Use of an Established in vitro Model System.
… degradation pathway. Emerging data associates Crohn's Disease (CD) with an impaired ATG16L1 autophagy gene. Increased activity in the endocannabinoid system and up-regulation of suppressor of cytokine signalling (SOCS)-3 protein expression are evident in inflamed intestine. We accessed the …
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Complex Evaluation of the Effectiveness of Biological Therapy in Patients with Active Ulcerative Colitis // Комплексна оценка на ефективността от биологична терапия при болни с активен язвен колит
Inflammatory bowel diseases (IBD), namely ulcerative colitis (UC) and Crohn's disease (CD), are chronic immune-mediated conditions with a high incidence in developed countries and a rapidly increasing incidence in highly industrialized countries. The pathogenesis of UC is complex and still unclear. …
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DNA alkylation repair deficient mice are susceptible to chemically induced Inflammatory Bowel Disease
The two most common forms of inflammatory bowel disease (IBD) are ulcerative colitis (UC) and Crohn's Disease (CD), which affect more than 1 million Americans. Recently the incidence of IBD has been rising in Japan, Europe and North America.' Colorectal cancer is a very serious complication of IBD, …
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The Role of Transforming Growth Factor Beta Signaling in Inflammation-Dependent Colon Cancer
Chronic inflammatory conditions such as Crohn's disease (CD) and Ulcerative colitis (UC) are risk factors for colon cancer. TGFβ has been shown to be dysregulated in colon cancer. Bacteria-induced inflammation is necessary for the induction of colon cancer in TGFβ mouse models. However, the …
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Efeito do consumo de iogurte caprino probiótico no perfil bioquímico e histopatológico de ratos
… compounds and flavonoids. Inflammatory Bowel Disease (IBD) comprises Crohn's disease (CD) and Ulcerative Colitis (UC) which refers to a chronic disease of the digestive tract, characterized by recurrent, spontaneous chronic inflammation. The UC affects the mucosa and submucosa of the colon and …
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Applications of LC-MS metabolomic profiling in inflammatory bowel disease and the development of derivatisation methods to enhance selective detection of certain compound classes
Inflammatory bowel disease (IBD) is a chronic inflammation of all parts of the gastrointestinal tract and is represented by two major variations, ulcerative colitis (UC) and Crohn's disease (CD). It is diagnosed based on the pattern of inflammation. In order to understand the pathology of the …
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The incidence of tuberculosis in the inflammatory bowel disease registry in Cape Town, South Africa
… risk of tuberculosis (TB) in inflammatory bowel disease (IBD) patients using immunosuppressive therapy (IST) is higher than the background population in developed countries. Corresponding data in areas of high endemicity like South Africa (SA) is limited. Our objectives were to calculate the …
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Molecular Typing Of Mycobacterial Isolates Cultured From The Tissue Of Inflammatory Bowel Disease (Crohn's Disease) Patients
… etiology and pathogenesis of inflammatory bowel disease (IBD) including Crohn's Disease (CD), has been investigated. The fastidious characteristics and cross reactivity of MAP with other members in Mycobacteria have produced significant challenges in their detection and identification. In this …
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Therapeutic drug monitoring of anti-TNF biologics in patients with Crohn's disease at Groote Schuur Hospital, Cape Town, South Africa
… the management of Inflammatory Bowel Disease (IBD) and have proved highly effective in both inducing and maintaining remission in both ulcerative colitis (UC) and Crohn's disease (CD). The advent of Therapeutic Drug monitoring (TDM) in recent years has allowed further optimisation of …
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Evaluation of Intestinal Microbial Diversity and a New Antibiotic Regimen in Crohn's Disease Patients
<p>Crohn's disease (CD) is a chronic granulomatous inflammatory bowel disease involving Mycobacterium avium subspecies paratuberculosis (MAP). Other microorganisms such as adherent-invasive Escherichia coli (AIEC) have also been proposed in CD association. To date, only one study investigated both …
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Real Time RT-PCR for Direct Detection of Viable Mycobacterium Avium Subspecies paratuberculosis in Chron's Disease Patients and Association of Map Infection with Downregulation in Interferon-Gamma Receptor (INFG1) Gene in Crohn's Disease Patients
… avium subspecies paratuberculosis (MAP) with Crohn's disease (CD) and not with ulcerative colitis (UC), two forms of inflammatory bowel disease (IBD), has been vigorously debated in recent years. This theory has been strengthened by recent culture of MAP from breast milk, intestinal tissue and …
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Possible Use Of P20 Antigen In Serodiagnosis Of Inflammatory Bowel Disease
Crohn's disease (CD) is an idiopathic, chronic, relapsing inflammatory disorder, which is most commonly involved terminal ileum and colon. The incidence and prevalence of CD has dramatically increased during the last 50 years; however, the etiology and mechanism of this disorder remain unveiled. …
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Establishment of a Long Term Cell Culture Model for Testing Anti-Infectives against Mycobacterium avium subsp. paratuberculosis
… bacterium that is the causative agent of Johne's disease (JD) in ruminants and has long been suggested to be associated with complications of Crohn's disease (CD) in humans. Although there is no direct evidence that MAP is the primary etiological agent for CD, most CD patients are found to have …
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Unravelling the role of microbiome and Escherichia coli as a trigger for Inflammatory Bowel Disease with a particular focus on Crohn's disease.
Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the digestive tract consisting of two primary forms: Crohn's disease (CD) and ulcerative colitis (UC). The pathogenesis of IBD is still not precisely known. However, an imbalance in the intestinal microbiome (dysbiosis) and …
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Unravelling the role of microbiome and Escherichia coli as a trigger for Inflammatory Bowel Disease with a particular focus on Crohn's disease.
Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the digestive tract consisting of two primary forms: Crohn's disease (CD) and ulcerative colitis (UC). The pathogenesis of IBD is still not precisely known. However, an imbalance in the intestinal microbiome (dysbiosis) and …
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Metabolomic modelling and applications in inflammatory bowel diseases
… methods to generate metabolic fingerprints. Crohn's Disease (CD) and ulcerative colitis (UC) are major components of Inflammatory Bowel Disease (IBD), a multifactorial disorder most likely resulting from altered immune response to commensal or pathogenic gut microbes under the influence of …
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Phenotypic characterisation of wild type and mutant strains of adherent invasive Escherichia coli and Shigella, in vitro, ex vivo and in vivo models
Crohn's disease (CD) is an inflammatory bowel disease (IBD) that is largely the result of aberrant immune responses, such as the increased production of proinflammatory cytokines including IL-1, TNF-ɑ, IFN- ɣ to microbial infections in genetically susceptible individuals.;Adherent-invasive …
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Cellular Immune Response And Gene Expression Profiling In Crohn's Dise
Despite the chronic debate in the etiology of crohn's disease (cd), a debilitating inflammatory bowel disease (ibd) closely related to ulcerative colitis (uc), an emerging interest in a possible mycobacterial role has been marked. Granuloma and pathologic manifestations in cd resemble aspects found …