Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Critical Size"”.
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Preclinical Evaluation of 3D Printed Biomaterials for Repairing Critical-Size Bone Defects
… graft substitute to support bone healing for critical size (non-healing) bone defects and can be customised to patients’ specific needs. Research Methodology: The work in this thesis extends across five fundamental sections: <br>1- Isolation and characterisation of adipose-derived mesenchymal …
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Critical size for bulk-to-discrete transition and segment-induced size effect melting of 2D aliphatic layers
Size miniaturization of aliphatic layers is of interest in the fundamental understanding of their structure-property-relationship. This research studies the size-dependence of structure evolution and thermodynamic principles in a model system of silver alkanethiolate (AgSCn), which consists of …
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Characterization of the early stages of long bone regeneration in fractures and critical size defects in Xenopus Laevis
… injuries or cancer irradiation can cause critical sized defects in long bones. Regeneration capabilities of most mammals in their long bones are robust in small defects such as fractures but diminish in large defects due to lack of proper cellular cues. A small animal in vivo model has …
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A further study of the incubation period of the age-hardening of aluminum-copper alloys
… in forming the equilibrium concentration of critical size embryos which must be achieved before steady state nucleation can proceed. This rate of diffusion is a function of the temperature, degree of supersaturation, number of critical size embryos and plastic deformation.
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Effects of aneuploidy on growth and cell cycle progression
… strains delay cell cycle entry by increasing the critical size for budding and by decreasing the rate of volume accumulation during the G 1 phase of the cell cycle. This increase in the critical size for budding is due to in a delay in CLN2 mRNA accumulation and can be suppressed by supplying …
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Towards an autologous tissue engineering construct for craniofacial bone repair
Patients with critical-size bone defects, as a result of trauma, congenital malformations or tumor resections, generally have limited healing without clinical intervention. The autograft is the current standard of care for repair of these defects due to capacity for osteointegration and …
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Consequences of the choices on the accounting methods and the payment methods for acquirers and targets : a comparative study between NYSE/Amex and NASDAQ for the nineties
… of the global economy and the research of the critical size and the optimal strategy. This thesis investigates the choice of accounting method (pooling versus purchasing) and the choice of the method of payment (cash versus stock) for mergers in the 90's. We identify significant differences in …
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Multi-scale characterization of swine femoral cortical bone and long bone defect repair by regeneration
… of age and regeneration of bone in long bone critical sized defects. In the first part of this study, a multi-scale experimental work was carried out to characterize cortical bone as a heterogeneous material with hierarchical structure. We analyzed bone at several different length scales: …
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Silver Nanoparticles As Drug Delivery Systems
… Red). Also, we will evaluate the healing of critical size mouse calvarial defects with light activated miR-148b-Nanoparticle conjugates. After testing the in vitro differentiation of hASCs, we will evaluate the healing of calvarial size defects with SNP-miR-148b. A 4 mm critical size defect …
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Disordering of small metal particles in a scanning transmission electron microscope
… diffraction spots. Only particles below a critical size are seen to fully disorder. We have observed this disordering in Platinum, Palladium, Rhodium, and Iridium and have developed a model for the disordering process. In this model, electrons scattering from surface atoms transfer enough …
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Development and evaluation of the innovative 3D printed scaffolds for bone regeneration in vitro and in vivo /
… matrix) scaffolds in the Wistar rat critical-size calvarial defect model were analysed in the study. Moreover, the obtained results were compared with one of the most well-known and widely used xenogeneic materials in clinical practice – Geistlich Bio-Oss®. This study's in vitro and …
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ADDUCINS AFFECT CORTICAL NEUROGENESIS BY REGULATING PROGENITORS¿ MORPHOLOGY AND FATE
… neocortex expanded massively, reaching a critical size in human. The main reason for this change can be found during neocortical development in an increased neuronal production during a prolonged neurogenic period. Neocortical development starts during embryogenesis with the main neural …
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The structure and stability of expanding and converging near-stoichiometric flames
… reactant. However, once the flame achieves a critical size, a cellular instability appears, consistent with experimental observations. The effects of viscosity and equivalence ratio on the onset of instability as well as the subsequent development of a cellular structure is studied. …
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Additive manufacturing of stiffness optimised auxetic bone scaffold using cobalt-chromium-molybdenum superalloy
… constructs, such as bone scaffolds for critical-size defects. Emerging early-stage studies have shown the potential of auxetic architecture in increasing cell proliferation and tissue reintegration due to their −𝜐. However, research on the development of stiffness optimised auxetic …
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The fracture and autogenous comminution of quartzite
… main process variables, namely rock petrography, size distribution of the feed, applied load, relative velocity and environment. In this manner the optimisation of the process and an improvement of its efficiency was sought. In addition the establishment of testing procedures to predict the …
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Electronic and Plasmonic Properties of Nano-Sized Gold/Strontium Titanate Interface
In this thesis, nano-sized metal/oxide interfaces are fabricated to determine the size dependence of electronic and resistive switching properties, effect of atomic structure on the orientation dependence of electronic properties, and mechanisms of plasmon-induced current enhancement. A combination …
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Optical properties of size selected nanocrystallites in porous silicon
… free. SEM micrographs showed that crystallite sizes in the ideal porous films are smaller than that prepared by conventional methods. Ideal porous silicon films were found to have a crystallite size gradient along the length of the sample, and appeared (under UV illumination) reddish, orangish, …
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Development of polyHIPE scaffolds for improved bone regeneration
Critical size bone defects resulting from trauma or disease are challenging to treat due to the size and shape of the defect. Autologous tissue remains the gold standard due to the superior healing potential but harvesting material is challenging due to donor site complications. We have designed a …
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DEVELOPMENT OF A TISSUE ENGINEERED SKELETAL MUSCLE REPAIR CONSTRUCT FEATURING BIOMIMETIC PHYSICAL, CHEMICAL, AND MECHANICAL CUES
… lacking. The "gold standard" for treatment of critical-size defects remains autografting, which is restricted by donor site availability and morbidity, and further is often associated with incomplete repair of function or restoration of cosmesis. In the current work, we describe an in vitro …
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Natural Polymeric Carriers for Local Delivery of Therapeutic Agents to Promote Enhanced Bone Regeneration
… to heal, but on occasion defects surpass a critical size capable of spontaneously healing. These critically-sized bone defects pose significant challenges for reforming bone continuity and often require surgical intervention to facilitate bone regeneration. Recently, products combining …
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