Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Critical size defect"”.
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Characterization of the early stages of long bone regeneration in fractures and critical size defects in Xenopus Laevis
… injuries or cancer irradiation can cause critical sized defects in long bones. Regeneration capabilities of most mammals in their long bones are robust in small defects such as fractures but diminish in large defects due to lack of proper cellular cues. A small animal in vivo model has …
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Regeneration of Peripheral Nerves Using Neuroinductive Biomaterial Scaffolds
… strategies for bridging peripheral nerve defects. The first strategy is based on a classic tissue engineering approach, and involves the use of modified acellular grafts interposed across a nerve gap. The second strategy introduces keratin made from human hair as a promising, …
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Diffusion Problems in Wound Healing and a Scattering Approach to Immune System Interactions
<p>A theoretical model for the existence of a Critical Size Defect (CSD) in certain animals is the focus of the majority of this dissertation. Adam [1] recently developed a one-dimensional model of this phenomenon, and chapters I–V address the exist the CSD in a two-dimensional model and a …
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Silver Nanoparticles As Drug Delivery Systems
… Red). Also, we will evaluate the healing of critical size mouse calvarial defects with light activated miR-148b-Nanoparticle conjugates. After testing the in vitro differentiation of hASCs, we will evaluate the healing of calvarial size defects with SNP-miR-148b. A 4 mm critical size defect …
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Shape Memory Polymers as 2D Substrates and 3D Scaffolds for the Study of Cell Mechanobiology and Tissue Engineering
… was demonstrated in a mouse segmental defect model, where expanding foams were deployed intraoperatively to fill and conform to a critical size defect. Stiff SMP foams were able to maintain defect stability in a load-bearing application and integrated with the native bone after 12 …
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Enhancing bone healing through concurrent anabolic- and anti-catabolic pharmacological treatment
… to callus resorption. In this thesis, we hypothesized that concurrent treatment with the bisphosphonate zoledronate (ZOL) could counteract this resorption, leading to superior healing compared to isolated BMP-7 treatment. In studies 1, 2 and 3, the synergistic effect of BMP-7 and zoledronate was …
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Driving tissue morphogenetic cascades using tunable nanolayered surface coatings
… implants, the functional success of an implant critically depends on its stable interaction and bonding with the host tissue. Yet, aseptic implant loosening accounts for over half of all joint replacement failures. Non-biological implant materials such as metals and plastics are used for their …
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Multi-scale characterization of swine femoral cortical bone and long bone defect repair by regeneration
… of age and regeneration of bone in long bone critical sized defects. In the first part of this study, a multi-scale experimental work was carried out to characterize cortical bone as a heterogeneous material with hierarchical structure. We analyzed bone at several different length scales: …