Global ETD Search
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Showing 1 to 20 of 26 for “"Creutzfeldt-Jakob"”.
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Risikofaktoren der sporadischen Creutzfeldt-Jakob-Krankheit
Die sporadische Creutzfeldt-Jakob-Krankheit (sCJK) macht den größten Anteil an den humanen Transmissiblen Spongiformen Enzephalopathien aus, ihre Ursache gibt noch immer viele Rätsel auf. In der vorliegenden Arbeit wurde eine Fall-Kontroll-Studie mit 1155 deutschen sicheren und wahrscheinlichen …
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Doxycyclin bei der sporadischen Creutzfeldt-Jakob-Krankheit
Die sporadische Creutzfeldt-Jakob-Krankheit (CJK) ist eine seltene neurodegenerative Erkrankung aus der Gruppe der Prionerkrankungen. Als zentraler pathophysiologischer Mechanismus wird die Ablagerung von pathologischem Prionprotein (PrPSc) angenommen, die zu Funktionsausfall und Zelltod im …
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Übertragung von BSE auf nicht humane Primaten als Modell für die variante Creutzfeldt-Jakob Erkrankung (vCJD) im Menschen
… Nahrungsmitteln, an der varianten Creutzfeldt-Jakob Erkrankung (vCJD) zu erkranken. Als Tiermodell für den Menschen dienen Javaneraffen (Macaca fascicularis). In der Studie wurden Gruppen von je 6 nicht humanen Primaten intracerebral oder oral mit Verdünnungsreihen aus Hirnhomogenat …
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Transthyretin-, Aß 1-40- und Aß 1-42- und Tau-Protein-Konzentrationen im Liquor cerebrospinalis bei demenziellen Erkrankungen
… Demenzerkrankungen wie Alzheimer-Demenz, Creutzfeldt-Jakob-Krankheit, Lewy-Körperchen-Demenz, frontotemporale Demenz und Normaldruckhydrozephalus im Vergleich zu einer gesunden Kontrollgruppe untersucht. Als Ergebnisse zeigten sich vor allem erniedrigte beta-Amyloidpeptid 1-42/1-40 …
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Exploring Novel Immunodiagnostics for Prion Disease
… of mammals. TSEs of global importance include Creutzfeldt-Jakob Disease (CJD) in humans, Chronic Wasting Disease (CWD) in cervids, and Bovine Spongiform Encephalopathy (BSE) in cattle. These diseases occur when the normal cellular prion protein (PrPC) misfolds, producing the infectious isoform …
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Vergleichende Analyse der Gerstmann-Straeussler-Scheinker-Syndrom-assoziierten Mutation A117V mit der neuen pathogenen Mutation G114V des humanen Prion-Proteins in vivo und in vitro
… clinical symptoms overlap with GSS as well as Creutzfeldt-Jakob disease. Due to their close vicinity within the transmembrane domain of PrP and misincorporation of valine in both cases, PrP G114V and PrP A117V were investigated in comparative studies. Both mutations caused a similar cellular …
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Using Saccharomyces cerevisiae to characterise the in vivo effects of exposure to the prion-curing drug Tacrine and the fungal metabolite gliotoxin
… neurodegenerative disorders in mammals, such as Creutzfeldt-Jakob Disease (CJD) and Bovine Spongiform Encephalopathy (BSE). Fungal prions also exist, which provide a useful tool for studying the propagation of these non-mendelian genetic elements. Possibly the most widely-studied S. cerevisiae …
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Metabolic Profiling of Prions In The Gastro-Intestinal Tract
… spongiform encephalopathy in cattle to variant Creutzfeldt-Jakob disease in humans due to consumption of contaminated meat. The most probable natural route of transmission is by oral consumption of infectious material. Even though this mode of transmission has been known for a long time it is …
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Net-PPI : mapping the human interactome with machine learned models
… life-threatening conditions, such as Alzheimer, Creutzfeldt-Jakob, and cancer; making the regulation of PPI activities a promising direction for pharmaceutical development. Despite the indisputable importance of PPIs, so far only a tiny fraction of all human PPIs has been discovered, and our …
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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT
… fatal neurodegenerative diseases that include Creutzfeldt-Jakob disease, bovine spongiform encephalopathy and sheep scrapie. TSE disease pathology and mechanisms within the central nervous system (CNS) of an infected host largely remains unclear. At the cellular level, the uptake of protease …
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Decontamination of prions, prion-associated amyloid and inefectivity from surgical stainless steel - implications for the risk of iatrogenic transmission of CJD
… variant, iatrogenic<br/>and sporadic forms of Creutzfeldt-Jakob Disease (CJD) suggests deposition of the infectious<br/>agent across a wide range of extraneural, lymphoid tissues, as well as in the skeletal muscle<br/>and blood. Coupled with the potential for asymptomatic carriers, there is a …
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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT
… fatal neurodegenerative diseases that include Creutzfeldt-Jakob disease, bovine spongiform encephalopathy and sheep scrapie. TSE disease pathology and mechanisms within the central nervous system (CNS) of an infected host largely remains unclear. At the cellular level, the uptake of protease …
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Preparation, characterisation and transcriptome analysis of RNA frm human vCJD brains.
The pathological mechanisms of variant Creutzfeldt-Jakob disease (vCJD) in the human brain remain poorly understood. Gene expression data may provide insight into the molecular mechanisms involved. This requires analysis of human postmortem brain tissue however; the variability in RNA preparations …
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Modelli murini transgenici di malattie da prioni per lo studio del ruolo fisiopatologico della proteina prionica.
… represented by fatal familial insomnia (FFI) and Creutzfeldt-Jakob disease (CJD178), two clinically and neuropathologically distinct diseases linked to the D178N mutation in the gene encoding PrP; D178N/M129 segregates with FFI, while D178N/V129 is associated with CJD. We have engineered …
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Blood safety and resource allocation: economic analyses of donated blood safety initiatives
… travel due to possible exposure to variant Creutzfeldt-Jakob disease. Expanded European travel deferral will lead to the permanent deferral of 3,271 donors (95% Confidence Range, 2,600--3,973 donors) reducing the supply of blood by 3,141 units out of an approximate 94,000 unit annual supply …
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The role of germline and somatic nuclear and mitochondrial DNA variation in neurodegenerative disorders
… novel copy-number gain in LAMA5 associated with Creutzfeldt-Jakob disease (CJD), and fourthly, we determine that at least 1% of the population carry high level somatic protein-coding mutations affecting at least 10% of cells within the brain. Subsequently, additional focussed deep-sequencing …
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STUDIO DEL RUOLO DELLA PROTEINA PRIONICA NELLA REGOLAZIONE DEL SONNO MEDIANTE L'UTILIZZO DI MODELLI MURINI TRANSGENICI
Introduction: an inherited form of Creutzfeldt-Jakob disease (CJD) is linked to the D178N/V129 mutation in the prion protein (PrP) gene. CJD is usually characterized by motor disorders, cognitive impairment and electroencephalographic alterations but recently sleep modification have been described. …
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Hybrid Particle-Nonwoven Membrane Materials for Bioseparations
… increased threat of blood-transfusion of variant Creutzfeldt-Jakob disease. This work characterizes the transport and binding properties of a novel hybrid particle-nonwoven membrane medium in which a polymeric chromatographic resin is entrapped between layers of a nonwoven polypropylene membrane …
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Identification of gene expression changes in Drosophila models of mammalian prion diseases
… spongiform encephalopathy in cattle and variant Creutzfeldt-Jakob disease in humans. Genetic prion diseases also occur in humans, which are associated with mutations in the prion protein (PrP) gene, such as genetic CJD (gCJD) and fatal familial insomnia. Prion diseases are caused by the …
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