Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"CpG DNA methylation"”.
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Effetto dell’etanolo sullo stato di metilazione del gene che codifica per la neurotrofina “Brain-Derived Neurotrophic Factor”
… because of its epigenetic regulation by methylation of BDNF promoters. The knowledge of the promoter that may be differentially regulated during various states of ethanol exposure and a detailed analysis of the effects of different ethanol exposure treatments on mRNA expression is …
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Methylation Change of Histone H3 and CpG Sites at the TIM-3 Gene Promoter in Response to Stimulation
… 사용하여 TIM-3 promoter에서의 epigenetic 변형을 분석하였다. 먼저 DNA methyltransferase inhibitor인 5-Azacytidine을 Jurkat T 세포에 처리하였을 때 TIM-3 발현이 증가하였다. 또한 TIM-3 promoter (-1500 ~ -1)에 CpG methyltransferase인 SssI로 메틸화 시켰을 때 promoter 활성이 감소하였다. Pyrosequencing assay를 사용하여 TIM-3 유전자 DNA CpG 메틸화 정도를 측정하였을 때 TIM-3 유전자 …