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Showing 1 to 11 of 11 for “"Coxsackievirus B3"”.
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Assay and Purification of Coxsackievirus B3
… for the purification for Coxsackie virus B3 (CB3), a Picornavirus provide the highest degree of purity with the greatest yield. The procedure. Quantitative methods for the assay and purification of CB3 were developed. CB3 was propagated in buffalo green monkey (BGM) cells in tissue …
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Host Factors That Influence Coxsackievirus B3 Replication and Pathogenensis
… mortality, and economic burdens yearly. Coxsackievirus (CV) is commonly isolated among enteric viruses and is an etiological agent of hand, foot, and mouth disease, hemorrhagic conjunctivitis, and myocarditis. The virus predominantly infects infants and young children and accounts for 11% …
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Adenosine triphosphate is an allosteric inhibitor of coxsackievirus B3 3Dpol
… the relative affinities of a stalled coxsackievirus elongation complex for non-cognate nucleotides uncovered a mixed inhibition profile of ATP. Among the six picornavirus species tested, this mode of inhibition seems specific to coxsackievirus B3 (CVB3). Engineered mutations in CVB3 …
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Pathological and genetic analysis of host susceptibility to cardiovirulent coxsackievirus B3 infection in mice
… American myocarditis cases are associated to coxsackievirus group B, type 3 (CVB3) infection. CVB3 infection of mice provides a useful model to study pathogenic mechanism of myocarditis. The objective of this study is to test the hypothesis that susceptibility, during the acute CVB3 infection, …
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Auftreten von Autoantikörpern gegen Flavoproteine mit covalent gebundenem Flavinadenindinukleotid bei Patienten mit idiopathischer dilatativer Kardiomyopathie und Myokarditis
… sowohl bei einer Myokarditis, die durch eine Coxsackievirus B3-Infektion bei Mäusen hervorgerufen worden ist, als auch in Sera von Patienten mit einer idiopathischen dilatativen Kardiomyopathie gezeigt werden. <br>Zwar konnten Anti-M7-Antikörper in einer Maus durch eine Coxsackievirus …
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The Tradeoffs for a Viral Mutant with Enhanced Replication Speed
… in cultured cells. By sequentially passaging coxsackievirus B3 in cultured cells and collecting the very earliest progeny, we selected for increased replication speed. We found that a single mutation in a viral capsid protein, VP1-F106L, was sufficient for the fast-replication phenotype. …
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Sensing of Picornavirus Infections
… that encephalomyocarditis virus (EMCV) and coxsackievirus B3 (CVB3), picornaviruses of the cardiovirus and the enterovirus genus respectively, are sensed by both MDA-5 and RIG-I. Sensing of these viruses in macrophages leads to the expression of type I IFN early after infection with IFNβ …
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Pharmacology of novel approaches designed to target picornaviral infections
… as identify new compounds from natural sources. Coxsackievirus A9 (CAV9) was used as a typical enterovirus and a plaque reduction assay was used to assess antivirus activity. Both approaches gave promising agents. Fluoxetine and dibucaine caused a complete CAV9 inhibition at low concentrations. …
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Examination of type I IFN mediated regulation of the post-transcriptional antiviral response
… including Vaccinia virus, Influenza virus and Coxsackievirus. Given these findings of rapid mRNA translation to enable a robust IFN antiviral response, and aware that this is an ATP consuming process, we next examined whether IFN-α/β treatment also exerted effects on cell metabolism. Through a …
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Factors That Influence Mammalian Enteric Virus Infection
… from three different genera: Enterovirus (PV and coxsackievirus B3 (CVB3)), Kobuvirus (Aichi virus) and Cardiovirus (Mengo virus). I determined that specific bacterial strains enhance thermal stability of subset of viruses, while others were stable in the absence of bacteria. Additionally, I …
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Verbesserung des CVB3-Maus-Myokarditismodells durch die Entwicklung pankreasattenuierter Coxsackieviren
Das Coxsackievirus B3 (CVB3)-Maus-Myokarditismodell wird standardmäßig zur Untersuchung der Virus-induzierten Myokarditis verwendet. Entgegen der CVB3-Infektion im Menschen stellt im murinen Organismus nicht das Herz, sondern das Pankreas das für die CVB3-Infektion suszeptibelste Organ dar. …