Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Critical windows"”.
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Defining critical windows in pituitary development and elucidating sex differences in response to bisphenoL A
Open Restriction set for Item 102628 on 2019-06-12T18:33:51Z with date null by mhoh2@illinois.edu.
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Immunotoxicological Evaluation Of Critical Windows Of Development Following Exposure to 1,2:5,6 Dibenzanthracene in B6C3F1 Mice
Numerous findings have suggested that the increased prevalence of childhood illnesses such as cancer, infection, and allergy may be due to environmental exposures. One such cause may be maternal smoking or passive smoke exposure. Known immunotoxicants in cigarette smoke and environmental pollution …
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Unravelling the impact of early-life nutrition on microbiota-gut-brain axis signalling
… in the gut microbiota composition during critical periods of development perinatally might influence the developmental trajectory of the brain and the immune system, with implications for their function later in life. Although the effects of diet-induced microbiota alterations have been …
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Bayesian treed distributed lag models
… exposure-time-response function and identifying critical windows during which exposures can alter a health endpoint. In this dissertation, we develop novel formulations of Bayesian additive regression trees that allow for estimating a DLM. First, we propose treed distributed lag nonlinear models …
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The Effects of Neuroendocrine Stress on Larval Development
… across all stages of their life cycles. Critical windows of development, common in young and developing animals, are time periods when stressors have an outsized effect and can permanently alter phenotype. Larval amphibians use a critical window in late larval development wherein …
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Estrogenic and androgenic endocrine disrupting activity and risk assessment of phytoestrogens in Kenyan soya-based weaning flours
… (EDCs). Infants and young children have critical windows of sensitivity to EDCs during their development. Positive health effect of PEs are many such as being anti-cancer, antiobesity, promotes bone formation and wound healing. The negative health effects reported include increased …
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APPLICATION OF COMPLEMENTARY METHODS BEYOND STANDARD PATHOLOGY TO INVESTIGATE KETAMINE NEUROTOXICITY IN MODELS OF PEDIATRIC ANESTHESIA
… growing evidence suggests that exposure during critical windows of brain development may induce neurotoxicity. This thesis aimed to preclinically characterize ketamine-induced neurotoxicity in the rat neonatal brain, elucidate the affected cell populations and mechanisms, and refine both in vivo …
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Microbiota-gut-immune-brain communication across the lifespan
… results provide novel insights on time sensitive critical windows for the gut microbiome, and its impact in behaviour and immunity outcomes in the host. While further investigation into the mechanisms underlying these effects is crucial, these findings highlight the involvement of gut microbial …
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Early life exposure to metals and adolescent neurodevelopment
… to the understanding of metal neurotoxicity in critical windows of development and in relation to less studied neurodevelopmental domains, like motor function.
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Prenatal stress, the placenta and maternal microbial transmission; implications for health and disease
… to stress-induced maternal cortisol during critical windows of development increases the risk of adverse outcomes in the offspring. At the core of this hypothesis is the placenta, which expresses the enzyme 11beta hydroxysteroid dehydrogenase type 2 (HSD11B2), which ultimately controls the …