Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"Critical Pathways"”.
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the impact of Ape/Ref1 on hypoxia regulated genes; potential applications for cancer
… unmet medical need, a better understanding of critical pathways and molecular mechanisms involved in pancreatic tumor development, progression, and resistance to traditional therapy is therefore critical. Reduction¿oxidation (redox) signaling systems are emerging as important targets in …
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Value creation through modernizing Chinese medicine
… markets as officially approved drugs through critical pathways, both scientific and regulatory, Chinese herb drugs must demonstrate sound evidence for safety and efficacy. I address in this thesis one of the central concerns of the pharmaceutical companies and FDA, that is, how quality control …
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Trends in vegetation productivity and seasonality for Namaqualand, South Africa between 1986 and 2011: an approach combining remote sensing and repeat photography
… data set this study aimed to: (1) Determine the critical pathways of inter-annual and intra-seasonal vegetation change in the Namaqualand; (2) Investigate the role of land-use and climate variability as key drivers of vegetation change in Namaqualand.
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The Mechanism of Obesity in Rai1+/- Mice
… haploinsufficiency of Rai1 causes deviations in critical pathways responsible for energy intake and expenditure. Data suggest that the Rai1+/- mice are obese and hyperphagic. Data also demonstrate that Rai1+/- mice do not have symptoms of metabolic syndrome associated with their obesity. …
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Virus restriction gene variants and their possible role in neurocognitive function in children born to HIV-infected mothers
… but uninfected group may be a pointer to critical pathways in differential HIV susceptibility. Exposure and infection with HIV is controlled by a multitude of genes/processes, thus, SNPs are unlikely to show statistically significant effects individually and may be more useful in a …
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Adverse Childhood Experiences and Acute Coronary Syndrome in Adulthood
… (such social support and church attendance), as critical pathways that can lead to cardiac health outcomes. Further examination of religiousness and emotion regulation pathways should follow to further elucidate on the mechanisms that underlie the ACE-ACS relationship.
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Developmental signaling pathways in adult energy homeostasis
Many signaling pathways which are classically understood for their roles in early development are also known to be involved in tissue maintenance and adult energy homeostasis. Furthermore, dysfunction of these signaling pathways results in human diseases such as cancer. An in depth understanding of …
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Enhanced Recovery Pathway for Colorectal Surgery Improves Outcomes in Private and Safety-Net Settings
… Although it is known that Enhanced Recovery Pathways (ERP) decrease length of stay (LOS) and improve outcomes in colorectal surgery, these studies predominantly represent the private health care setting. There is a paucity of information regarding the effectiveness of ERP in the public arena, …
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Regulation of the development and regeneration of the zebrafish posterior lateral line
… cochlear morphology. Foxg1 interacts with many critical pathways and cellular processes of hair cell development and homeostasis. YEATS domain-containing 2 (YEATS2), functions as part of an epigenetic protein complex acting as a reader of post-translational histone modifications. As a subunit of …
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Effect of Epigallocatechin-3-gallate on a pattern separation task and hippocampal neurogenesis in a mouse model of Down syndrome
… in Ts65Dn mice, and is involved in a number of critical pathways including CNS development and osteoclastogenesis. Epigallocatechin-3-gallate (EGCG), the main polyphenol in green tea, inhibits Dyrk1a activity. We have shown that a three-week EGCG treatment (~10mg/kg/day) during adolescence …
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Coupled Air-Sea-Land Interactions: Understanding the MJO Eastward Propagation and Maritime Continent Barrier Effect
… and interannual variability. We identify some critical pathways that can help improve MJO modeling and prediction through a better representation of:Chapter 2: The multi-scale convective structure of the MJO. Chapter 3: Air-sea interaction of the MJO and its effect on the upper ocean. Chapter …
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Genetic Predictors of Clinical Outcomes In Non-Small Cell Lung Cancer Patients
… adopted pathway-based approach focusing on two critical pathways - miRNA and inflammation pathways. MicroRNAs (miRNA) post-transcriptionally regulate around 30% of human genes. Polymorphisms within miRNA processing pathways and binding sites may influence patients’ prognosis through altered gene …
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Genetic ancestry and population health: elucidating the relative role of African genetic ancestry in cancer genomics and the broader implications for racial health disparities in cancer
… genetic variation, may play a critical and underexplored role in shaping cancer risk and outcomes. This thesis investigates how ancestry-linked genetic variants may contribute to cancer development, progression, and disparities between human populations, particularly those found …
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Key roles of glutamate metabolism and cuticle permeability in the multifaceted defense response of the abscisic acid deficient sitiens tomato mutant against Botrytis cinerea
… nitrogen metabolism, the plant GM orchestrates critical defense-associated events related to nitrogen transportation, cellular redox regulation, and TCA cycle-dependent energy reprogramming. These modulations seem to eventually result in either ‘endurance’, i.e. maintaining the functionality of …