Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"CpG-DNA"”.
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Dendritic cell maturation and activation via RNA/DNA danger signals : co-delivery of protein antigen with siRNA or CpG DNA
… protein antigen and to co-deliver it with DNA/RNA-based adjuvants to dendritic cells, the key antigen presenting cells in primary immune responses. Using CpG oligonucleotides or siRNA as adjuvants, we observed via enzyme-linked immunosorbent assays for interleukin 12 and interferon-[alpha], …
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Equine innate and adaptive immunity to viral infections
… bacterial and viral cytosine-phosphate-guanine DNA (CpG-DNA). West Nile virus (WNV) infection may result in meningitis and encephalitis in humans and horses, especially aged and immunocompromised individuals. Using flow cytometric analyses and quantitative reverse transcriptase-polymerase chain …
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The effects of topical calcipotriol treatment on immune responses to vaccination
… potent Th1 inducing TLR9 agonist unmethylated CpG DNA. The effects of calcipotriol on the humoral response are subtler as we observe marginally increased production of antigen-specific IgG1 immunoglobulins along with a strong suppression of the IgG2a isotype. This is in contrast to pretreatment …
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Effetto dell’etanolo sullo stato di metilazione del gene che codifica per la neurotrofina “Brain-Derived Neurotrophic Factor”
… work was to evaluate the effects of ethanol on CpG islands of BDNF exon IX gene in regulating its expression, both “in vivo” and “in vitro”. Rat cerebellar granule cells in culture were exposed to acute ethanol, chronic ethanol or ethanol withdrawal. Our results demonstrate that ethanol exposure …
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Methylation Change of Histone H3 and CpG Sites at the TIM-3 Gene Promoter in Response to Stimulation
… 사용하여 TIM-3 promoter에서의 epigenetic 변형을 분석하였다. 먼저 DNA methyltransferase inhibitor인 5-Azacytidine을 Jurkat T 세포에 처리하였을 때 TIM-3 발현이 증가하였다. 또한 TIM-3 promoter (-1500 ~ -1)에 CpG methyltransferase인 SssI로 메틸화 시켰을 때 promoter 활성이 감소하였다. Pyrosequencing assay를 사용하여 TIM-3 유전자 DNA CpG 메틸화 정도를 측정하였을 때 TIM-3 유전자 …