Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Crohn's"”.
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Evolution of Surgery Risk in Crohn's Disease
While many individuals with Crohn’s disease require surgery for management, the risks of surgery are not well characterized in population-based studies. Advances in medical management may have influenced the risk of surgery over time. However, studies have not adequately evaluated the effect of …
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Towards a translational understanding of colonic bacteria in Crohn's disease pathology
Crohn’s disease (CD) is a chronic inflammatory condition of unknown aetiology, with the microbiota thought to be a major contributor to the disease. This thesis aimed to investigate the potential role of the gut microbiota in this context. The approaches taken were to examine CD associated …
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Iterative reconstruction as a novel method of radiation dose reduction at computed tomography in patients with Crohn's disease
… levels of radiation dose to patients with Crohn’s disease from medical imaging and the notable shift towards CT imaging making these patients an at risk group, provided context for this work. CT delivers some of the highest doses of ionising radiation in diagnostic radiology. Once a medical …
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A Geographical Exploration of Inflammatory Bowel Disease
… models of inflammatory bowel diseases – Crohn's disease and ulcerative colitis – were made for two large cities in Alberta as well as for the entire province. For modelling, a rule was made to link the imperfectly overlapping dissemination areas (a census unit in which patient data were …
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Investigation of the TNF superfamily of ligands as potential therapeutic targets in inflammatory bowel diseases
… the gut microbiota. There are two major forms - Crohn's disease (CD) and Ulcerative colitis (UC) differing in their location along the gastrointestinal tract, their pathophysiology, and characteristics of the ongoing innate and adaptive immune responses. While CD is largely characterised by a …
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Symptom burden in individuals with inflammatory bowel disease: a mixed methods study
To investigate the symptom burden experiences of individuals with inflammatory bowel disease (IBD). An explanatory sequential mixed methods study was conducted. A cross-sectional, correlational survey was first undertaken. Symptom burden was measured using a modified disease specific version of the …
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Disruption of Immunoregulatory Functions of Intestinal Mesenchymal Stromal Cells and their Progenitors in Inflammatory Bowel Disease
Crohn’s Disease (CD) and Ulcerative Colitis (UC), the two major forms of Inflammatory Bowel Disease (IBD), are multifactorial autoimmune diseases caused by an abnormal immune response to gut microbiota in genetically susceptible individuals resulting in dysregulation of type 1/2/17 immune …
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Investigating the host-microbe dialogue in aging
This thesis aimed to investigate the role of the gut microbiota and their associated functionality in the context of aging and life stage related diseases. The focus was maintained on key inter-kingdom signalling molecules, host produced but bacterially modified Bile acids (BAs) and on dietary …
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Towards a cognitive neurobiology of brain-gut axis disorders
… within this population was that patients with Crohn’s disease exhibit impaired selective attention/ response inhibition on the classic Stroop interference test. These cognitive deficits may serve to perpetuate and sustain brain-gut axis dysfunction. Furthermore, this research has shed light on …