Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Cowpox Virus"”.
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A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)
Cowpox virus has been found to encode the inflammation modulatory protein (IMP) (Miller, C.G., 1997), a homologue vaccinia virus complement control protein (VCP). VCP belongs to regulation of complement activation (RCA) protein superfamily. It has been shown to inhibit both the alternative and …
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Molecular and evolutionary analysis of a gene conserved in most Orthopoxviruses
… is presented to show that variola and monkeypox viruses evolved independently from a common ancestor. An open reading frame (ORF), potentially coding for a protein of 341 amino acid residues, was found to be conserved in two strains of variola virus (Harvey and Somalia), but degenerate in the …
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Natural Killer Cell Recruitment and Activation Following Orthopoxviral Infection
<p>The orthopoxviridae are large, complex DNA viruses with important historical and clinical significance. Members of this genus encode numerous proteins known to subvert the immune response to infection, providing a useful system to probe required host responses for resistance and survival. …
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Structural Mechanism of Orthopoxvirus Sabotage of MHCI Antigen Presentation
… class I: MHCI) antigen presentation can help viruses to evade cytotoxic T-lymphocyte: CTL) detection and clearance. Cowpox virus, like other orthopoxvirus family members, is a large DNA virus, whose genomic termini encode numerous immunomodulatory genes, including two ER-resident MHCI …
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TRIM5α is a poxvirus restriction factor: viral evasion strategies and a pathway to antivirals
… TRIM5α as a restriction factor for vaccinia virus (VACV) and two VACV countermeasures. This study followed up a proteomic analysis showing that VACV infection of TERT-immortalised human foetal foreskin fibroblasts (HFFF-TERTs) induced TRIM5 downregulation. This observation was validated in …