Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Crk"”.
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A Role for RAS in V-CRK Transformation
<p>The v-Crk oncogene product, while possessing no intrinsic tyrosine kinase activity, causes an elevation in levels of cellular phosphotyrosine as it transforms chicken embryo fibroblasts (CEF). Because of this similarity to v-Src transformation and EGF receptor (EGFR) stimulation, signalling …
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The role of adaptor proteins Crk and CrkL in lens development
… have not been identified. Adaptor proteins Crk and CrkL are SH2- and SH3-containing proteins that transduce signals from upstream tyrosine phosphorylated proteins to downstream effectors, including Ras, Rac1 and Rap1, which are important for cell proliferation, adhesion and migration. …
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Molecular Cloning of Avian Sarcoma Virus CT10 and Characterization of its Protein Product
… of 47 kilodaltons, termed p47<sup>gag-crk</sup>. This protein contains blocks of sequence similarity to a noncatalytic, potentially regulatory region found in the nonreceptor tyrosine kinases, a phosphoinositide-specific phospholipase C, and the ras GTPase activator protein; no homology …
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Propagation of Juvenile Freshwater Mussels (Bivalvia: Unionidae) and Assessment of Habitat Suitability for Restoration of Mussels in the Clinch River, Virginia
… from Blackford, Clinch River Kilometer (CRK) 478 to the Tennessee border, CRK 325. Physical characteristics identified in the survey were combined with water quality and impact source data to develop a habitat suitability index for freshwater mussels within this study reach. Model …
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Exploring the Biophysical Properties of Domains Within Multi-Domain Proteins
… The Src homology 3 (SH3) domain from the c-Crk-I adaptor protein has been labeled with a Trp analogue, 7- zatryptophan (7AW), using E.coli Trp auxotrophs. Biophysical analysis shows that incorporation of 7AW does not significantly perturb the structure or function of the isolated domain. …
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Identification of genetic and epigenetic alterations in workers exposed to benzene [Identificazione di alterazioni genetiche ed epigenetiche in lavoratori esposti a benzene]
… monitoraggio ambientale. Nove geni chiave (CRK, CXCR6, GSPT1, KPNA1, MECP2, MELTF, NFKB1, TBC1D7 e ZNF331) erano costantemente sovraregolati nei lavoratori esposti al benzene, evidenziando il loro potenziale ruolo come indicatori molecolari di esposizione. Le analisi delle curve ROC hanno …
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New experimental and theoretical tools for studying protein systems with elements of structural disorder
… protein-peptide encounter complex study based on Crk-Sos model system. The ten-residue Sos peptide serves as a minimal model for disordered proteins. Encounter complex is an important type of intermediate state formed during many protein interactions. Such complexes are usually characterized by a …
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Molecular Mechanisms Of Pressure-Stimulated Cancer Cell Signaling
… 118 form a docking site for the adaptor molecule Crk, which has a binding site for the highly phosphorylated molecule Cas. Each member of the paxillin/Crk/Cas complex is necessary for pressure stimulated adhesion. Furthermore, this complex promotes the activation of the small GTPase, Rac1. </p> …
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Context-Aware Resource Management
The demand for performance and resources that is placed on the system is dictated by the application alone in non-interactive environments, and by a combination of application and user interactions in interactive environments. Understanding user interaction can provide valuable information about …
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Analysis of cyclin dependent kinases in Leishmania
… Leishmania major. Cdks in kinetoplastids, CRKs, are the key regulators that allow cells to progress through different cell cycle phases and promote parasite proliferation during infection. In chapter 3 of this study, the results presented showed that L. major CYCA is capable of activating …
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Identifikation von Signalweginteraktionspartnern des Zelladhäsionsmoleküls Muc18/MCAM/CD146
… Proteine wurden als das Adapterprotein p130Cas (crk-associated substrate) und sein Ligand p105CasL identifiziert. Eine Muc18-assoziierte Phosphorylierung von fak („focal adhesion kinase“) und fyn (eine Proteintyrosinkinase der src-Familie) wurde nicht beobachtet. P130Cas und p105CasL, sowie nck, …
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Studies of the Mechanisms of Reverse Signaling by CD40L
… SH2-domain binding array identified Abl2, CRK, and CRKL as candidates that interact with the highly conserved phosphorylated tyrosine residue at position 5 (Y5) in the CD40L cytoplasmic domain. To assess structural requirements, CD40L constructs with either a cytoplasmic domain deletion or …
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The C. trachomatis effector protein TepP hijacks host cell signaling pathways to promote bacterial survival during infection.
… determined that TepP interacts with the Crk family of host cell adaptor proteins, and the class 1 phosphoinositol-3-kinase (PI3K). Cell lines where the levels or activity of TepP interacting partners were modified by deletion, knockdown, or inhibitors, showed that these host proteins are …
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Protein-Protein Interactions and Muscle cell Signaling Via Syntrophin
… slightly higher affinity than Grb2-N-SH3 domain. Crk-L, an SH2/SH3 protein of similar domain structure but different specificity does not bind these s yntrophin sequences.</p> <p>Dystrophin glycoprotein complex has been proposed to be involved in signal transduction. We have shown that laminin …
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Die Hämatopoetische Progenitor Kinase (HPK) 1 und NFAT-Transkriptionsfaktoren unterstützen die Apoptose von T-Lymphozyten
… T-Zellen (LAT) und den Adaptorproteinen Nck, Crk, Gads, Grb2, Grap, CrkL sowie SLP-76 gezeigt. Für die Aktivierung der nach TZR-Stimulation in den Lipid-Rafts lokalisierten HPK1 sind sowohl Lck als auch ZAP-70 notwendig [Liou et al., 2000; Liu et al., 2000a; Ling et al., 2001]. Diese Daten …