Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"CpG-ODN"”.
-
Immunostimulatory effects and delivery of oligodeoxynucleotides containing CpG motifs (CpG-ODN) in neonatal broiler chickens
Oligodeoxynucleotides containing CpG motifs (CpG-ODN) have been shown to stimulate the innate immune system against a variety of bacterial, viral, and protozoan infections in a variety of vertebrate species. The objectives of this study were to investigate the immunostimulatory effect of CpG-ODN …
-
Die Rolle von bakteriellen DNA-Sequenzen (CpG) bei der Immuntherapie von retroviralen Infektionen
… Einsatz von immunstimulativer DNA mit CpG-Motiv (CpG-ODN) bei einer akuten Virusinfektion beschrieben. Als experimentelles Modell wurde das Friend Virus (FV), ein muriner Retroviruskomplex, verwendet. Das FV kann in Mäusen eine tödlich verlaufende Erythroleukämie induzieren. Durch die …
-
LOCOREGIONAL DELIVERY OF UNMETHYLATED CPG-OLIGODEOXYNUCLEOTIDES TO CANCER THERAPY: PRECLINICAL STUDIES
… therefore repeated intraperitoneal injections of CpG-ODN recruiting and activating innate effector cells throughout the abdominal cavity to the tumor site might control tumor cell growth and ascites formation. After a single CpG-ODN treatment, in IGROV-1 ovarian tumor ascites-bearing athymic mice, …
-
CpG-Oligonukleotid-basierte Immuntherapie von experimentellen Kolontumoren
… Wie bakterielle DNA werden dieser nachempfundene CpG-Oligonukleotide (CpG-ODN) vom Immunsystem als fremd erkannt und dienen antigenpräsentierenden Zellen als Gefahrensignal. In dieser Arbeit wurde an einem murinen Modell des Kolonkarzinoms die therapeutische Wirksamkeit von CpG-ODN getestet und …
-
Investigation of the immunostimulatory activity and vaccine potential of lipid encapsulated plasmid DNA and oligodeoxynucleoties
… and cytosine-guanine oligodeoxynucleotides (CpG-ODN; LN CpG-ODN), and examining their ability to act together as a non-viral DNA vaccine in attempt to address the shortcomings of current DNA vaccine approaches. One focus of this thesis concerns investigating the immunostimulatory activity of …
-
Incorporation of CpG Oligodeoxynucleotides into α2-Macroglobulin: Development of a Novel Vaccine Adjuvant Delivery Mechanism
… responsible for this activity are unmethylated CpG dinucleotides. Following cellular uptake, CpG-containing oligodeoxynucleotides (CpG ODN) are trafficked to the endosome where they bind Toll-like receptor 9 (TLR9) to initiate a signaling cascade that culminates in the release of numerous …
-
Immunostimulatory properties and mechanisms of action of encapsulated methylated cpg oligodeoxynucleotides
Immunostimulatory oligodeoxynucleotides (ODN) containing unmethylated CpG motifs are powerful stimulators of innate as well as adaptive immune responses, exerting their activity through the triggering of the endosomally localized TLR9 by a poorly understood mechanism. The immunopotency and broad …
-
Investigating toll-like receptor agonists as an immunotherapeutic for metastatic osteosarcoma
… receptor agonists (Pam3CSK4, Poly(I:C), and CpG ODN 2395) that fit our requirements for immune stimulation while minimizing osteosarcoma tumorigenesis. Chapter III investigates the ability of these 3 agonists to reduce osteosarcoma metastatic lung tumor burden in a clinically-relevant murine …
-
Modulation of Immune Responses Induced by Vaccination Against Bovine Respiratory Syncytial Virus
… vaccines with a Th1 promoting adjuvant, such as CpG oligoeoxynucleotides (ODN), would result in the induction of protective immunity against RSV without risk of deleterious effects. We observed in calves that parenterally delivered FI-bovine RSV (BRSV) formulated with CpG ODN resulted in a shift …
-
IMPAIRMENT OF TOLL-LIKE RECEPTOR 9 AGONIST ANTI-TUMOR ACTIVITY BY ANTI-PD-1 ANTIBODY: ROLE OF MACROPHAGES
… della co-terapia. Metodi: Un agonista del TLR9 (CpG-ODN) e un anticorpo anti-PD-1 sono stati somministrati, singolarmente o in combinazione, a topi atimici xenotrapiantati intraperitonealmente con cellule IGROV-1 del carcinoma ovarico umano. I macrofagi sono stati depletati in vivo mediante …
-
Strategies for the induction of mucosal immunity against hepatitis B virus.
… effect of unmethylated immunostimulatory CpG motifs present in the DNA backbone. Synthetic oligodeoxynucleotides (ODN) containing immunostimulatory CpG motifs (CpG) are potent adjuvants for induction of Th1-like systemic immune responses against parenterally-delivered proteins. Herein, the …
-
Intranasal Hpv Peptide Vaccine Formulation Induces Potent Cytotoxic Cd8 T Cell Immunity For The Treatment of Genital Hpv Tumors
… the combination of TLR9 and NKT cell ligands, (CpG-ODN and α-GalCer, respectively) will induce potent systemic and mucosal antigen-specific CD8 T cell response, specifically at the female reproductive tract (FRT) to eliminate HPV genital tumors.</p> <p>Utilizing an orthotopic vaginal tumor model …
-
DEVELOPING STRATEGIES TO CONTROL NECROTIC ENTERITIS IN BROILER CHICKENS
… phosphorothioate guanine oligodeoxynucleotides (CpG-ODN) by the in ovo route at day 18 of incubation, and with or without administration of a booster vaccine was able to protect birds against homologous and heterologous CP associated NE in broiler chickens. Immunoprotection against NE in broiler …
-
Investigating couplet strategies incorporating 4 pillars of cancer therapy
… radiotherapy in combination with a TLR9 agonist (CpG ODN 2395), an innate immune system stimulant, in the context of canine osteosarcoma. Here we aim to elicit radiation-induced immunogenic cell death and induce an in situ vaccine effect by administering CpG ODN 2395 intratumorally. The resultant …
-
Die Rolle von Entzündungsreaktionen bei Immunreaktionen gegen gesundes und malignes Gewebe : Etablierung eines autochthonen Tumormodells
… in der Leber, induziert durch CpG-haltige Oligodeoxynukleotide, ausreicht, um aktivierten Kb-spezifischen T-Zellen Angriff auf Hepatozyten zu ermöglichen. Kreuzreaktivität mit bakteriellen Epitopen (molekulare Mimikry) konnte damit ausgeschlossen werden. IL-12 spielt beim …
-
The pivotal role of dendritic cells in feline immunodeficiency virus infection
… cytosine-phosphate guanosine dinucleotides (CpG ODN) as adjuvant might induce protection against subsequent virulent FIV challenge. This autologous feline DC/FIV immunization did not protect recipient cats from FIV challenge. No differences were detected in FIV proviral loads, CD4+ T cell …
-
Impact Of Cryoablation On Tumor Immunity
… and/or 100 micrograms peritumoral (p.t.) CpG ODN. NeuT mice received vaccination with plasmid DNA encoding neu/Her2 and GM-CSF to induce an initial response. Specific IgG antibody (Ab) subclasses and T-cell responses were assessed using flow cytometry and IFN gamma ELISPOT assays …
-
Studies on the Interaction between Porcine Plasmacytoid Dendritic Cells and Porcine Reproductive and Respiratory Syndrome Virus
… gastroenteritis virus (TGEV) or to type A CpG-ODN, followed by a maturational change in the appearance of these cells from plasmacytoid to dendritic cell morphology. Based on their established phenotype, electronic gating on flow cytometric histograms in conjunction with multiple antibody …
-
Utilización de la proteína multicomponente Quimera de Leishmania infantum en inmunoprofilaxis y diagnóstico de leishmaniosis canina
… vía subcutánea con una dosis de PQ en adyuvante CpG/ODN, AlOH y QuilA, respectivamente. Igualmente se utilizó un grupo control de Adyuvante (Grupo A¿). Todos estos últimos grupos formaron parte del ENSAYO 2 referido al efecto de dosis, vías y adyuvantes sobre la respuesta inmune humoral frente a …