Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Crohn's disease"”.
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Evolution of Surgery Risk in Crohn's Disease
While many individuals with Crohn’s disease require surgery for management, the risks of surgery are not well characterized in population-based studies. Advances in medical management may have influenced the risk of surgery over time. However, studies have not adequately evaluated the effect of …
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Towards a translational understanding of colonic bacteria in Crohn's disease pathology
Crohn’s disease (CD) is a chronic inflammatory condition of unknown aetiology, with the microbiota thought to be a major contributor to the disease. This thesis aimed to investigate the potential role of the gut microbiota in this context. The approaches taken were to examine CD associated …
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Iterative reconstruction as a novel method of radiation dose reduction at computed tomography in patients with Crohn's disease
… levels of radiation dose to patients with Crohn’s disease from medical imaging and the notable shift towards CT imaging making these patients an at risk group, provided context for this work. CT delivers some of the highest doses of ionising radiation in diagnostic radiology. Once a medical …
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A Geographical Exploration of Inflammatory Bowel Disease
A chronic disease that afflicts 200 000 Canadians of all ages, inflammatory bowel disease has no known cure or aetiology. Using socioeconomic Census variables, population-level models of inflammatory bowel diseases – Crohn's disease and ulcerative colitis – were made for two large cities in Alberta …
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Symptom burden in individuals with inflammatory bowel disease: a mixed methods study
… of individuals with inflammatory bowel disease (IBD). An explanatory sequential mixed methods study was conducted. A cross-sectional, correlational survey was first undertaken. Symptom burden was measured using a modified disease specific version of the Memorial Symptom Assessment Scale, …
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Investigation of the TNF superfamily of ligands as potential therapeutic targets in inflammatory bowel diseases
Inflammatory bowel diseases (IBD) are chronic diseases of the gut affecting a significant proportion of the population in the western world with increasing incidence globally. They are multifactorial diseases with susceptibility mediated by a combination of host genetics and environmental factors …
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Investigating the host-microbe dialogue in aging
… in the context of aging and life stage related diseases. The focus was maintained on key inter-kingdom signalling molecules, host produced but bacterially modified Bile acids (BAs) and on dietary microbially derived Fatty acids (FAs) as key elements to indicate gut microbial potential impactful …
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Towards a cognitive neurobiology of brain-gut axis disorders
… bowel syndrome (IBS) and inflammatory bowel disease (IBD). Despite a growing understanding of the neurobiology of brain-gut axis dysfunction, there is a relative paucity of investigations into how the various factors involved in dysregulating the brain-gut axis, including stress, immune …